Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cystadenoma and cystadenocarcinoma comprise the majority of the true neoplastic cysts of the pancreas. Five cystadenomas and two cystadenocarcinomas of the pancreas were found in a review of the clinical records of the University of Minnesota Hospitals and the Minneapolis Veterans Administration Hospital. The report of these cases serves to review the clinical and pathological features of these neoplasms. These rare neoplastic cysts occur predominantly in women and are not associated with a history of trauma, alcoholism, or pancreatitis. They produce symptoms by compression of neighboring organs and are slow growing, often attaining large size. With complete excision the results of surgical treatment are usually good.
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PMID:Cystadenoma and cystadenocarcinoma of the pancreas. 76 24

Five patients with cystadenoma of the pancreas were seen during a period of 22 years at this institute. This rare benign tumor occurred predominantly in middle age women, with the presenting symptoms of pain and an epigastric mass, but without a history suggestive of pancreatitis or abdominal trauma. Selective celiac and superior mesenteric antiography is helpful in establishing the diagnosis. If this cystic tumor is not recognized and adequately treated, the surgeon may miss the opportunity for cure. Cystadenoma should be suspected when a cystic mass arising from the body or tail of the pancreas is encountered without evidence of metastases. Although surgical extirpation is the preferable treatment, undue risks should not be undertaken because of the slow growth rate of this benign tumor. Due to the known association of this tumor with other malignant lesions, diabetes mellitus as well as multicystic tumors of the liver and kidneys, these patients should be thoroughtly investigated.
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PMID:Cystadenoma of the pancreas. 112 84

Cystadenomas occur rather rarely among the cystic lesions of the pancreas, but they nevertheless require special attention. These cystadenomas do have a tendency for malignant degeneration, especially their mucinous form with papillary proliferation of the epithelium; insofar cystadenomas have to distinguished from retention nor pseudocysts, resulting from pancreatitis or from traumatic lesions of the pancreas. Differentiation of cystadenomas and other cysts can neither be achieved by preoperative diagnostic procedures nor by macroscopic findings during surgery. Diagnosis however can be established after biopsy during surgery. A cystadenoma has to be suspected especially in women of middle age, who do not have any history of pancreatitis, abdominal trauma or alcoholism, if the lesion is localized in the corpus or tail are of the pancreas. Cystadenoma have to be treated as potentially malignant tumors. The therapy of choice is excision far out in normal tissue; this is the only way to prevent relapses and to avoid transition of the lesion into a carcinoma. Thus, it has to be postulated for all patients who are being operated upon because of cysts of the pancreas that multiple biopsies should be done from various parts of the cystic wall during surgery and that drainage of the cyst should be performed only if a cystadenoma can be excluded.
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PMID:[Cystadenoma of the pancreas, a potentially malignant tumor (author's transl)]. 730 May 47

A case of pancreatic mucinous cystadenoma with borderline malignancy in a 70 year-old woman is presented. Cystadenomas are rare neoplasms, but should be suspected in patients with cystic lesions of the pancreas and no previous history of pancreatitis or abuse of alcohol.
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PMID:[Cystadenomas of the pancreas]. 860 21

A 43-year-old man presented with abdominal discomfort caused by relapsing pancreatitis. Radiological examination revealed a multilocular cystic mass in the tail of the pancreas, which was resected. Gross examination showed a multilocular cystic lesion measuring 2.5 cm in diameter and containing clear fluid. Microscopically, a mucinous cystadenoma with mesenchymal stroma was diagnosed. The lesion showed two different components: a cyst lined by a columnar, mucin-secreting epithelium and a moderate cellular stroma composed of spindle cells. The stromal element appeared similar to primitive mesenchyme. Immunohistochemical staining confirmed this origin through vimentin expression and showed moderate to strong nuclear staining with oestrogen and progesterone receptor antibodies. Cystadenomas are rare tumours of the pancreas, but mesenchymal stroma is uncommon in such tumours; it is more frequently described in the liver and the bile ducts, and primarily in women.
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PMID:A pancreatic mucinous cystadenoma in a man with mesenchymal stroma, expressing oestrogen and progesterone receptors. 950 65

Echo-enhanced sonography is increasingly being used for differential diagnosis of pancreatic tumors. Ductal carcinomas are often hypovascularized compared with the surrounding tissue. On the other hand, neuroendocrine tumors are hypervascularized lesions. Tumors associated with pancreatitis have a different vascularization pattern depending on inflammation and necrosis. Cystadenomas frequently show many vessels along the fibrotic strands. Pancreatic tumors have a different vascularization pattern in echo-enhanced sonography. These characteristics can be used for differential diagnosis. However, histology is the standard of reference.
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PMID:Echo-enhanced sonography--an increasingly used procedure for the differentiation of pancreatic tumors. 1529 93

Echo-enhanced ultrasound is a newly available imaging modality for the evaluation of pancreatic lesions. Neoplasms of the pancreas tend to have a characteristic vascularization pattern. Adenocarcinomas are often hypovascularized as compared to the surrounding tissue. On the other hand, neuroendocrine tumors are hypervascularized lesions. Masses associated with pancreatitis have a different vascularization pattern depending on the degree of inflammation and necrosis. Cystadenomas frequently show many vessels along fibrotic strands. Data from prospective studies have demonstrated that based on these imaging criteria, the sensitivity and the specificity of echo-enhanced sonography in diagnosing the degree of differentiation of pancreatic masses are equal to, or greater than, 85% and 90%, respectively. In conclusion, pancreatic tumors have a different vascularization pattern in echo-enhanced ultrasound. These characteristics can be used with high a diagnostic accuracy for differentiation.
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PMID:Contrast-enhanced ultrasound in the diagnosis of pancreatic tumors. 1709 37