Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Alcohol consumption is the most important etiological factor of chronic pancreatitis (around 70%). Smoking, ethnic-racial predispositions, diets high and low in fat and high in protein may also contribute to the development of chronic pancreatitis. Non-alcoholic chronic pancreatitis of unknown cause makes up 10% to 30% of patients with chronic pancreatitis. Two subgroups have been reported: juvenile (about 25 years) and senile (up 65 years). Tropical pancreatitis has been observed in children and young men in many African and Asian countries. This disease develops because of fat and protein deficiency or nutritional deficiency in general, also due to cyanogenes present in cassava. Hereditary chronic pancreatitis is a rare disease connected with autosomal transmissions. Dr Whitcomb reported, that hereditary chronic pancreatitis developed because of trypsines mutation. Mutant "hypertrypsin" is not inactivated by enzymes; this way it leads to pancreas autodigestion. Obstructive chronic pancreatitis is caused by longterm pancreatic ducts obstruction. In many rare causes leading to chronic pancreatitis among other are: hypercalcaemia, hyperlipoproteinemia, some drugs and pancreatitis associated with autoimmune disorders. Newest information about etiology and pathogenesis of chronic pancreatitis is yielded by recent immunohistochemical research. This research shows increasing irregular improper antigens expression of class I and/or class II MHC in pancreas as well as the role of Transforming Growth Factor Alpha in chronic pancreatitis development. This illness is still a puzzling problem.
 ...
PMID:[Contemporary opinions on the etiology of chronic pancreatitis]. 1050 45

Chronic pancreatitis is in advanced European and North American countries the statistically most important source of morbidity and mortality among benign pancreatopathies. It is defined as affection of the pancreas by chronic inflammation whereby the secretory parenchyma is gradually replaced by fibrous tissue. The fibrosis is irreversible and the disease has a progressing trend. In advanced countries the main pathogenetic factor has been for some centuries alcohol consumption. Chronic pancreatitis can be classified with regard to its morphology, etiology or pathogenesis. Most frequently the classification of chronic pancreatitis with regard to morphological changes is used, whereby the latter are based on different pathogenetic mechanisms. The present Marseille-Rome classification is valid from 1988 and divides chronic pancreatitis according to morphological changes into three groups. 1. Chronic calcifying pancreatitis. 2. Obstructive chronic pancreatitis. 3. Primarily inflammatory chronic pancreatitis. In some publications pancreatic fibrosis is listed as a special category. The submitted paper gives an up to date picture of chronic pancreatitis from the aspect of etiopathogenesis, it draws attention to the weak points of the contemporary classification and provides information on the genetic diagnosis of some rare forms of this highly prevalent disease.
 ...
PMID:[Etiopathogenesis of chronic pancreatitis--present state]. 1673 25