Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Systemic lupus can involve any part of the gastrointestinal (GI) tract. Diarrhea generally results from complications arising from infection, drugs or pancreatitis. We herein report the case of a 40-year-old hypertensive man with a psychotic disorder in whom the evaluation of chronic diarrhea revealed a diagnosis of systemic lupus erythematosus (SLE), diffuse proliferative glomerulonephritis and protein-losing enteropathy that required treatment with both steroids and mycophenolate mofetil. Over the following year, the patient developed atrial fibrillation, miliary tuberculosis and generalized clonic tonic seizures. He is currently under regular follow-up care and receives antiepileptics, antihypertensives, diltiazem, amiodarone and warfarin.
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PMID:Chronic diarrhea as the presenting complaint of systemic lupus erythematosus in a man. 2315 18

Central pontine myelinolysis is a demyelinating condition affecting the pons characterized by an acute progressive quadriplegia, dysarthria, dysphagia, and alterations of consciousness. Pathologic features include prominent demyelination in the central pons with sparing of axons and neurons. This condition is usually associated with systemic disorders such as hyponatremia, chronic alcoholism, liver failure, severe burns, malignant neoplasms, hemorrhagic pancreatitis, hemodialysis, and sepsis. There are limited reports of psychosis in patients with central pontine/extrapontine myelinolysis (CPEM). We have described a case of CPEM with psychosis as a complication which recovered completely with treatment given for short duration using low dose atypical antipsychotic (quetiapine). We also discuss etiopathology and clinical outcome of psychosis in this rare neurological disorder.
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PMID:Acute psychosis with a favorable outcome as a complication of central pontine/extrapontine myelinolysis in a middle aged man. 2337 30

Olanzapine is an atypical antipsychotic agent that was approved by the Food and Drug Administration in 1996 for treatment of psychotic disorders, bipolar disorder, and schizophrenia. Since that time, numerous case reports have been published that describe the association of olanzapine and the development of pancreatitis. Furthermore, 3 reports suggest the mechanism of olanzapine-induced hypertriglyceridemia as the etiology of this progression. We report a case of a 36-year-old man who developed necrotizing pancreatitis secondary to olanzapine-induced hypertriglyceridemia. This case, to our knowledge, is the most severe case of this progression and the first case requiring plasmapheresis for acute management.
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PMID:Olanzapine-Induced Hypertriglyceridemia Resulting in Necrotizing Pancreatitis. 2780 66


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