Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Duodenal stenosis in chronic relapsing pancreatitis occurs in 20% of our patients. In 21 of our cases, the stenosis was always in the descending portion of the duodenum, and in two-thirds it caused an obstruction. The stenosis is always concentric with destruction of the mucosal pattern, widening of the neighbouring folds, irregular contours, and, possibly, straightening of the medial margin of the duodenum. There may be widening of the duodenal loop and frequently the duodenal loop is dilated. The causes for these appearances vary, but a peri-pancreatitis or duodenitis are most frequent. There is no close relationship with the severity of the pancreatitis. Our findings are compared with the small number of reports to be found in the literature.
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PMID:[Duodenal stenosis in chronic relapsing pancreatitis (author's transl)]. 14 44

The authors examined 18 rats--6 controls and 12 experimental. After duodenostomy by means of a puncure of the duodenal wall duodenal content from healthy persons was administered in the duodenum of control rats. In the experimental group of animals duodenal content form patients with pancreatitis was administered. Duodenum, pancrea, liver and kidneys were examined histomorphologicaly. The obtained results showed that there were no substantial deviations from the norm in the histomorphological picture of the examined organs after administration of duodenal content. In the organs of the experimental group these changes could be characterized as acute necrotic pancreatitis, acute duodenitis, acute finely dotted dystrophy of liver and slightly, manifested acute renal insufficiency. the authors suggested the occurrence of some toxic substances in the duodenal content in patients with acute pancreatitis.
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PMID:[Effect of duodenal contents of patients with pancreatitis following its introduction into the duodenum of healthy rats]. 103 37

The clinical and pathological characteristics of Curling ulcer were defined by early and serial endoscopic examination of the duodenum in 37 burned patients. Duodenal disease was present in 27 patients and occurred only in patients with burns involving more than 38 percent of the total body surface. Erosive "duodenitis" could occur within 12 hours after injury and was usually associated with acute gastric disease. Isolated duodenitis occurred only in patients with pancreatitis. Contrast roentgenograms did not reliably show the superficial mucosal disease. Duodenal ulcerations were present in 12 patients and developed on a background of diffuse superficial mucosal injury. Other complications in the patient's postburn course influenced disease progression. Hemorrhage occurred in six patients with duodenal disease, usually originating from a posterior duodenal ulcer. Uncomplicated ulcers invariably healed within five weeks after diagnosis.
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PMID:Acute duodenitis and duodenal ulceration after burns. Clinical and pathological characteristics. 107 60

Between September 1984 and August 1991, 265 whole pancreaticoduodenal transplants were done at our institution, with bladder drainage of exocrine secretions through a duodenocystostomy. Seventeen patients subsequently underwent conversion from bladder to enteric drainage at 2 to 64 months after transplant. Eight conversion procedures were done to correct chronic intractable metabolic acidosis due to bicarbonate loss from the allograft: seven to alleviate severe dysuria, presumed secondary to the action of graft enzymes on uroepithelium; one to prevent recurrent allograft pancreatitis, presumed secondary to back pressure from the bladder; and one because of graft duodenectomy for severe cytomegalovirus duodenitis with perforation. None were done to correct technical complications from the initial transplant operation. The conversions were done by dividing the graft duodenocystostomy, then re-establishing drainage through a graft duodenal-recipient jejunal anastomosis. A simple loop of recipient jejunum was used for the duodenojejunostomy in 15 cases, and a Roux limb in two. One of those two cases had a previously created Roux limb that was available for use. The other was in the patient who underwent graft duodenectomy and subsequent mucosa-to-mucosa anastomosis of the pancreatic duct to a newly created Roux limb of jejunum. All patients experienced relief of their symptoms after operation. Two patients had surgical complications (12%), an enterotomy in one case, which was closed operatively, and an enterocutaneous fistula in the other case, which healed spontaneously with bowel rest and parenteral nutrition. The drawback to conversion is loss of urine amylase as a marker for rejection, particularly in recipients of solitary pancreas grafts (n = 5). In recipients of simultaneous pancreas-kidney (SPK) allografts (n = 12), the kidney can still be used to monitor for rejection (two with follow-up < 1 year, 10 with follow-up > 1 year). None of our solitary pancreas recipients, however, have lost graft function (follow-up, 10 to 36 months). The only pancreas allograft loss was in an SPK recipient who also rejected the kidney 6 months after conversion. She received a second SPK transplant with enteric drainage, and is insulin independent and normoglycemic 10 months after retransplantation. Patients converted for metabolic acidosis tended to have impaired renal function (mean creatinine, 2.14 +/- 0.98 mg/dL at time of conversion) due to chronic rejection, progression of native kidney diabetic nephropathy, or cyclosporine toxicity, and possibly could not compensate for bicarbonate loss from the pancreas allograft.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Conversion of exocrine secretions from bladder to enteric drainage in recipients of whole pancreaticoduodenal transplants. 146 20

In patients with chronic pancreatitis (CP) (cholepancreatitis and primary recurrent pancreatitis), a moderate decrease of urocholecystokinin (UCK) excretion as a criterion for incretion of cholecystokinin-pancreozymin (CK) by duodenal endocrine cells was recorded in the presence of concomitant atrophic duodenitis. The beta-adrenoblocker obsidan, the blocker of m-cholinergic receptors gastrozepin, the antagonist of calcium channels finoptin and the synthetic analog of endogenous opiates dalargin reduced excretion of UCK in CP exacerbation. The decrease of CK incretion can be viewed as one of the mechanisms of the therapeutic action of these drugs in CP exacerbations. In the stage of CP remission, calcium gluconate consistently increased basal and intraduodenal oil (as a realizer of CK incretion) infusion-stimulated excretion of UCK. The enhancement of duodenal incretory activity is an essential mediating mechanism by which calcium gluconate stimulates pancreatic enzyme excretion.
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PMID:[Cholecystokinin incretion and the pharmacological effects on it in patients with chronic pancreatitis]. 150 78

Morphological and endoscopic features of a chronic gastroduodenitis combined with dyskinesia of bile ducts and pathology of hepatobiliary system and pancreas (chronic cholecystocholangitis, cholecystopancreatitis, "reactive" pancreatitis) are studied in 72 children. The most severe changes in the duodenal mucosa (chronic atrophy or, less frequently, diffuse duodenitis) were found in patients with dyskinesia of bile ducts and with disturbances of hepatobiliary system and pancreas. A characteristic feature of chronic duodenitis in patients with diseases of hepatobiliary system and pancreas lymphangiectasia in the villi.
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PMID:[Morphological and endoscopic characteristics of chronic gastroduodenitis in children with lesions of the hepatobiliary system and pancreas]. 370 92

Seven foals aged 18 days to 3 1/2 months had either single or multiple full-circumference segments or long antimesenteric bands of necrotizing duodenitis, sharply delineated from adjacent viable duodenum. Perforation of the necrotic wall had occurred in all foals, leading to acute fibrinous peritonitis. On the mucosal surface severe diffuse, acute inflammation and ulceration involved the anterior half of the duodenum. Two further foals, aged 28 and 30 days, had lesions that are believed to be a chronic form of this disease. Both foals had a thickened duodenal wall, with large areas of mucosa replaced by granulation tissue. In addition one had several strictures associated with firm adhesions between the duodenal serosa and adjacent structures, together with ascending cholangiohepatitis and pancreatitis. Eight foals had gastric ulcers that were considered to be of less significance than the duodenal lesions. No etiologic agent could be found by aerobic or anaerobic bacterial culturing, negative contrast electron microscopy for viruses, or immunofluorescence staining for equine herpesvirus 1, equine adenovirus, or equine coronavirus. The possible involvement of non-steroidal anti-inflammatory drugs is discussed.
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PMID:Ulcerative duodenitis in foals. 664 36

The complex clinico-roentgenological examination of 232 patients with cholelithic disease enabled the authors to reveal different complications (duodenitis, pancreatitis, biliodigestive fistulas, stones in the ampullar portion of the common duct cholelithic small intestine ileus) in 52 (22,7%) of them. The relaxation duodenography was found to be a sufficiently informative method for diagnosing complications of the cholelithic disease.
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PMID:[Diagnosis of various complications of cholelithiasis]. 716 13

Seven cases of Crohn's disease of the duodenum are presented. They made up 2% of 350 cases of Crohn's disease seen over a period of 15 years. Mean age at onset of Crohn's disease was 22 years (range, 13--47). All patients had other, and most patients severe, lesions elsewhere in the alimentary tract. In three patients the duodenal lesion appeared simultaneously with or within a year of lesions elsewhere, in four cases not until 4 to 15 years later. The period of observation after detection of regional duodenitis was 2 to 14 years; mean, 8 years. The commonest complaint due to duodenitis was epigastric pain. It was present in everyone. Gastrointestinal bleeding rarely occurred. Complicating pancreatitis was not seen. Pathophysiologic abnormalities (decreased vitamin B12 and iron absorption, abnormal protein loss) depended more on the extraduodenal extension of Crohn's disease than on the duodenal lesion. In three patients duodenal obstruction required a bypass operation (gastrojejunostomy or duodenojejunostomy). The same three patients and three other of the series were subjected to other surgical treatment, including ileal resection and, in four cases, subtotal colectomy. Two patients died, one of pneumonia in his home and one in her home town of, probably, acute gastroenteritis complicating a severe short-bowel syndrome. The prognosis in this series seemed to be worse than in Crohn's disease in general, not because of the duodenal lesion but because of its association with severe lesions elsewhere in the gastrointestinal tract.
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PMID:Crohn's disease of the duodenum. 720 78

The authors carried out studies on 16 rabbits - 10 experimental and 6 control with implanted duodenal fistula. They poured for a period of 4 days through the fistula the duodenal content of 6 sick persons with acute and chronic relapsing pancreatitis into the duodenum of the experimental animals and the content of 2 healthy persons-to the animals of the control group. After each pouring the activity of pancreatic and intestinal enzymes was determined in sera and duodenal contents of the rabbits. The duodenum, pancreas, liver and kidneys were examined histomorphologically after killing the experimental animals. The obtained results showed that there were no changes in the enzyme activity and morphologic picture of the organs after pouring duodenal content of healthy persons. The enzyme activity was reduced in the duodenal content of the experimental animals, but in the sera was increased. Pancreatitis, duodenitis, fatty dystrophy of liver and parenchymatous dystrophy of kidneys was established histomorphologically. The authors suggest the appearance of some toxic substances in the duodenal content of sick persons with acute and chronic relapsing pancreatitis.
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PMID:[Pathogenic action of the duodenal contents in acute and chronic exacerbated human pancreatitis]. 725 19


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