Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 80-year-old patient in previously excellent state of health presented with septic syndrome for gangrenous cholecystitis and concomitant pancreatitis. Diagnostic paracentesis revealed microbiological evidence of Candida albicans in the abdominal cavity. Laparoscopic cholecystectomy was performed and examination of histological specimens confirmed peritonitis by fungal perforation of the gall bladder. In a complicated postoperative course the patient was finally cured choosing voriconazole (Vfend) for antimycotic therapy.
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PMID:Candida peritonitis in a patient with necrotising cholecystitis and pancreatitis. 1678 52

Azole antifungals are first-line options in the prophylaxis and treatment of invasive fungal infections. They are often used for prolonged (weeks to months) periods of time, particularly in patients with hematologic malignancies, or in those who have received a solid organ or hematopoietic stem cell transplant. Long-term use of azoles is associated with hepatotoxicity and hormone-related effects, including gynecomastia, alopecia, decreased libido, oligospermia, azoospermia, impotence, hypokalemia, hyponatremia, and (rarely) adrenal insufficiency. Voriconazole and posaconazole have been associated with peripheral neuropathies, and itraconazole and voriconazole with pancreatitis. In addition, voriconazole has been associated with periostitis, phototoxic reactions, and squamous cell carcinoma. Since many at-risk patients are commonly receiving multiple medications, it can be difficult for care providers to identify antifungal agent causality or contribution to patient symptoms. Knowledge and recognition of adverse events caused by azoles, leading to dose reduction or discontinuation, can generally reverse these adverse events.
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PMID:Adverse Effects Associated with Long-Term Administration of Azole Antifungal Agents. 3109 49