Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030201 (Postoperative pain)
 1,085 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Postoperative pain relief with epidural morphine and buprenorphine was studied in 33 patients following hepatectomy. Morphine 2mg or buprenorphine 0.06mg in 10ml of normal saline was administered through an epidural catheter inserted at the Th10-11 or L3-4 interspace. Morphine injected at the lumbar level, as well as that injected at the thoracic level produced excellent and long-lasting (20.8 +/- 8.6 hours) pain relief. Respiratory rate decreased significantly following epidural morphine at the L3-4, but PaCO2 did not change. Buprenorphine injected at the thoracic level produced good and long-lasting (22.6 +/- 9.9 hours) pain relief, although buprenorphine injected at the lumbar level produced incomplete analgesia. The epidural administration of morphine 2mg at L3-4 or buprenorphine 0.06mg at Th10-11 may be recommended for postoperative analgesia following hepatectomy.
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PMID:[Epidural morphine and buprenorphine for postoperative pain relief after hepatectomy]. 230 47

Postoperative pain relief obtained by the thoracic epidural injection of 5 or 10 mg morphine was assessed in two groups of elderly patients scheduled for abdominal surgery. In the first group of patients (n = 37, mean age 73.2 +/- 9.9 years), five epidural morphine provided a good and prolonged analgesia for an average duration of 24.5 hours. All patients showed a remarkable lucidity and remained fully cooperative when receiving chest physiotherapy. In the second group (n = 11, mean age 65.3 +/- 11.2 years), ten mg epidural morphine induced a more powerful analgesia lasting on average 38 hours. In this group however, fine patients developed a respiratory depression, often delayed in onset, associated with increased PaCO2 levels and/or bradypnea, requiring treatment with narcotic antagonists. Also an important degree of sedation was observed. These results emphasize the inherent dangers of ventilatory depression of high dose thoracic epidural morphine treatments in elderly patients.
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PMID:Epidural morphine for postoperative analgesia following abdominal surgery in elderly patients. 709 Jul 24