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Query: UMLS:C0030193 (
pain
)
261,466
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The leaves of
Salvia officinalis L
. have a traditional reputation for the management of
pain
in Morocco. This study was conducted to investigate the curative effects of
Salvia officinalis
(SO) and its major constituents Rosmarinic (ROS) and Caffeic acids (CAF) on peripheral neuropathic
pain
in mice. Chronic constriction injury (CCI) was induced in mice, and neuropathic
pain
behaviors tests were evaluated by mechanical, chemical, thermal sensation tests and functional recovery of the sciatic nerve at different time intervals,
i.e
., (day 0, 1, 7, 14, and 21). Ethanolic extract of SO (100 and 200 mg/kg,
p.o.
), ROS (10 and 20 mg/kg,
i.p.
), CAF (30 and 40 mg/kg,
i.p.
), and
CLOM
(5 mg/kg,
i.p.
, a positive control) was given for 21 days after surgery. Hematological and biochemical parameters were also measured as well as histopathological analysis. CCI produced significant development in mechanical and thermal hyperalgesia, cold allodynia, and rise in the sciatic functional index in mice. Chronic treatments with SO extract, ROS, CAF, and
CLOM
for 3 weeks significantly increased mechanical sensibility, cold, and thermal withdrawal latency and enhanced functional recovery of the injured nerve. The same treatments remarkably ameliorated hematological parameters and did not alter biochemical levels. The histopathological findings had revealed the protective effect of SO, ROS, and CAF against the CCI-induced damage. Our data support the use of SO in folk medicine to alleviate
pain
. Their main phenolic constituents could be promising antineuropathic compounds, which may be attributed to their biological activities including anti-inflammatory, antioxidant, and neuroprotective effects. SO leaves may be a good candidate to treat neuropathic
pain
.
...
PMID:
Salvia officinalis
, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. 3134 89
