Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.11 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 16176
MRI 3345
She 3284
Mol 3255
opioid receptor 1966
substance P 1787
cytokine 1409
calcitonin 1366
TNF 1190
TRPV1 981
collagen 926
axonal 924
GABA 919
tumor necrosis factor 907
IL-6 874
COX-2 849
Hip 823
insulin 798
NMDA receptor 785
ATP 783
gut 780
bradykinin 767
beta-endorphin 740
cyclooxygenase 734
C-reactive protein 719
Pol 704
hemoglobin 696
reserved 670
nerve growth factor 656
ASA 594
ankylosing spondylitis 578
cyclooxygenase-2 555
CO2 524
alkaline phosphatase 519
ANOVA 518
transient receptor potential vanilloid 1 506
sodium channel 500
calcium channel 463
lipopolysaccharide 457
cage 457
brain-derived neurotrophic factor 448
DRG 443
P2X 431
Mot 424
p38 422
TRPA1 415
CSF 413
glial fibrillary acidic protein 413
Gen 409
interleukin-6 404
CB1 374
fused 360
COX-1 358
IL-10 353
nitric oxide synthase 352
cannabinoid receptor 339
5-hydroxytryptamine 333
CB2 329
cholecystokinin 326
short form 325
chemokine 324
creatine kinase 323
dynorphin 320
Mal 317
oxytocin 316
somatostatin 314
c-fos 304
osteosarcoma 291
CGRP 286
inducible nitric oxide synthase 282
CRP 275
ERK 274
PCA 268
ESR 268
P2X3 260
T12 259
MAPK 258
OFQ 257
IL-1 254
T10 248
albumin 244
C30 243
interferon 241
mast cell 239
Men 238
SNS 238
olfactory 236
extracellular signal-regulated kinase 235
ACS 232
hole 231
ionotropic 228
CD4 226
TLR4 224
ERK1 222
NMR 222
sit 221
mu opioid receptor 218
LPS 214
amylase 209
Nav1.7 206
Calcitonin 205
FDG 204
ACTH 201
myeloperoxidase 198
TNF-alpha 198
voltage-gated sodium channel 194
prolactin 194
NR2B 194
metabotropic glutamate receptor 192
TRP 190
PKC 186
vascular endothelial growth factor 184
ankyrin 1 184
galanin 184
proton pump 183
superoxide dismutase 183
COX 181
glutamate receptor 180
San 180
IL-8 179
fatty acid amide hydrolase 178
vasopressin 176
tumor necrosis factor alpha 175
ROM 175
fibrinogen 172
nicotinic acetylcholine receptor 172
TRPM8 171
neurotrophin 171
neuropeptide Y 170
parathyroid hormone 168
tyrosine kinase 167
ENT 165
cytochrome P450 163
Pseudomonas 163
Mil 163
glucosamine 161
growth hormone 161
NGF 161
TMD 160
lactate dehydrogenase 160
SII 159
polypeptide 158
CFA 158
anonymous 157
ICD 157
JAMA 156
asymmetrical 156
lymphoid 155
estrogen receptor 155
aromatase 154
G protein-coupled receptor 154
X-linked 152
HT3 151
rheumatoid factor 149
T11 148
P2X7 148
lamp 147
NK1 147
Rec 146
prostate-specific antigen 145
more...
Disease
chronic pain 14578
cancer 13058
depression 9782
tumor 7664
osteoarthritis 7193
arthritis 4530
cold 4267
migraine 4149
rheumatoid arthritis 3888
diabetes 3351
fibromyalgia 2963
metastases 2896
neuropathy 2682
pruritus 2566
ischemia 2131
hypertension 2106
carcinoma 1844
arthrodesis 1782
stroke 1757
breast cancer 1757
addiction 1589
osteoporosis 1558
Frey 1508
arthropathy 1493
peripheral neuropathy 1449
trigeminal neuralgia 1395
endometriosis 1354
obesity 1229
irritable bowel syndrome 1227
HIV 1191
epilepsy 1156
myocardial infarction 1149
multiple sclerosis 1143
bone metastases 1125
hernia 1122
sickle cell disease 1063
postherpetic neuralgia 1049
chronic pancreatitis 1016
prostate cancer 1010
dysphagia 991
sepsis 964
diabetic neuropathy 961
anemia 921
Parkinson's disease 890
synovitis 881
sepsis 870
AIDS 866
herpes zoster 856
claudication 851
osteomyelitis 851
radiculopathy 845
pancreatitis 839
regional pain syndrome 816
psychological distress 802
uterus 800
dysplasia 799
cognitive impairment 791
rash 785
adenocarcinoma 773
dementia 767
carpal tunnel syndrome 699
myelopathy 670
tuberculosis 670
lung cancer 669
ankylosing spondylitis 666
acute myocardial infarction 660
infertility 654
Best 654
chronic disease 648
incontinence 646
infectious diseases 646
Alzheimer's disease 642
scoliosis 637
myocardial ischemia 634
gangrene 634
sleep disturbances 633
confusion 631
deep vein thrombosis 630
suicide 624
asthma 615
emotional distress 604
multiple myeloma 602
coronary artery disease 599
reflex sympathetic dystrophy 598
posttraumatic stress disorder 588
prolapse 587
polyneuropathy 574
abortion 568
delirium 568
lymphoma 551
gallstones 550
intermittent claudication 544
pneumonia 544
mental illness 532
heart failure 525
renal failure 517
spinal cord compression 512
dyspepsia 511
compartment syndrome 510
schizophrenia 509
West 503
major depressive disorder 501
pancreatic cancer 496
aggression 495
osteoarthritis of the knee 487
bowel obstruction 486
tendinitis 483
inguinal hernia 482
squamous cell carcinoma 479
spinal stenosis 473
TMJ 471
neuroma 469
sarcoma 468
vasculitis 462
systemic lupus erythematosus 452
bone disease 451
Anterior 449
osteoma 441
pneumothorax 435
appendicitis 434
rare disease 432
gastroesophageal reflux disease 431
phantom limb pain 429
renal disease 425
incontinence 424
pathological fracture 421
melanoma 421
plaque 418
spondylolisthesis 417
inflammatory bowel disease 417
interstitial cystitis 417
celiac disease 416
anxiety disorders 415
diplopia 413
acute pancreatitis 410
paraplegia 405
bursitis 404
immunodeficiency 401
sleep disorders 400
varicella 398
pulmonary embolism 395
varices 389
Infection 387
lymphadenopathy 386
sexual dysfunction 385
ureter 385
atherosclerosis 384
cardiovascular disease 383
duodenal ulcer 380
drug abuse 375
proptosis 374
hemangioma 371
gout 371
cerebral palsy 370
hypercalcemia 370
fits 365
xerostomia 365
peritonitis 365
Complex regional pain syndrome 363
glaucoma 360
more...
Symptom
pain 261466
analgesia 14242
anesthesia 10421
headache 10057
discomfort 5569
discomfort 5315
fatigue 4991
low back pain 4304
nausea 3806
back pain 3796
weakness 3572
vomiting 3117
abdominal pain 3033
acute pain 2978
cancer pain 2630
numbness 1862
paresthesia 1686
diarrhea 1642
dyspnea 1598
nausea and vomiting 1553
constipation 1520
arthralgia 1477
neck pain 1472
chest pain 1461
myalgia 1409
erythema 1395
Neuropathic pain 1349
angina 1247
pelvic pain 1244
cough 1197
shoulder pain 1148
seizures 1092
knee pain 1086
facial pain 1014
neuralgia 919
sleepiness 914
spasticity 912
dizziness 900
Postoperative pain 862
insomnia 813
bone pain 809
distraction 801
leg pain 794
anorexia 793
collapse 792
spasm 782
functional recovery 680
agitation 676
orofacial pain 668
sciatica 621
dental pain 597
hip pain 575
tingling 511
dystonia 498
tremor 488
paresis 463
chronic back pain 440
Ill 422
photophobia 409
dysesthesia 384
dysuria 372
ataxia 361
breakthrough pain 355
colic 353
limb pain 338
tinnitus 325
bloating 312
vertigo 295
hypothermia 290
wrist pain 288
overweight 287
chills 284
groin pain 280
epigastric pain 273
shortness of breath 272
sore throat 260
Sedation 253
syncope 240
asthenia 239
heartburn 234
paraparesis 229
blurred vision 224
joint stiffness 219
hyperesthesia 218
exhaustion 214
Wind 212
flank pain 210
arm pain 209
abdominal discomfort 206
heel pain 206
otalgia 202
renal colic 202
acute abdomen 199
respiratory distress 198
lethargy 194
stigma 192
urinary frequency 184
acute abdominal pain 182
cachexia 182
splenomegaly 181
pallor 180
thigh pain 178
ophthalmoplegia 174
ankle pain 171
thinning 170
hoarseness 168
ENT 166
bladder pain 162
hepatomegaly 162
hemoptysis 161
acute low back pain 158
apathy 153
swollen joints 150
flushing 149
cyanosis 149
dry eye 144
metatarsalgia 143
hunger 142
hopelessness 139
torticollis 139
Chronic pelvic pain 137
regurgitation 134
body pain 131
myoclonus 129
mastalgia 125
acute stress 123
elbow pain 121
generalized pain 120
rhinorrhea 116
hemiplegia 111
hand pain 106
snoring 105
alexithymia 103
stump pain 103
Severe pain 103
tense 102
Visceral pain 101
skin irritation 98
muscle cramps 95
testicular pain 93
hypercapnia 92
hot flashes 90
Tenderness 89
tenesmus 87
Depressive symptoms 84
muscle stiffness 84
despair 84
decreased appetite 83
jaw pain 80
abnormal gait 80
neck stiffness 79
acidity 77
dysarthria 76
hypalgesia 76
night sweats 76
eye pain 76
stomach pain 75
tachypnea 75
hypertonia 74
hypotonia 74
more...
Drug
Dermatol 1498
Cardiovasc 901
CSF 454
Gabapentin 358
Fentanyl 344
caffeine 334
nitroglycerin 317
Monit 255
Pregabalin 245
Bupivacaine 228
ENT 197
lysine 187
Propofol 173
Ketorolac 157
Indomethacin 155
Clonidine 144
Spectrum 137
MAP 137
Posture 137
Domperidone 130
Duloxetine 121
ascorbate 112
CTX 112
Nephron 104
Ranitidine 100
vitamin E 92
Leaf 91
Dial 90
BoNT/A 90
Histamine 89
Oxaliplatin 86
9-THC 86
IL-2 85
Codeine 83
Diclofenac sodium 83
Asthma 81
ampicillin 80
Xylocaine 80
Tapentadol 79
Codeine 78
THA 74
lactose 73
ICI 70
ROC 68
EE2 66
Norplant 65
Zoledronic acid 64
Botox 64
Voltaren 63
SNL 62
EHDP 62
CAM 61
Check 60
PTH 59
p75 58
ROS 57
Denosumab 56
FLP 56
Acyclovir 54
Ziconotide 54
Zoledronic acid 53
Ketorolac tromethamine 53
Portal 51
Xylocaine 51
Gel 51
Butorphanol 49
Xylocaine 48
IFN-gamma 47
G-CSF 46
Ethanol 46
CTX 45
CFS 44
Nimesulide 44
CTX 44
Prednisolone 43
Norplant 42
Triad 42
Prednisone 41
IL-1ra 41
ABC 40
Misoprostol 40
Adriamycin 40
Methylprednisolone 39
Cimetidine 39
TMS 39
Almotriptan 38
Morphine sulfate 38
citric acid 37
Rizatriptan 37
DHT 36
DHT 36
Dakar 35
Atropine 35
Metrizamide 34
Tramal 34
Scopolamine 34
PCP 33
CPM 33
Dipyrone 33
Clodronate 32
Taxol 32
Omeprazole 32
Iohexol 32
Spectrum 32
Cimetidine 31
Nitric Oxide 31
Bortezomib 31
Gelfoam 31
Etodolac 31
Arthrex 30
Nephron 30
Diphenhydramine 30
BOTOX 30
Gastro 30
Marcaine 29
Levonorgestrel 29
Alliance 28
Cilostazol 28
MRC 28
Docetaxel 28
Tenoxicam 28
Menthol 28
Triad 28
Vioxx 27
Parecoxib 27
ADM 27
Capsicum 27
Bayer 27
HCG 26
BH4 26
EPI 26
Ringer's solution 25
ACT 25
Vitamin E 25
TAC 25
Frontal 25
EPA 24
Estrogens 24
CDP 24
Valdecoxib 24
Streptokinase 23
Opium 23
Fluorescein 23
Emodin 23
Meconium 22
MgSO4 22
Iloprost 22
DBS 21
TAT 21
ALA 21
Asn 21
Subutex 21
Vicryl 21
APD 21
Lornoxicam 21
Ginger 21
Kenyan 21
Indocid 21
OTC 20
Almotriptan 20
more...
Enzyme
mitogen-activated protein kinase 923
ERK 701
protein kinase 609
alkaline phosphatase 519
protein kinase C 515
creatine kinase 437
peroxidase 339
ACS 232
superoxide dismutase 223
catalase 208
focal adhesion kinase 204
alanine aminotransferase 190
aspartate aminotransferase 183
lactate dehydrogenase 183
botulinum neurotoxin 153
NO synthase 143
prostate-specific antigen 138
phospholipase C 134
tyrosine hydroxylase 131
trypsin 130
collagenase 127
luciferase 127
phosphodiesterase 121
thrombin 114
lipase 114
acetylcholinesterase 113
hyaluronidase 111
MEK 108
phospholipase A2 107
hyaluronidase 106
ACE 103
reverse transcriptase 102
ATPase 97
tissue plasminogen activator 95
MDP 94
CD10 92
caspase-3 92
calcineurin 90
guanylate cyclase 90
proteasome 88
lipoxygenase 87
alpha-galactosidase 83
NOS 82
renin 82
adenylate cyclase 74
monoacylglycerol lipase 73
kallikrein 73
thromboplastin 72
monoamine oxidase 72
glutathione peroxidase 70
urokinase-type plasminogen activator 68
CPT 67
cholinesterase 66
CYP3A4 64
prostaglandin synthetase 64
soluble epoxide hydrolase 63
CPT 62
CPT 62
MCS 60
APC 59
CaMKII 56
MAP 55
AST 55
acid phosphatase 52
CAD 51
CAD 51
CAD 51
P-glycoprotein 50
SCS 49
AMPK 47
caspase-1 47
tryptase 45
heme oxygenase 45
AMP-activated protein kinase 45
NADPH oxidase 44
MIP 43
NADPH oxidase 43
phosphatidylinositol 3-kinase 42
aldose reductase 42
PKG 40
MMP-3 40
NADPH-diaphorase 39
carbonic anhydrase 37
chymopapain 37
chymopapain 37
GSK 36
adenosine kinase 36
PARP 36
CPM 33
tryptophan hydroxylase 33
PCP 33
elastase 31
NQO1 31
lipoprotein lipase 31
phosphoinositide 3-kinase 30
AOR 29
CD13 29
lysozyme 28
RNA polymerase 28
xanthine oxidase 28
FPS 28
BMT 27
prostate-specific membrane antigen 27
adenosine deaminase 26
GRK5 26
glutathione S-transferase 26
beta-lactamase 26
adenosine deaminase 26
plasmin 26
AMPK 25
chymotrypsin 25
gamma-glutamyl transpeptidase 25
pepsin 24
PRE 24
papain 24
dopamine beta-hydroxylase 23
BIS 23
bromelain 23
deaminase 22
DNA methyltransferase 21
choline acetyltransferase 21
TAT 21
transcriptase 21
SST 20
glutamate decarboxylase 20
IKK 20
PTA 20
ceruloplasmin 20
ornithine transcarbamylase 19
diaphorase 19
diaphorase 19
glutamine synthetase 19
alpha-amylase 19
cathepsin K 19
RNase 19
RNase 19
aldehyde dehydrogenase 18
aldolase 18
GTP cyclohydrolase I 17
UDP-glucuronosyltransferase 17
MMP 17
enolase 16
alcohol dehydrogenase 16
CPN 16
TACE 16
cathepsin S 15
thyroid peroxidase 15
urease 15
urease 15
DAT 14
CFI 14
lactase 14
arginase 14
ADH 14
neutrophil elastase 14
CPR 14
furin 13
serine racemase 13
tissue kallikrein 13
STR 13
more...
Compound
Clin 19856
Dec 17578
calcium 3373
water 2910
sodium 2737
oxygen 2525
glutamate 1578
glucose 1204
TNF 1190
Morphine 1173
nitric oxide 1127
acetic acid 1089
His 1084
5-HT 947
GABA 940
GABA 927
potassium 889
CO2 888
ASA 861
DNA 826
Cardiol 815
phosphate 802
ATP 790
ethanol 773
sulfate 747
NMDA 664
APAP 643
noradrenaline 639
acetate 608
creatinine 567
arginine 553
hyaluronic acid 465
titanium 442
tyrosine 409
Capsaicin 405
vitamin D 403
Lidocaine 386
Naloxone 372
tryptophan 360
PGE2 353
caffeine 346
copper 329
salt 326
Tramadol 322
nitrogen 314
iron 314
PGE 314
barium 313
Substance P 312
hydrogen 312
Phe 302
cAMP 296
gamma-aminobutyric acid 290
Ketamine 289
formaldehyde 283
lysine 282
Optimal 279
DSM 266
urea 264
silver 263
AMPA 249
Gly 249
T10 248
methionine 240
phenol 235
ACS 234
ACS 232
glycerol 229
Buprenorphine 222
iodine 222
N2O 221
HCl 221
Ibuprofen 219
Bupivacaine 219
zinc 218
galactose 217
Neuronal 212
cysteine 211
serine 210
Calcitonin 205
leucine 203
ACTH 201
prostacyclin 196
threonine 189
6-12 188
Propofol 186
strontium 186
prostaglandin E1 185
acetone 184
Pac 183
COX 181
alanine 180
A 42 180
cobalt 179
nitrate 177
Methadone 174
aluminum 168
Diclofenac 167
methanol 166
tryptophan 165
Glutamate 164
DAMGO 161
tryptophan 160
tryptophan 160
PEG 159
cGMP 158
Bradykinin 153
Indomethacin 150
NH2 150
T11 148
nicotinamide 143
AMP 143
bromide 143
Ketorolac 141
Diazepam 140
phosphorus 136
A 3 135
Isoproterenol 134
hydroxide 134
Neurotol 132
Adrenal 131
salicylic acid 128
Estrogen 127
Oxycodone 126
DMSO 119
Adenosine 119
GSH 118
GSH 118
fluorine 117
Sodium 114
A 71 114
Meperidine 113
Paclitaxel 112
CTX 112
5-FU 109
Celecoxib 109
Estrogen 109
aspartic acid 109
THE 108
Dexmedetomidine 105
sodium chloride 104
CAM 103
ADP 102
HAQ 100
AEA 100
Dexamethasone 96
Dial 95
Remifentanil 94
pyridine 94
MTT 93
Midazolam 93
propionic acid 93
propionic acid 93
Parenteral 93
PEG 92
Cortisol 92
ethyl acetate 92
MAP 92
Amitriptyline 92
Cereb 91
more...