Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This case study reports moderate elevation of serum triglycerides in a woman with a Type III pattern of hyperlipoproteinemia, when taking a normal diet but drinking alcohol heavily, who developed eruptive xanthomata with a grossly raised triglyceride concentration and chylomicronemia when pregnant and also when taking a combined oral contraceptive pill (OC) containing 50 mcg of estrogen. In December 1973 the patient, then taking Norinyl 1, was switched to Eugynon 30 (30 mcg of ethinyl estradiol and .25 mg of levonorgestrel), and clofibrate (2 gm/day) was prescribed along with a low carbohydrate and fat content diet. By February 1974 the patient had lost weight, the skin lesions had cleared, serum lipid concentrations had fallen, and the electrophoretic beta-band pattern was normal. The patient became pregnant in October 1974, and by the second trimester of pregnancy xanthomata had recurred, but erratic treatment with clofibrate and diet regulation eventually lowered triglyceride levels and she delivered a 2.61-kg baby at 39 weeks. Persistent chylomicronemia is a serious complication of pregnancy because of the risk of pancreatitis and the potential risk of fetal malnutrition. Similarly, high estrogen-containing OCs are contraindicated in patients with Type III or other hypertriglycidemic states.
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PMID:The effect of pregnancy and two different contraceptive pills on serum lipids and lipoproteins in a woman with a type III hyperlipoproteinaemia pattern. 62 21