Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Examinations of 55 major duodenal papillas (MDP) amputated in patients with chronic relapsing pancreatitis revealed papillomatosis of the opening zone in 20 (36%). Papillomatosis developed when the pancreating and bile ducts discharged into the duodenum separately at the top of MDP without forming an ampoule. Papillomatosis was manifested by fibrous-epithelial papillar hyperplastic outgrowths representing pathologically altered folds of the MDP mucous membrane. The features of changes in papillary outgrowths were shown to include circulatory disorders, lympho-plasmocytic infiltration of the stroma, adenomatosis, etc. The causes of papillomatosis development and its association with chronic relapsing pancreatitis are discussed.
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PMID:[Papillomatosis of the opening of the major duodenal papilla in chronic, recurrent pancreatitis (based on surgical biopsy data)]. 44 85

Morphological studies of 15 polyps of the major duodenal papilla (MDP), 50 amputated MDPs and 5 ectomized MDPs from patients with chronic relapsing pancreatitis were carried out. Three groups of changes were detected: (1) variants of the structure: separate confluence of the common bile and major pancreatic ducts into the duodenum, additional pancreatic ducts, dystopia of the pancreatic gland tissue; (2) hyperplastic changes: papillomatosis of the MDP opening, intrapapillar adenomatous polyps, adenomyosis of MDP wall; (3) tumors: adenoma and carcinomas. No relationship between hyperplasias and calculi and inflammation of bile ducts was confirmed. Some kinds of MDP pathology were found to depend on variants of its structure. Papillomatosis of MDP was shown to be capable of malignancy.
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PMID:[Structural variants, hyperplastic changes and tumors of the major duodenal papilla (based on surgical material from patients with chronic recurrent pancreatitis)]. 727 4