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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pancreatic transplantation is hampered by difficulties in controlling exocrine drainage. Methods of controlling exocrine drainage were assessed in 30 dogs receiving right lobe pancreatectomy. In the sham group, laparotomy and dissection of the pancreas were performed. In the others, the duct was either left open, ligated, anastomosed to jejunal mucosa, or injected with 1.5 mL of either silicone rubber, Neoprene, or Prolamine. Serial serum glucose and amylase levels were obtained at regular intervals and pancreatic biopsies were performed at two and eight weeks for examination. Glucose homeostasis was maintained throughout the study period. All animals developed severe pancreatitis as shown by hyperamylasemia by the second postoperative day, which resolved in most animals by the tenth to 14th day. Animals were free of ascites, pancreatic abscesses, and pseudocysts. All methods of ductal obstruction as well as the open duct drainage led to islet and acinar fragmentation and fibrosis. Endocrine function was preserved in all groups. In three animals with patent ductal-jejunal anastomoses, the pancreas appeared normal. Duct-to-jejunum anastomosis was the preferred method to preserve pancreatic function and morphology.
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PMID:Evaluation of techniques of controlling exocrine drainage after segmental pancreatectomy in dogs. Implications for pancreatic transplantation. 241 25

Pancreatic autotransplantation is a necessary requirement for studies on the technical aspects of pancreatic grafting. In the allograft model immunological problems influences the graft survival. In 25 mongrel dogs the left limb of the pancreas was transplanted into the grain with end to side vascular anastomosis. The body and right limb of the pancreas was removed and discarded. We have compared various technique for management the exocrine pancreas section (Neoprene-injected duct; open duct technique). Currently the rate of complications in segmental pancreas autotransplantation was high especially in Neoprene injected dogs. Reasons for this result from technical failures like venous thrombosis and pancreatitis. In every case it was possible to ameliorate the diabetes mellitus up to the 7th day. Histological we found dilated interlobe space up to 7 days after transplantation with open ducts and there were no signs of disturbance in the endocrine tissue. In the Neoprene-injected group we found a severe intraacinous oedema and 5 days after transplantation already a beginning fibrosis with destroyed islets of Langerhans.
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PMID:[Autologous heterotopic partial transplantation of the pancreas in the dogs with reference to different drainage methods]. 352 42

In 35 pancreatectomized dogs, the donor pancreatic tail was transplanted by end-to-side anastomoses between the portal vein and the celiac axis to the femoral vessels of the host. To influence the exocrine pancreas secretion of the graft we applied different methods of drainage of the pancreatic duct: open drainage to the abdominal cavity (Group I, n = 15), occlusion of the duct by Neoprene (Group II, n = 12) and by Ethibloc (Group III, n = 8). Main complications were rejection crisis and pancreatitis. Segmental pancreas allografts were rejected in group I within about 34 days, in group II within about 11 days, in group III within about 13 days. The fasting blood glucose levels in all 3 groups returned to normal 2 days after transplantation. Better results were achieved in the open-duct and Ethibloc-occluded grafts. 3 weeks after transplantation, a delayed and diminished increase of insulin concentration after glucose stimulation was observed compared to the dogs of the control group. Peak insulin values were significantly higher (p 0.01) in group I compared to group II. Histologically acinar atrophy with replacement by fibrous tissue occurred in all groups after 2 weeks. The least severe histological changes were observed in group II. The best results were achieved by the open-duct technique, whereas the occlusion groups showed a high rate of early complications like rejection, venous thrombosis and pancreatitis.
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PMID:[Allogeneic segmental heterotopic pancreas transplantation in the dog with reference to various drainage technics]. 392 96

Currently the rate of complications in segmental pancreas transplantation is very high. Reasons for this come from technical failures and from the site of immunology. To prove the cause of technical complications, several methods were used for the allogeneic segmental pancreas transplantation in diabetic dogs. To influence the exocrine pancreas secretion in grafts, we applied the intraductal injection of Ethibloc and Neoprene and the intraperitoneal drainage. By all these approaches it was possible to ameliorate an experimental diabetes in the recipients. Clearly better results were achieved in the Ethibloc-injected and open-duct grafts. The longest function time was about 6 months. Main complications, especially in the Neoprene-injected group, were venous thrombosis, pancreatitis and graft rejection.
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PMID:Allogeneic segmental pancreas transplantation in diabetic dogs with and without occlusion of the pancreatic duct. 634 15