Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sixteen patients were treated for gastrocolic fistula arising as a complication of peptic ulcer (11 cases), colonic perforation (2), gastric cancer (1), colonic cancer (1) or pancreatitis (1). The predominant symptoms were diarrhoea, weight loss and abdominal pain. Barium meal and barium enema were the most reliable means of diagnosis, and no fistula was gastroscopically demonstrable. A one-stage en bloc resection of the involved gastrocolic region was performed in eight cases. Other operations were simple excision (3), gastric resection with closure of the colonic wall (2) and colectomy with closure of the gastric wall (2). In one case cure was achieved with cimetidine, without surgical intervention. Four patients died postoperatively and two had recurrence of fistula.
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PMID:Gastrocolic fistulas. 337 89

We prepared monoclonal antibodies against pancreatic cancer associated antigen (PCAA) from normal colonic mucosa (PCAAc) and prepared an assay system to detect the circulating PCAAc in sera. 200 patients with cancer including 85 pancreatic cancer and benign disease were compared with 40 normal healthy individuals. Diagnostic rate of pancreatic cancer was 64/85 (75%) but other malignancy also showed elevated PCAAc: 18/19 (94.7%) of hepatoma and 19/37 (51.4%) of gastric cancer. In pancreatitis, 8/17 (47.1%) showed elevated PCAAc. Compared with our previous reports of PCAA assay, these results indicated that diagnostic sensitivity of pancreatic cancer was increased but specificity of it was decreased.
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PMID:Pancreas cancer associated antigen from normal colonic mucosa (PCAAc) assayed with monoclonal antibody. 377 Aug 9

The precision of CA 19-9 RIA kit was evaluated by recovery, reproducibility and dilution test with very satisfactory results. The CA 19-9 value in sera from 52 healthy individuals and from 224 patients with gastric intestinal cancer and other benign disease, showed an increased positive rate in several cases of gastric intestinal cancer. For example, the positive rate in pancreatic cancer, bile duct cancer, colo-rectal cancer, gastric cancer, esophagus cancer, primary biliary cirrhosis diabetes mellitus, liver cirrhosis and chronic hepatitis was 60%, 75%, 55.6%, 45.6%, 20%, 28.6%, 22.7%, 13.7% and 1.7% respectively. By contrast, values from patients with acute hepatitis, fulminant hepatitis, fatty liver, gastric duodenal ulcer, pancreatitis, and primary liver cancer were within the normal range. In this study, CA 19-9 RIA were found to be significant as an adjunct in the management of patients with gastrointestinal cancer, especially pancreatic cancer, and bile duct cancer.
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PMID:[Serum determination of CA 19-9 in patients with digestive cancers and its diagnostic evaluation]. 658 10

Intraoperative electron beam radiotherapy (IORT) is clinically used as a potential adjunctive treatment to surgery of locally advanced pancreatic and gastric cancer. The tolerance of the pancreas to IORT was studied in 15 adult beagles, divided in 3 groups of 5 beagles in which 25, 30 or 35 Gy IORT was delivered through a 6-7 cm circular lucite cone with 6-8 MeV electrons to the pancreas and medial wall of the duodenum. The dogs were followed for endocrine and exocrine pancreatic insufficiency. Two dogs (13%) developed radiation-induced morbidity which consisted of a common bile duct stenosis and an enterocolic fistula, as was confirmed at autopsy after 8 and 18 months, respectively. After a follow-up of 1 year, none of the dogs had developed pancreatitis, diabetes or exocrine insufficiency. There was a significant reduction in serum insulin levels and glucose clearance rates without overt diabetes for 30 Gy and 35 Gy (p < 0.05). No significant changes were found for 25 Gy. This study suggests that 25 Gy IORT to the pancreas may be used clinically, and that higher IORT doses may induce endocrine pancreatic insufficiency in the long-term.
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PMID:Intraoperative irradiation of the canine pancreas: short-term effects. 812 87

Efficacy of postoperative pancreatitis prevention is assessed in 123 patients with gastric cancer. Pancreatic bloodflow and central hemodynamics were assessed by rheography, activities of serum amylase and free-radical oxidation by biochemiluminescence of blood plasma. After radical surgery on the stomach, disorders of hemocirculation develop in the pancreas, leading to ischemia of the organ and formation of venous congestion; free-radical oxidation is activated and fermenturia increases. Prolonged epidural blocking with lidocaine prevented a decrease of arterial inflow to the pancreas, decreased the intensity of free-radical oxidation, and was more effective than isoptin therapy.
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PMID:[The evaluation of the efficacy of preventing postoperative pancreatitis in stomach cancer patients by using izoptin and a prolonged peridural lidocaine block]. 977 Aug 22

Misoprostol, a prostaglandin E1 analog, is a racemate of four stereoisomers. On administration it rapidly de-esterifies to its active form, misoprostolic acid. Misoprostolic acid is 85% albumin bound and has a half-life of approximately 30 minutes. It is excreted in urine as inactive metabolites. No significant drug interactions have been reported. Besides its gastrointestinal protective and uterotonic activities, misoprostol regulates various immunologic cascades. It inhibits platelet-activating factor and leukocyte adherence, and modulates adhesion molecule expression. It protects against gut irradiation injury, experimental gastric cancer, enteropathy, and constipation. It improves nutrient absorption in cystic fibrosis. Misoprostol has utility in acetaminophen and ethanol hepatotoxicity, hepatitis, and fibrosis. It is effective in asthmatics and aspirin-sensitive asthmatic and allergic patients. It lowers cholesterol and severity of peripheral vascular diseases, prolongs survival of cardiac and kidney transplantation, synergizes cyclosporine, and protects against cyclosporine-induced renal damage. It works against drug-induced renal damage, interstitial cystitis, lupus nephritis, and hepatorenal syndrome. It is useful in periodontal disease and dental repair. Misoprostol enhances glycosoaminoglycan synthesis in cartilage after injury. It prevents ultraviolet-induced cataracts and reduces intraocular pressure in glaucoma and ocular hypertension. It synergizes antiinflammatory and analgesic effects of diclofenac or colchicine and has been administered to treat trigeminal neuralgic pain. It reduces chemotherapy-induced hair loss and recovery time from burn injury, and is effective in treating sepsis, multiple sclerosis, and pancreatitis.
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PMID:Misoprostol therapeutics revisited. 1119 38

The results of clinical application of an original method of operable gastric cancer treatment including pre- and intraoperative irradiation (IORT) and radical intervention are presented. According to a randomized study, combination treatment did not involve intra- and postoperative complication rates higher than those of surgery alone. Moreover, a significant decrease in postoperative pancreatitis was registered. IORT is a highly effective method of adjuvant treatment of operable gastric cancer. Due to its application in conjunction with preoperative irradiation and radical surgery, the end results of locally-advanced gastric cancer improved.
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PMID:[Results of clinical studies of the efficacy of intraoperative radiotherapy in combined treatment of stomach cancer]. 1178 11

Helical computed tomography (CT) is useful in identifying postoperative anatomic changes, complications, and tumor recurrence in gastric cancer patients who have undergone gastrectomy. Postoperative anatomic changes can usually be identified on consecutive CT scans. Complications include anastomotic leakage, duodenal stump leakage, intraabdominal bleeding, wound complications, and other less common complications (postoperative pancreatitis, retention of surgical foreign bodies, diffuse peritonitis). The degree and extent of bowel wall thickening is important in diagnosing tumor recurrence; however, CT lacks specificity. Large or conglomerated lymph node metastases can be easily diagnosed at CT; however, small solitary or focal metastases may not be detected or differentiated from nonmetastatic nodes. Ascites, a common finding with peritoneal seeding in gastrointestinal tumors, is well depicted at CT. Hematogenous metastases from gastric carcinoma are most frequently seen in the liver and are best demonstrated with helical CT performed during the portal venous phase of enhancement (sensitivity >90% for the detection of lesions >1 cm). The sophisticated surgical procedures used in gastrectomy can alter normal anatomy and make image interpretation difficult; thus, familiarity with the appearance of postoperative anatomic changes, complications, and tumor recurrence is essential for accurate CT evaluation of affected patients.
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PMID:Postoperative anatomic and pathologic findings at CT following gastrectomy. 1189 22

Total gastrectomy with pancreaticosplenectomy for gastric cancer has been proposed for facilitating lymph node dissection or for resection of direct tumor invasion to the pancreas, especially for T4 lesions. Its effectiveness in improving patient survival is still controversial, and higher morbidity and mortality with this procedure have been reported in several series. Such risks to patient survival were not observed in the Japanese series. Based on a prospective gastric cancer database maintained from 1987 to 1999 in our institution, the morbidity and mortality were analyzed in our series of pancreaticosplenectomies. A total of 1,278 patients with gastric cancer received gastrectomy in our surgical unit. Of these, 127 patients underwent curative total gastrectomy with pancreaticosplenectomy in order to facilitate lymph node dissection or removal of direct tumor invasion. Operative time, postoperative hospital stay, postoperative complications, and surgical mortality were analyzed. Compared to another 201 total gastrectomies, longer mean operative time (7.91 +/- 2.16 hours vs. 6.67 +/- 2.01, p <0.001) and postoperative hospital stay (median, 24.5 days vs. 17, p <0.001) for combined organ resection (pancreaticosplenectomy) were shown in this series. The major complication rate, including intraabdominal abscess, anastomotic leak, postoperative bleeding, pancreatitis/fistula, chylous leak, and general complications causing unstable vital signs (26.8% vs. 11.9%, p = 0.001), but not the mortality rate (6.3% vs. 4.8%, p = 0.608), was also shown to be higher in pancreaticosplenectomy patients. The most frequent fatal complication was intraabdominal abscess. However, more than 50% of complications occurred in the first 40 pancreaticosplenectomies (1987-1991); after adequate accumulation of experience, the total complication rate (57.5% vs. 35.6%, p = 0.021), major complication rate (40% vs. 20.7%, p = 0.022), and mortality rate (17.5% vs. 1.1%, p = 0.001) improved significantly in the remaining 87 patients (1991-1999). We therefore conclude that total gastrectomy with pancreaticosplenectomy can be performed by experienced surgeons with acceptable risk of morbidity and mortality.
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PMID:Higher morbidity and mortality after combined total gastrectomy and pancreaticosplenectomy for gastric cancer. 1205 18

The stress injury of the gut organs due to ischemia constitutes the cause of complications and mortality after performance of radical operation for gastric cancer. Alcoholization of celiac nerves is proposed for an ischemic damage prophylaxis. Complications and mortality were analyzed in two groups of patients operated on, using endotracheal narcosis plus alcoholization and without it. Trustworthy lowering of the complications and mortality occurrence frequency, in 1.5-2 times accordingly, mainly owing to ischemic disorders (pancreatitis, the hole organs wall necrosis), were noted in conduction of alcoholization. The differencies observed were pronounced the most after performance of highly traumatic combined interventions.
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PMID:[Prophylaxis of microcirculation disorders caused by operative trauma and accompanying complications of radical surgery for gastric cancer]. 1237 35


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