Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A group of 159 dogs divided in 8 sub-groups were studied, in regard to pancreatitis, the purpose of the study was to investigate the participation of the automatic nervous system in the course of acute pancreatitis. The procedures and the results were as follows: 1. Pancreatitis was induced in two forms: a) Injection of gallbladder bile, from the same animal to the pancreatic duct. b) Blind duodenal loop with exclusion of the distal duodenum through the pylorus. In both cases acute pancreatitis was obtained. Fat necrosis was predominant in type a, and hemorrhagic lesions in type b. 2. The anesthetic block of the celiac plexus controlled the pain and shock. The animals were in good general conditions but there were no changes in the pathological process of the pancreas. The same results were noted in surgical resections of splanchnic trunks. 3. When the surgical resections of splanchnic nerves was followed by a waiting period of 20 days from the production of pancreatitis there were no changes in the gland. 5. Vagotomy previous to pancreatitis does not have protector effects in the induction of pancreatitis. 6. Continuous perfusion of E.V. novocaine was of extreme utility. The animals remained without pain and the process remained stable when it was given in the initial face of edema. 7. The enzyme inhibitor (Trasylol) given in the first 24 hs. does not prove to be valuable. Due to the fermentative derangement the condition of the animals was better maintained in relation to the comparative animals.
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PMID:[Acute pancreatitis. Neurovascular and microcirculatory changes. Pathogenic and therapeutic study]. 246 25

We report the case of a 60 year old lady suffering from celiac disease and autoimmune cirrhosis who developed exocrine pancreatic insufficiency with canalicular lesions consistent with chronic pancreatitis. Celiac disease is known to be associated with either pancreatic insufficiency or liver disease, but association of all three diseases has not yet been described. We suggest that chronic pancreatitis be added to the list of idiopathic inflammatory pancreatitis of possible autoimmune origin, enabling to explain the pathophysiology of all three disorders with one hypothesis.
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PMID:[Celiac disease, autoimmune cirrhosis, chronic pancreatitis: apropos of a triple association]. 262 89

We report a case of subacute pancreatitis in a 26-year-old woman, who underwent partial pancreatectomy after a two-week history of abdominal pain. The patient had a long history of allergy. She did not show any well recognized cause of acute or chronic pancreatitis. This patient was thought to have eosinophilic pancreatitis because of the presence of a prominent eosinophilic infiltrate in the resected pancreas. Eosinophilic infiltration of the pancreas has been reported very rarely in the literature, and is usually associated with more generalized disease. In our case there was no extrapancreatic involvement, as shown by repeatedly normal blood eosinophil counts, and by histologically normal spleen, celiac lymph nodes, and gastroduodenal biopsies. We suggest that an allergic mechanism might be responsible for this patient's disease, based on past history of allergic manifestations and the important increase in her serum IgE.
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PMID:[Eosinophilic pancreatitis: a rare manifestation of digestive allergy?]. 280 7

We describe a new method for the insertion of an indwelling catheter into the region of the celiac ganglion in order to achieve long-lasting pain relief. A simple nylon catheter, of the type usually used for performing epidural catheter techniques, is placed into the prevertebral space opposite the first lumbar vertebra. The applications of the catheter were tested in a prospective study. Catheter insertion was performed in five patients suffering from carcinoma or pancreatitis. The catheter remained in place for an average of 5.8 days. The new technic was found to be successful not only for pain therapy but also to be a useful supplement for anaesthesia during laparotomy.
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PMID:[Continuous block of the celiac plexus]. 357 13

Obliteration of the fat plane surrounding the superior mesenteric artery has been described as characteristic of pancreatic carcinoma. To determine the specificity of this and other computed tomography findings in the pancreas and peripancreatic region, scans of 86 patients were reviewed without clinical history. Diagnoses included pancreatitis (26 patients); pancreatic adenocarcinoma (14 patients); lymphoma (17 patients); metastatic nonpancreatic carcinoma (14 patients); and normal findings (15 patients). Confluent adenopathy could not be reliably differentiated from a pancreatic mass except when adenopathy separated the common bile duct from the duodenum. Retrocrural adenopathy was unusual with pancreatic carcinoma. The fat plane surrounding the superior mesenteric artery was obliterated with pancreatic carcinoma (36%), nonpancreatic carcinoma (29%), and lymphoma (24%), but not with pancreatitis, although perivascular edema was seen in 19%. Evaluation of the celiac axis was less rewarding. Obliteration of the superior mesenteric artery fat plane is a sign of malignancy, but it is not specific for pancreatic carcinoma. We propose that the superior mesenteric artery origin be considered within a paraaortic space, separate from the anterior pararenal space. This explains its characteristic lack of involvement by pancreatitis.
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PMID:The superior mesenteric artery fat plane: is obliteration pathognomonic of pancreatic carcinoma? 360 49

In 35 pancreatectomized dogs, the donor pancreatic tail was transplanted by end-to-side anastomoses between the portal vein and the celiac axis to the femoral vessels of the host. To influence the exocrine pancreas secretion of the graft we applied different methods of drainage of the pancreatic duct: open drainage to the abdominal cavity (Group I, n = 15), occlusion of the duct by Neoprene (Group II, n = 12) and by Ethibloc (Group III, n = 8). Main complications were rejection crisis and pancreatitis. Segmental pancreas allografts were rejected in group I within about 34 days, in group II within about 11 days, in group III within about 13 days. The fasting blood glucose levels in all 3 groups returned to normal 2 days after transplantation. Better results were achieved in the open-duct and Ethibloc-occluded grafts. 3 weeks after transplantation, a delayed and diminished increase of insulin concentration after glucose stimulation was observed compared to the dogs of the control group. Peak insulin values were significantly higher (p 0.01) in group I compared to group II. Histologically acinar atrophy with replacement by fibrous tissue occurred in all groups after 2 weeks. The least severe histological changes were observed in group II. The best results were achieved by the open-duct technique, whereas the occlusion groups showed a high rate of early complications like rejection, venous thrombosis and pancreatitis.
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PMID:[Allogeneic segmental heterotopic pancreas transplantation in the dog with reference to various drainage technics]. 392 96

Trypsin and chymotrypsin concentrations were determined in 180 spot stool specimens from 110 control patients in hospital. The lower limit of normality for each enzyme was placed at the 5% level: 95% of this population excreted feces containing more than 100 mug. of chymotrypsin and 30 mug. of trypsin per g. of feces. Chymotrypsin concentrations appeared to be a more reliable guide to pancreatic function than trypsin concentrations.Fecal chymotrypsin concentrations were subnormal in five patients with chronic pancreatitis, borderline in one patient with relapsing pancreatitis, subnormal in one patient after pancreatectomy, and subnormal in five of nine with carcinoma of the pancreas. Subnormal concentrations of fecal chymotrypsin were found in seven of 21 patients with chronic liver disease related to alcoholism, eight of 32 with a partial gastrectomy, three of 10 with adult celiac disease and five of 16 with psoriasis.It appears that the determination of fecal chymotrypsin concentrations provides a valuable screening test for pancreatic exocrine deficiency. However, normal results may be found in some patients with pancreatic disease and subnormal values may occur in some patients with other conditions.
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PMID:Fecal chymotrypsin and trypsin determinations. 555 Mar 76

The influence of a short-term ischemia of the pancreas for the pathogenesis of a hemorrhagic necrotising pancreatitis was investigated in 28 mongrel dogs. Ischemia of the pancreas in 20 minute intervals repeated three times did not leave any macroscopic, histologic or electron microscopic changes and no alterations of the level of the alpha-amylase, the lipase, and the glucose in the serum. An ischemia of 20 minutes' duration by starvation of the celiac artery and the superior mesenteric artery produces a hemorrhagic necrotising pancreatitis under the precondition of a following pancreatic edema by ligature of the pancreatic duct and secretomotoring with secretin and pancreozymin. The necrosis starts histologically in the perilobular adipose and affects the parenchyma later. Whether the lipase is the starting enzyme for the acute pancreatitis or only conditions the early adipose necrosis should be discussed after these findings. Already a fugitive pancreatic edema produces a hemorrhagic necrotising pancreatitis after previous ischemic damage.
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PMID:[Animal experiment studies on the role of ischemia in the pathogenesis of acute pancreatitis]. 633 88

Hepatic artery infusion chemotherapy is a recognized treatment of unresectable hepatic neoplasms. Because the arterial supply to the stomach and duodenum originates from the celiac and hepatic arteries, unavoidable infusion of the gastroduodenal and right gastric arteries may result in gastrointestinal complications. Of 174 patients (266 infusions) treated with hepatic artery infusion chemotherapy during a 12 month period, 18 developed severe dyspepsia. Ten of these 18 patients had gastrointestinal pathology documented by either endoscopy or upper gastrointestinal series; six had gastric ulcer and gastritis, two had duodenal ulcer, one pyloroduodenitis, and one pancreatitis. Endoscopically, the hepatic artery infusion chemotherapy-induced ulceration and gastritis were located in the distribution of the infused arteries. Radiographically, the gastric abnormalities ranged from typical benign ulcers to a pattern of multiple ulcerations with nodular fold mimicking malignancy. Angiographic correlation could be made on eight of the 10 patients. Vascular trauma, observed in five of these eight patients, seemed to contribute to gastrointestinal complications in hepatic artery infusion chemotherapy.
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PMID:Hepatic artery infusion chemotherapy: gastroduodenal complications. 645 49

The authors examined 40 patients with chronic ischemic pancreatitis without concomitant pathology of the alimentary organs in order to define the features of the disease clinical picture and progress. It was found that patients with disseminated atherosclerosis, especially when it is coupled with essential hypertension, and with extravasal stenosis of the celiac trunk are predisposed to the development of chronic ischemic pancreatitis. Factors promoting pancreatic ischemia include abnormalities of the blood rheological properties seen in vascular pathology and alimentary hyperlipidemia.
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PMID:[Various characteristics of chronic ischemic pancreatitis]. 652 92


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