Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the early stages of experiments there was a structural-metabolic reconstruction in the adrenal cortex, manifest by changes in interzonal relations and dissociation of the activity of enzymes responsible for energy supply and synthesis of steroid hormones. Analogous changes were also seen later on. However, in the early stages that process was a response to the pancreas injury, whereas in the later period it preceded the emergence of repeated lesions in the gland. In animals with experimental pancreatitis, administration of metapyrone caused an activation of NAD-diaphorase in the glomerular and reticular zones and concurrent potentiation of the activity of glucose-6-phosphate dehydrogenase in all 3 zones of the adrenal cortex.
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PMID:[Histoenzymological characteristics of the adrenal cortical reaction in variants of experimental pancreatitis]. 695 49

A disturbed energy metabolism in pancreatic acinar cells is discussed as factor contributing to the development of acute pancreatitis (AP). In this study, we investigated to what extent the mitochondrial ATP producing capacity is impaired in the pancreatic tissue of rats with experimental AP. For preparation of mitochondria from rat pancreas, routine isolation procedures (tissue homogenization and differential centrifugation) were applied. Mitochondria were isolated from rats with edematous pancreatitis produced by hyperstimulation with caerulein, and from rats with mild necrotizing acute pancreatitis. The latter form of AP was induced by a temporary occlusion of the biliary pancreatic duct accompanied by a simultaneous intravenous injection of caerulein plus secretin and an intraabdominal administration of ethanol. As functional parameters of oxidative phosphorylation, the respiration rate, the mitochondrial membrane potential, and the activity of the complex I of the respiratory chain were determined. Mitochondria from rats with caerulein AP showed an enhanced respiration (61% vs. saline control) and a diminished membrane potential (-17 mV) if respiring with succinate in the non-phosphorylating state. This indicates an increased proton leak across the mitochondrial inner membrane. In the mild necrotizing AP, mitochondria were characterized by a decreased respiration with NAD(+)-linked substrates (-33% vs. sham-operated animals). This inhibition of respiration was confirmed by the reduced activity measured for the NADH-cytochrome c reductase (-32%). In both models of experimental AP the potency of mitochondria to produce ATP was significantly diminished. The stronger impairment of mitochondrial functions were found in the necrotizing form of AP. Reactive oxygen species may lead to the observed alterations--to the enhanced permeability of the mitochondrial inner membrane as well as to the inhibition of the complex I of the respiratory chain.
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PMID:[Modification of energy supply by pancreatic mitochondria in acute experimental pancreatitis]. 922 43