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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Six patients receiving total parenteral nutrition (TPN) developed hypercalcemia and acute pancreatitis. Four were long-term home TPN patients, and two were short-term hospital TPN patients. Causes of pancreatitis other than hypercalcemia were not found. The etiology of the hypercalcemia remained unclear and in particular was not due to calcium infusion or hyperparathyroidism. In 4 patients in whom it was measured, the plasma parathyroid hormone was normal (in 2) or nondetectable (in 2). Hypercalcemia and pancreatitis subsided with discontinuation of TPN. Thus, some patients receiving TPN develop hypercalcemia, and in some of these pancreatitis ensues.
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PMID:Pancreatitis in association with hypercalcemia in patients receiving total parenteral nutrition. 677 4

Although further work is needed for understanding the mechanism of the action of alcohol on the pancreas, it can be admitted that in man, the rat and the dog, chronic alcohol consumption leads to precipitation of proteins in the juice and the ducts. When these precipitates are observed, an alteration of the protein to bicarbonate ratio is always found, as a result of an increase in protein concentration or a decrease in bicarbonate concentration, or both, It is reasonable to assume that an increased cholinergic tone is responsible for the increased secretion of protein. The decrease in bicarbonate secretion is not explained. It is worthwhile mentioning that, in hypercalcaemic dogs, protein precipitates are found in the juice associated with an increased concentration of protein and a decreased concentration of bicarbonate. It is known that hypercalcaemia (hyperparathyroidism) is a cause of chronic calcifying pancreatitis (noel-Jorand et al, 1981b).
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PMID:Alcoholic pancreatitis. 701 50

Two series of patients treated for primary hyperparathyroidism are reviewed for the incidence of associated pancreatitis. In an earlier series of 150 hyperparathyroid patients, six had documented pancreatitis as one of the primary clinical manifestations. Review of a more recent series failed to uncover a single case of pancreatitis in 26 patients with primary hyperparathyroidism. The incidence of pancreatitis associated with hyperparathyroidism appears to be steadily decreasing, possibly reflecting the earlier diagnosis of parathyroid disease, which is due to widespread screening testing methods currently available.
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PMID:Pancreatitis associated with primary hyperparathyroidism. 711 3

Pancreatic ascites is usually considered to be a sequela of chronic alcoholic pancreatitis. Our patient had pancreatic pseudocyst formation and pancreatic ascites after acute pancreatitis, the latter secondary to hypercalcemic pancreatitis and documented hyperparathyroidism.
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PMID:Pancreatic ascites: an unusual complication of hyperparathyroidism. 722 72

Of 1,153 patients with surgically confirmed primary hyperparathyroidism operated on at the Mayo Clinic between 1950 and 1975, only 17 (1.5%) had coexisting or prior pancreatitis. This frequency of association approximates the reported incidence of pancreatitis among general hospital patient populations. Other factors of possible etiologic significance in pancreatitis, such as gallstones or alcohol abuse, were present in 11 of the 17 patients. Cure of the hyperparathyroidism was usually not associated with amelioration of symptoms due to pancreatitis. A review of the available data, including experimental evidence, does not support a cause-and-effect relationship between primary hyperparathyroidism or hypercalcemia and pancreatitis.
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PMID:Hyperparathyroidism and pancreatitis. Chance or a causal association? 735 Mar 71

Acute pancreatitis as a manifestation of hyperparathyroidism (HPT) has been reported in the literature but the concept of causal relationship has been disputed. We report a case of acute pancreatitis where the presence of hypercalcemia led to the diagnosis of primary HPT. No other current risk factors for pancreatitis were identified and no symptoms of HPT were present prior to this episode. We review the literature regarding the role of HPT in the pathogenesis of acute pancreatitis.
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PMID:Acute pancreatitis as the first manifestation of hyperparathyroidism in an otherwise asymptomatic patient. 749 84

The relation between hypercalcemia and pancreatitis, first described in patients with hyperparathyroidism, is controversial. Other causes of hypercalcemia also have been associated with pancreatitis. In this report, the authors describe a patient with pancreatitis and the milk-alkali syndrome who had the classic triad of hypercalcemia, alkalosis, and renal insufficiency. The authors also review the literature for all the reported cases of pancreatitis associated with hypercalcemia.
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PMID:Case report: milk-alkali syndrome and pancreatitis. 807 35

We report a case of chronic calcifying pancreatitis and exocrine pancreatic deficiency in a patient with chronic renal failure under hemodialysis. We analyze the possible relationship between these two entities with special reference to the role of secondary hyperparathyroidism and extraosseous or metastatic calcification.
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PMID:[Chronic calcifying pancreatitis and chronic renal failure]. 818 17

Pancreatitis occurred in 13 (5.6%) of 234 patients (76 men, 158 women; mean age 63 [2-83] years) who were operated on for primary hyperparathyroidism (pHPT) between 1987 and 1992. The pancreatitis patients had a significantly higher median level of parathormone (340 pg/ml), of serum calcium (3.2 mmol/l) and of thyroid weight (1.7 g) than the remaining 221 patients (135 pg/ml; 2.9 mmol/l; 1.0 g, respectively: P < 0.05 for each). In ten patients pHPT had been diagnosed during an attack of pancreatitis: pancreatitis had been the diagnostic clue to pHPT. After conservative treatment of the pancreatitis and parathyroidectomy seven of the ten patients were free of symptoms during the follow-up. In one patient pancreatitis recurred postoperatively and two patients died of the consequences of haemorrhagic necrotizing pancreatitis. Cholelithiasis, as another possible causative factor for pancreatitis, was present in five of the 13 patients (38%). None of the patients was an alcoholic. These data indicate that there is a positive correlation between advanced pHPT and pancreatitis. Pancreatitis may be the expression of much advanced hyperparathyroidism which has been diagnosed too late.
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PMID:[Pancreatitis in primary hyperparathyroidism (pHPT) is a complication of advanced pHPT]. 819 41

Hyperparathyroidism is a rare cause of pancreatic inflammatory disease. Appropriate treatment of coexistent hyperparathyroidism and pancreatitis, especially when complicated by pseudocyst formation, is unsettled. We describe two patients with primary hyperparathyroidism who developed pancreatitis associated with multiple pseudocysts. The largest cyst in each patient was 9 and 5 cm, respectively. After correction of hyperparathyroidism and normalization of serum calcium levels by removal of a parathyroid adenoma, the pseudocysts resolved in both patients, as documented with computed tomography. We conclude that uncomplicated pancreatic pseudocysts in patients with primary hyperparathyroidism can be treated expectantly. Surgical correction of hyperparathyroidism and normalization of serum calcium levels should precede pancreatic intervention when possible, since pseudocyst resolution is likely and the risks of postoperative hypercalcemia are avoided.
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PMID:Pancreatic pseudocyst resolution after parathyroidectomy for hyperparathyroidism. 820 42


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