Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030201 (Postoperative pain)
1,085 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Using mesh or a synthetic prosthesis during tension-free inguinal hernia repair has been shown to be safe and effective. We compared the final outcome in treating inguinal hernia in 45 patients using three different prosthetic materials: 15 patients underwent tension-free inguinal hernia repair using Prolene (polypropylene) mesh, 15 using Vypro (polyglactin and polypropylene) mesh, and 15 with Surgisis-a new bioactive material derived from porcine small intestinal submucosa. The aim of this study was to evaluate the safety and efficacy of tension-free inguinal repair using Surgisis, comparing it with conventional prosthetic materials. From January 2003 to December 2003, 45 male patients underwent Lichtenstein inguinal hernia repair. Median follow-up was 12 months, with a range of 1-16 months. Each patient underwent ultrasound evaluation of the inguinal region 1 month after surgery. All the procedures were completed under local anesthesia. There were no intraoperative complications, and all patients were discharged home the same day of surgery. No recurrent hernias and wound infections were observed in our post-operative follow-up period. Postoperative pain (visual analog score) and discomfort were lower in patients with Surgisis mesh. There was no statistically significant difference between the groups in terms of overall early and late complications; however, there was a tendency toward a higher incidence of pain and discomfort in Vypro and Prolene group. The median time to full recovery was significantly shorter in the Surgisis group. Surgisis mesh seems to be a promising new prosthetic material for hernia repair. Long-term follow-up is necessary to confirm these preliminary results.
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PMID:Comparison of three different mesh materials in tension-free inguinal hernia repair: prolene versus Vypro versus surgisis. 1646 43

Three hundred patients underwent inguinal hernia repair from January 2003 to December 2004; 40 patients, randomly selected, received the PHS (Prolene Hernia System) mesh. Surgery was performed under local anesthesia in 80% of cases and under spinal anesthesia in the remaining 20%. There were 29 men and 11 women; mean age was 58,5 years (range 39-78). Postoperative pain was light and morbidity was low; all patients had early return to normal activities. Particularly, there were differences between the self-employed and the employees: the former began work again 2-4 days after surgery in 85% of cases, while the latter began after 15-20 days. Immediate complications were rare and always minor: they included seroma (1%) and ecchymosis (1%). Follow-up examinations did not show any recurrences.
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PMID:[Inguinal hernioplasty with PHS: our experience]. 1660 36

For this study, 66 patients with a preoperative diagnosis of unilateral primary inguinal hernia were randomized to undergo laparoscopic totally extra peritoneal (TEP), laparoscopic transabdominal (TAPP), or open inguinal hernia repair with polypropylene mesh (Lichtenstein type). Both the operative team caring for the patient postoperatively and the patient were blinded to the operative approach by placement of a large dressing covering the abdomen, which was not removed until postoperative day 3. The patients recorded their pain level on a visual analog pain scale daily. Medication usage also was recorded. All patients were seen at 7-day intervals until they returned to work. The patients were interviewed during their postoperative visits by an investigator blinded to the operative approach and questioned regarding their ability to return to work and their pain levels. The average number of lost work days in all the groups was 12, and there was no significant difference between the three groups (p = 0.074). The average operating time for the TAPP procedure was 59 min, less than the time required to complete either the TEP or the Lichtenstein approach, which had equivalent operative times (p = 0.027). The material cost was significantly lower for the Lichtenstein repair (1,200 dollars less) than for either of the laparoscopic approaches, a saving primarily related to consumable operating room supplies. The TEP repair costs were minimally higher than those for the TAPP repair (125 dollars more). No significant differences were noted in the postoperative pain scales, and the use of postoperative oral analgesics was equivalent. The higher operative costs noted for the laparoscopic hernia repairs were not offset by a shortened convalescence. Postoperative pain appears to be equivalent regardless of the operative approach chosen and is easily managed with oral analgesics.
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PMID:The economic impact of laparoscopic inguinal hernia repair: results of a double-blinded, prospective, randomized trial. 1723 21

Despite being one of the commonest surgical procedures, few methodologically suitable evaluations of inguinal hernia repair have been conducted in France. Between September 1995 and November 2000 men with inguinal hernias at 7 surgical centers were randomly assigned to open or laparoscopic repair. The primary endpoint was recurrence of hernias at two years and secondary endpoints were complications and postoperative pain (Visual Analogic Score). Of 404 patients assigned to one of the two procedures, 390 were available for the analysis. Median follow-up was 2.8 years for open surgery (Shouldice 98%) and 2.3 years for laparoscopy (TAP 55%; TEP 45%). Two-year follow-up was 66%. Recurrences were more common in the laparoscopic group (15.5%) than in the open group (6%) odds ratio 2.75; 95% confidence interval 1.20-6.85. This difference was statistically significant for direct hernias exclusively. The three severe intraoperative complications were reported in the laparoscopic group. The rate of local complications at 8 and 30 postoperative days were not different between the two techniques, however 8 of 9 patients with testicular pain were in the laparoscopic group. Postoperative pain at one month was less severe in the laparoscopic than in the open group (VAS 1.41.9 and 3.12.6 respectively). The rate of patients with postoperative pain (VAS>2) at one year was not related to the open or laparoscopic technique (overall 8.5%). Mean PREoperative VAS of patients with longterm postoperative pain was higher than PREoperative VAS of patients without postoperative pain, 3.9 and 2.2 respectively. Mean operating room occupation times were 11637 min and 16965 min for open and laparoscopic surgery respectively. Subject to limitations associated with the present study follow-up, open surgery might be superior to laparoscopic surgery for inguinal hernia repair.
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PMID:[Inguinal hernia repair. A randomized multicentric study comparing laparoscopic and open surgical repair]. 1760 21

The aim of the study is to evaluate the efficacy of post-incisional wound infiltration with levobupivacaine in preventing the postoperative pain associated with inguinal hernia repair in children. Thirty boys, ASA I - II, aged 2 - 12 yrs., undergoing unilateral inguinal hernioplasty under general anaesthesia as day-case patients were allocated randomly to have postoperative analgesia either with post-incisional wound infiltration with levobupivacaine 1.25 mg/kg or with paracetamol 30 mg/kg administered rectally. Postoperative pain was assessed initially in the Post-Anaesthesia Care Unit and on the ward by an observer and afterwards for the next 24 h by the parents, using the Poker Chip Tool for preschoolers and the Visual Analogue Scale for older children, respectively. Postoperative pain was managed by giving paracetamol. The duration of the postoperative analgesia was estimated based on the time when rescue analgesia was first given. Assessment of the quality of postoperative analgesia was based on the children's behaviour. The wound infiltration group showed an increased duration of postoperative analgesia (p < 0.001) and early mobilisation, while the efficacy of postoperative analgesia tended to be more adequate, although no statistically significant difference was noted.
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PMID:Wound infiltration with levobupivacaine: an alternative method of postoperative pain relief after inguinal hernia repair in children. 1780 25

Extended spinal anaesthesia using a spinal micro-catheter was used as a primary method of anaesthesia for elective colorectal cancer surgery in 68 high risk patients over a 14-year period in our institution. The technique was also useful in eight elective and 13 emergency abdominal surgeries. All patients suffered from severe chronic obstructive airway disease requiring multiple inhalers and drugs (ASA III). Thirty nine of these patients also suffered from angina, myocardial infarction, diabetes and other systemic diseases (ASA IV). Surgery included right hemicolectomy, left hemicolectomy, total colectomy, sigmoid colectomy, Hartman's resection, anterior resection of rectum, abdominoperineal resection, cholecystectomy (open and laparoscopic) and obstructed inguinal hernia requiring laparotomy. Spinal anaesthesia was performed under strict aseptic conditions with a 22 gauge spinal needle with a mixture consisting of 2.75ml of 0.5% heavy bupivacaine and 0.25ml of fentanyl (25microg). This was followed by placement of a spinal micro-catheter and the duration of anaesthesia was extended by intermittent injection of 0.5% isobaric bupivacaine. Brief hypotension occurred in 12.4% of patients during the establishment of anaesthetic block height to T6-7 and was duly treated with intravenous administration of fluid and ephedrine hydrochloride. Good anaesthesia resulted in all patients except for brief discomfort in some patients during hemicolectomy surgery possibly due to the dissection and traction on the peritoneum causing irritation to the diaphragm. The use of sedation was avoided. General anaesthesia was administered in one patient and this patient required postoperative ventilation and cardiovascular support in the Intensive Care Unit. The spinal micro-catheter was removed at the end of surgery. Postoperative pain relief was obtained by administering intravenous morphine through a patient controlled analgesia machine in the critical care ward area (High Dependency Unit). There was a low incidence of minor postoperative side effects such as nausea (14.6%), vomiting (7.9%), minor post dural puncture headache (5.6%) and pruritus (5.6%). We conclude that spinal anaesthesia with a micro-catheter may be used as a primary method of anaesthesia for colorectal cancer surgery and other major abdominal surgery in high-risk patients for whom general anaesthesia would be associated with higher morbidity and mortality.
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PMID:Spinal anaesthesia with a micro-catheter in high-risk patients undergoing colorectal cancer and other major abdominal surgery. 1803 40

Postoperative pain is a major obstacle in hernia repair surgery, and the choice of clinically efficacious surgical technique should also result in the least postoperative pain and patients' quality of life (QoL). The aim of this prospective randomized study was to compare two surgical techniques for open inguinal hernia repair by assessing the patients' QoL. Men (18-to-75 years old) with primary unilateral inguinal hernia underwent Mesh Plug (MP; n = 156; Bard (PerFix Plug, CR Bard Inc, Murray Hill, NJ) and Shouldice (S; n = 144) techniques. We evaluated: 1) Intensity of postoperative pain (visual analog scale [VAS]) and 2) quality of life (QoL; Medical Outcomes Study Short-Form 36 [SF-36]). Patients undergoing MP had significantly lower VAS scores on postoperative days (POD) 1 (22.1 vs 27.4, p = .003) and 2 (13.2 vs 21.4, p < .0001) compared to those in the S group. The QoL was also improved in patients undergoing MP on PODs 8 and 45. Total duration of operation, length of hospital stay, and cessation of normal activities were significantly shorter in the MP group. Compared to the S technique, the MP technique results in significantly less postoperative pain and improved QoL.
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PMID:Prospective randomized study comparing quality of life after shoudice or mesh plug repair for inguinal hernia: short-term results. 2302 73

Laparoscopic inguinal hernia repair has been shown to have multiple advantages compared with open repair such as less postoperative pain and earlier resume of daily activities with a comparable recurrence rate. We speculate robotic inguinal hernia repair may yield equivalent benefits, while providing the surgeon added dexterity. One hundred consecutive robotic inguinal hernia repairs with mesh were performed with a mean age of 56 years (25-96). Fifty-six unilateral hernias and 22 bilateral hernias were repaired amongst 62 males and 16 females. Polypropylene mesh was used for reconstruction. All but, two patients were completed robotically. Mean operative time was 52 minutes per hernia repair (45-67). Five patients were admitted overnight based on their advanced age. Regular diet was resumed immediately. Postoperative pain was minimal and regular activity was achieved after an average of four days. One patient recurred after three months in our earlier experience and he was repaired robotically. Mean follow-up time was 12 months. These data, compared with laparoscopic approach, suggest similar recurrence rates and postoperative pain. We believe comparative studies with laparoscopic approach need to be performed to assess the role robotic surgery has in the treatment of inguinal hernia repair.
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PMID:Robotic Inguinal Hernia Repair: Technique and Early Experience. 2777 96

Laparoscopic hernia repairs are used increasingly in children.The purpose of this single-center cohort observational research study was to analyze the outcome of children treated surgically for unilateral or bilateral inguinal hernia using laparoscopy.We did a STROBE-compliant retrospective outcome analysis of pediatric, laparoscopic hernia repair. Consecutive laparoscopic herniorrhaphies in 123 children done between March 2, 2010, and March 1, 2014, were included in this analysis. Data analysis was based on reviewing the hospital records and a prospective questionnaire. We evaluated postoperative hernia recurrence rate, occurrence of postoperative complications, duration of postoperative pain medication, and wound cosmesis.We first performed laparoscopic inguinal herniorrhaphy according to the techniques described by Schier et al and Becmeur et al in March 2010. We treated 46 girls and 77 boys with laparoscopically confirmed inguinal hernias, and their ages ranged from 0 to 16 years. Of these, 77 children suffered from unilateral hernias, 30 from unilateral hernias with contralateral patency of the vaginal process, and 16 from indirect bilateral hernias. The median follow-up interval was 38 months (range: 13-58 months). Overall, 8 (6.5%) of these 123 patients experienced a recurrence of the inguinal hernia. Two patients (1.6%) suffered a postoperative infection. Postoperative pain medication was administered by parents for 1 to 3 days in 67 (63.8%) of the 105 families who answered the question, and no pain medication was administered by 5 (4.0%) parents. Wound cosmesis was rated by the parents as invisible or barely visible in 106 (86.2%) of 123 patients and esthetically disturbing in 4 (3.2%) children.Laparoscopic inguinal hernia repair carries a learning curve and is safe and efficient in children thereafter. Further prospective studies are required to evaluate the long-term outcome of laparoscopic inguinal hernia repair in children.
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PMID:Single-center, retrospective study of the outcome of laparoscopic inguinal herniorrhaphy in children. 2938 43

Groin hernia in adults is a frequent affection in digestive surgery. Many repair techniques have been described to date, including laparoscopic surgery. Two methods are quickly adopted by the various practitioners for the surgical treatment of groin hernia using laparoscopy: laparoscopic totally extra-peritoneal (TEP) technique and laparoscopic transperitoneal inguinal hernia repair (TAPP). This study focused on the feasibility of groin hernia repair using coelioscopy, aiming to describe its outcomes in terms of recurrence and postoperative pain. We conducted a single-center, retrospective and cross-sectional study of patients who had undergone laparoscopic surgery for groin hernia repair in the Department of Surgery at La Rabta Hospital over a period of 8 years, from January 2006 to December 2013. The main evaluation criterion was hernia recurrence. Postoperative pain and complications were the secondary criteria of judgment. We collected data from 92 patients with 104 hernias, respecting the inclusion criteria in our study. The average age of patients was 48 years (19-83). TAPP was the most used technique: 94 TAPP (90%) versus 10 TEP. No intraoperative complication was reported. Conversion rate was 0. Operative mortality was also 0. Postoperative morbidity was 5% (5 patients). It included hematoma in 3 cases and serum in 2 cases. The mean lenght of stay in hospital was 1.2 days (1-4 days). Postoperative length of stay didn't exceed 2 days in 94% of patients. Only 2 patients had a recurrence. Postoperative chronic pain was reported only in 3 patients. Our study shows that laparoscopic surgery for groin hernia repair gives considerable comfort to our patients with regard to pain, length of stay in hospital and cessation of work. Outcomes are good and consistent with the results already published in the literature. This encourages surgeons to use these techniques and to monitor longer term outcomes.
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PMID:[Outcomes of laparoscopic surgery for groin hernia repair: our experience in Tunisia]. 2987 25


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