Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experimental cholelithiasis was established by feeding hamsters with lithogenic diet. Morphological changes of extrahepatic bile ductal epithelia were observed under light and electron microscopes at weeks 1, 2, 4 and 6 after the treatment. Moreover, the changes of mucus composition in goblet cells, which were located among the epithelia, were particularly evaluated using High iron diamin-Alcian blue pH 2.5 (HID-AB) stain. Compared with the controls, goblet cells of both superior bile duct (S-BD) and inferior bile duct (I-BD) increased in number, but more prominently in I-BD than in S-BD. Furthermore, goblet cells of the controls mainly contained sulfomucin positive for the HID in their cytoplasm. On the other hand, goblet cells of the lithogenic diet group mainly contained sialomucin negative for the HID in their cytoplasm. Electron microscopy demonstrated the extensive accumulation of secretory granules in the cytoplasm of the epithelial cells of both S-BD and I-BD. These results suggest that cholelithiasis may enhance the mucus secretion from extrahepatic bile ductal epithelia, and that the mucus oversecretion results in the protective effect on biliary epithelia. On the other hand, it is suggested that the mucus oversecretion may cause the bile retention in extrahepatic bile ducts, and also may have relation to the choledochitis or pancreatitis associated with cholelithiasis.
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PMID:[Morphological changes of extrahepatic bile ductal epithelia in hamsters feeded with lithogenic diet]. 140 69

Hyper IgG4 syndrome (HIDI is a multisystem disease characterized by high levels of immunoglobulin IgG4 with possible involvement of the pancreas, lung and lymph nodes as well as other organs. It was first described in connection to autoimmune pancreatitis but since then, it became clear that it can also affect many other organs. The disease involves the thorax and lesions were described in the mediastinum, airways, lung parenchyma and pleura. it can simultaneously involve multiple organs or be localized in just one. HID can develop in part of the fibro-inflammatory diseases of the chest without clear etiology like pseudo tumors, mediastinal and pleural fibrosis or inflammation. HID was also found in connection with various diseases in the airways. The HID lesion is typically rich in plasma cells positive to IgG4, fibrosis and vascutitis. This disease is rare and until now there were almost no cases reported in Israel. High clinical suspicion can make the diagnosis and prescribe the right therapy. The prognosis is favorable if the diagnosis is made on time. New studies are needed to understand the connection and the importance of this pathology to the lungs and also the most suitable treatments available for it.
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PMID:[Pulmonary hyper IgG4 disease]. 2551 77