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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present case report of primary hyperparathyroidism treated surgically as well as a review of literature concerning this subject. The disease of not well known etiology presents with elevated parathormon levels and hypercalcemia. Primary hyperparathyroidism which states 85% percent of all kinds of hyperparathyroidism is usually parathyroid adenoma, in 11-15% glandular hyperplasia and in 1-4% parathyroid cancer. Clinical symptoms are muscle weakness and fatigue, nephrolithiasis, occasionally peptic ulcers, pancreatitis, hypertension. Laboratory test reveal increased level of PTH, hypercalcemia, elevated alkaline phosphatase levels and decreased phosphorus levels. Diagnostic imaging techniques such as ultrasonography, MRI or CT have sensitivity about 52-75%. Highest sensitivity in localization of ectopic parathyroid adenoma has sestamibi scintigraphy with technetium-99. Skeleton x-rays show typical changes in distal parts of bones and osteopenia. Treatment of choice is surgical excision of adenoma. Normalization of PTH and calcium levels after surgery and improvement of renal, musculoskeletal and circulatory system function could be achieved in 95%. Most common complications are recurrent laryngeal nerve injury, hypo- or hyperparathyroidism, bleeding or stridor.
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PMID:[Primary hyperparathyroidism--case report and review of the literature]. 1682 51

Parathyroid carcinoma is a rare disease and accounts for less than 1% of all cases of primary hyperparathyroidism. Many times, parathyroid carcinoma is detected only after surgery. Parathyroid carcinoma as a cause of acute pancreatitis is uncommon. We report this case of acute severe pancreatitis associated with parathyroid carcinoma. Hypercalcemia was found during workup for acute pancreatitis which was due to primary hyperparathyroidism. During surgery, there was a suspicion of parathyroid carcinoma and en bloc resection was done followed by adjuvant radiation therapy. It is important to treat the precipitating factor for acute pancreatitis. Surgery is the mainstay of treatment for parathyroid carcinoma.
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PMID:Parathyroid Cancer Causing Acute Severe Pancreatitis. 3155 81