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Target Concepts:
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Query: UMLS:C0030305 (
pancreatitis
)
16,014
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Studies have demonstrated that reactive oxygen species (ROS) are closely related to inflammatory disorders.
Nicotinamide adenine dinucleotide phosphate
oxidase (NOX), originally found in phagocytes, is the main source of ROS in nonphagocytic cells. Besides directly producing the detrimental highly reactive ROS to act on biomolecules (lipids, proteins, and nucleic acids), NOX can also activate multiple signal transduction pathways, which regulate cell growth, proliferation, differentiation and apoptosis by producing ROS. Recently, research on pancreatic NOX is no longer limited to inflammatory cells, but extends to the aspect of pancreatic acinar cells and pancreatic stellate cells, which are considered to be potentially associated with
pancreatitis
. In this review, we summarize the literature on NOX protein structure, activation, function and its role in the pathogenesis of
pancreatitis
.
...
PMID:Potential role of NADPH oxidase in pathogenesis of pancreatitis. 2513 19
Reactive oxygen species (ROS) regulates the activation of inflammatory cascades and tissue damage in acute pancreatitis. NADPH oxidase (NOX) is upregulated in
pancreatitis
and is one of the major enzymes involved in ROS production using NADPH as a general rate-limiting substrate. Dunnione, a well-known substrate of NAD(P)H:quinone oxidoreductase 1 (NQO1), reduces the ratio of cellular NADPH/
NADP
+
through the enzymatic action of NQO1. This study assessed whether a reduction in cellular NADPH/
NADP
+
ratio can be used to regulate caerulein-induced pancreatic damage associated with NOX-induced ROS production in animal models. Dunnione treatment significantly reduced the cellular NADPH/
NADP
+
ratio and NOX activity through the enzymatic action of NQO1 in the pancreas of the caerulein-injection group. Similar to these results, total ROS production and expressions of mRNA and protein for NOX subunits Nox1, p27
phox
, p47
phox
, and p67
phox
also decreased in the dunnione-treated group. In addition, caerulein-induced pancreatic inflammation and acinar cell injury were significantly reduced by dunnione treatment. This study is the first to demonstrate that modulation of the cellular NADPH:
NADP
+
ratio by enzymatic action of NQO1 protects acute pancreatitis through the regulation of NOX activity. Furthermore, these results suggest that modulation of the NADPH:
NADP
+
ratio in cells by NQO1 may be a novel therapeutic strategy for acute pancreatitis.
...
PMID:Pharmacological stimulation of NQO1 decreases NADPH levels and ameliorates acute pancreatitis in mice. 3058 37
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