Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
261,466 document(s) hit in 31,850,051 MEDLINE articles (0.10 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 16176
MRI 3345
She 3284
Mol 3255
opioid receptor 1966
substance P 1787
cytokine 1409
calcitonin 1366
TNF 1190
TRPV1 981
collagen 926
axonal 924
GABA 919
tumor necrosis factor 907
IL-6 874
COX-2 849
Hip 823
insulin 798
NMDA receptor 785
ATP 783
gut 780
bradykinin 767
beta-endorphin 740
cyclooxygenase 734
C-reactive protein 719
Pol 704
hemoglobin 696
reserved 670
nerve growth factor 656
ASA 594
ankylosing spondylitis 578
cyclooxygenase-2 555
CO2 524
alkaline phosphatase 519
ANOVA 518
transient receptor potential vanilloid 1 506
sodium channel 500
calcium channel 463
lipopolysaccharide 457
cage 457
brain-derived neurotrophic factor 448
DRG 443
P2X 431
Mot 424
p38 422
TRPA1 415
glial fibrillary acidic protein 413
CSF 413
Gen 409
interleukin-6 404
CB1 374
fused 360
COX-1 358
IL-10 353
nitric oxide synthase 352
cannabinoid receptor 339
5-hydroxytryptamine 333
CB2 329
cholecystokinin 326
short form 325
chemokine 324
creatine kinase 323
dynorphin 320
Mal 317
oxytocin 316
somatostatin 314
c-fos 304
osteosarcoma 291
CGRP 286
inducible nitric oxide synthase 282
CRP 275
ERK 274
PCA 268
ESR 268
P2X3 260
T12 259
MAPK 258
OFQ 257
IL-1 254
T10 248
more...
Disease
chronic pain 14578
cancer 13058
depression 9782
tumor 7664
osteoarthritis 7193
arthritis 4530
cold 4267
migraine 4149
rheumatoid arthritis 3888
diabetes 3351
fibromyalgia 2963
metastases 2896
neuropathy 2682
pruritus 2566
ischemia 2131
hypertension 2106
carcinoma 1844
arthrodesis 1782
stroke 1757
breast cancer 1757
addiction 1589
osteoporosis 1558
Frey 1508
arthropathy 1493
peripheral neuropathy 1449
trigeminal neuralgia 1395
endometriosis 1354
obesity 1229
irritable bowel syndrome 1227
HIV 1191
epilepsy 1156
myocardial infarction 1149
multiple sclerosis 1143
bone metastases 1125
hernia 1122
sickle cell disease 1063
postherpetic neuralgia 1049
chronic pancreatitis 1016
prostate cancer 1010
dysphagia 991
sepsis 964
diabetic neuropathy 961
anemia 921
Parkinson's disease 890
synovitis 881
sepsis 870
AIDS 866
herpes zoster 856
osteomyelitis 851
claudication 851
radiculopathy 845
pancreatitis 839
regional pain syndrome 816
psychological distress 802
uterus 800
dysplasia 799
cognitive impairment 791
rash 785
adenocarcinoma 773
dementia 767
carpal tunnel syndrome 699
myelopathy 670
tuberculosis 670
lung cancer 669
ankylosing spondylitis 666
acute myocardial infarction 660
infertility 654
Best 654
chronic disease 648
infectious diseases 646
incontinence 646
Alzheimer's disease 642
scoliosis 637
myocardial ischemia 634
gangrene 634
sleep disturbances 633
confusion 631
deep vein thrombosis 630
suicide 624
asthma 615
more...
Symptom
pain 261466
analgesia 14242
anesthesia 10421
headache 10057
discomfort 5569
discomfort 5315
fatigue 4991
low back pain 4304
nausea 3806
back pain 3796
weakness 3572
vomiting 3117
abdominal pain 3033
acute pain 2978
cancer pain 2630
numbness 1862
paresthesia 1686
diarrhea 1642
dyspnea 1598
nausea and vomiting 1553
constipation 1520
arthralgia 1477
neck pain 1472
chest pain 1461
myalgia 1409
erythema 1395
Neuropathic pain 1349
angina 1247
pelvic pain 1244
cough 1197
shoulder pain 1148
seizures 1092
knee pain 1086
facial pain 1014
neuralgia 919
sleepiness 914
spasticity 912
dizziness 900
Postoperative pain 862
insomnia 813
bone pain 809
distraction 801
leg pain 794
anorexia 793
collapse 792
spasm 782
functional recovery 680
agitation 676
orofacial pain 668
sciatica 621
dental pain 597
hip pain 575
tingling 511
dystonia 498
tremor 488
paresis 463
chronic back pain 440
Ill 422
photophobia 409
dysesthesia 384
dysuria 372
ataxia 361
breakthrough pain 355
colic 353
limb pain 338
tinnitus 325
bloating 312
vertigo 295
hypothermia 290
wrist pain 288
overweight 287
chills 284
groin pain 280
epigastric pain 273
shortness of breath 272
sore throat 260
Sedation 253
syncope 240
asthenia 239
heartburn 234
more...
Drug
Dermatol 1498
Cardiovasc 901
CSF 454
Gabapentin 358
Fentanyl 344
caffeine 334
nitroglycerin 317
Monit 255
Pregabalin 245
Bupivacaine 228
ENT 197
lysine 187
Propofol 173
Ketorolac 157
Indomethacin 155
Clonidine 144
MAP 137
Posture 137
Spectrum 137
Domperidone 130
Duloxetine 121
ascorbate 112
CTX 112
Nephron 104
Ranitidine 100
vitamin E 92
Leaf 91
BoNT/A 90
Dial 90
Histamine 89
9-THC 86
Oxaliplatin 86
IL-2 85
Codeine 83
Diclofenac sodium 83
Asthma 81
ampicillin 80
Xylocaine 80
Tapentadol 79
Codeine 78
THA 74
lactose 73
ICI 70
ROC 68
EE2 66
Norplant 65
Botox 64
Zoledronic acid 64
Voltaren 63
EHDP 62
SNL 62
CAM 61
Check 60
PTH 59
p75 58
ROS 57
Denosumab 56
FLP 56
Acyclovir 54
Ziconotide 54
Ketorolac tromethamine 53
Zoledronic acid 53
Gel 51
Portal 51
Xylocaine 51
Butorphanol 49
Xylocaine 48
IFN-gamma 47
G-CSF 46
Ethanol 46
CTX 45
CFS 44
CTX 44
Nimesulide 44
Prednisolone 43
Norplant 42
Triad 42
IL-1ra 41
Prednisone 41
Misoprostol 40
more...
Enzyme
mitogen-activated protein kinase 923
ERK 701
protein kinase 609
alkaline phosphatase 519
protein kinase C 515
creatine kinase 437
peroxidase 339
ACS 232
superoxide dismutase 223
catalase 208
focal adhesion kinase 204
alanine aminotransferase 190
aspartate aminotransferase 183
lactate dehydrogenase 183
botulinum neurotoxin 153
NO synthase 143
prostate-specific antigen 138
phospholipase C 134
tyrosine hydroxylase 131
trypsin 130
luciferase 127
collagenase 127
phosphodiesterase 121
lipase 114
thrombin 114
acetylcholinesterase 113
hyaluronidase 111
MEK 108
phospholipase A2 107
hyaluronidase 106
ACE 103
reverse transcriptase 102
ATPase 97
tissue plasminogen activator 95
MDP 94
CD10 92
caspase-3 92
calcineurin 90
guanylate cyclase 90
proteasome 88
lipoxygenase 87
alpha-galactosidase 83
renin 82
NOS 82
adenylate cyclase 74
kallikrein 73
monoacylglycerol lipase 73
thromboplastin 72
monoamine oxidase 72
glutathione peroxidase 70
urokinase-type plasminogen activator 68
CPT 67
cholinesterase 66
CYP3A4 64
prostaglandin synthetase 64
soluble epoxide hydrolase 63
CPT 62
CPT 62
MCS 60
APC 59
CaMKII 56
MAP 55
AST 55
acid phosphatase 52
CAD 51
CAD 51
CAD 51
P-glycoprotein 50
SCS 49
AMPK 47
caspase-1 47
tryptase 45
heme oxygenase 45
AMP-activated protein kinase 45
NADPH oxidase 44
NADPH oxidase 43
MIP 43
phosphatidylinositol 3-kinase 42
aldose reductase 42
PKG 40
more...
Compound
Clin 19856
Dec 17578
calcium 3373
water 2910
sodium 2737
oxygen 2525
glutamate 1578
glucose 1204
TNF 1190
Morphine 1173
nitric oxide 1127
acetic acid 1089
His 1084
5-HT 947
GABA 940
GABA 927
potassium 889
CO2 888
ASA 861
DNA 826
Cardiol 815
phosphate 802
ATP 790
ethanol 773
sulfate 747
NMDA 664
APAP 643
noradrenaline 639
acetate 608
creatinine 567
arginine 553
hyaluronic acid 465
titanium 442
tyrosine 409
Capsaicin 405
vitamin D 403
Lidocaine 386
Naloxone 372
tryptophan 360
PGE2 353
caffeine 346
copper 329
salt 326
Tramadol 322
iron 314
PGE 314
nitrogen 314
barium 313
hydrogen 312
Substance P 312
Phe 302
cAMP 296
gamma-aminobutyric acid 290
Ketamine 289
formaldehyde 283
lysine 282
Optimal 279
DSM 266
urea 264
silver 263
AMPA 249
Gly 249
T10 248
methionine 240
phenol 235
ACS 234
ACS 232
glycerol 229
Buprenorphine 222
iodine 222
N2O 221
HCl 221
Ibuprofen 219
Bupivacaine 219
zinc 218
galactose 217
Neuronal 212
cysteine 211
serine 210
Calcitonin 205
more...