Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In view of a possible role of genetic factors in the etiology of chronic calcific pancreatitis, we undertook a study of the frequency of HLA antigens in this disease. Sixty-four patients with chronic calcific pancreatitis were typed for the HLA-A, -B and -C loci. Fourteen of these 64 patients (21.9%) were found to have antigen B13 compared to 7.5% of 425 controls. These results have a P value of 0.00059 which remains significant (P = 0.020) even when multiplied by the total number of antigens tested. Sex, alcoholism, age at the clinical onset of the disease, presence of pain, and diabetes had no apparent influence on the distribution of HLA alleles. The significant association between chronic calcific pancreatitis and HLA antigen B13 further supports the role of genetic factors in the etiology of the disease.
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PMID:HLA-B13 and chronic calcific pancreatitis. 695 94

HLA A, B and C antigens were determined in 128 patients with chronic pancreatitis in Japan. Patients were divided into two groups, chronic alcoholic and chronic idiopathic, from two parts of Japan, the eastern and the western part, with control subjects in each region. A significantly higher frequency of B5 was demonstrated among chronic idiopathic pancreatitis and of B13 among chronic alcoholic pancreatitis in the eastern part, and no definite findings were obtained in the western part of Japan. On the other hand, the frequency of BW 54 was lower among chronic alcoholic pancreatitis in both parts of Japan, but the corrected p value for this antigen was not statistically significant. These facts suggest that 'HLA antigens in chronic pancreatitis have some racial and regional differences.
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PMID:HLA antigen and chronic pancreatitis in Japan. 727 3