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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The studied material comprised 15 men with 12 of them having the episodic from of Horton's headaches and 3 with chronic form. In the episodic form the age of the patients was from 32 to 48 years, mean age 38. The history of the disease was from 6 to 12 years, the duration of a spell of headaches was 2-3 months and the patients had then 2-5 attacks of pain daily. Before the onset of treatment the patients were not given for 1 week any drugs or placebo. After determination of the index of attacks treatment was begun. For 7-10 days the patients received daily intramuscular testosterone propionate 25 mg, and then 10 mg for a similar time period. Before the treatment the index of attacks was 3.66 (with the total number of attacks 308). In the first week of treatment it decreased to 1.11 (94 attacks), in the second week it was 0.16 and in the third week 0.05. In 10 patients the attacks disappeared completely (83%), in the remaining 2 ones they regressed in a later time. Three patients with the chronic form received this treatment without effect.
Neurol Neurochir Pol
PMID:[Treatment of Horton's headache with testosterone]. 383 88

The lesions of medial habenular nuclei increased the pain sensitivity, enhanced the analgesic activity of morphine and slightly activated the behavior. The lesion of fasciculus retroflexus, a pathway connecting habenular nuclei with interpeduncular nucleus enhanced the pain sensitivity less markedly, did not change the efficacy of morphine analgesia, but significantly increased the activity of animals. The lesion of interpeduncular nucleus influenced the pain sensitivity to a smallest degree, did not change the analgesic activity of morphine, but dramatically increased the activity of animals. The activation did not resemble the aimless excitation of amphetamine-treated or raphe-lesioned rats, and no signs of increased emotionality or irritability were noted. The results are interpreted as an evidence of habenulo-interpenduncular complex being a part of a system, involved in the regulation of behavioral activity and the sensitivity to the aversive stimuli. These functions are in all probability mediated partly through substance P and met-enkephalin containing neurons, present in these structures.
Pol J Pharmacol Pharm
PMID:Habenulo-interpeduncular lesions: the effects on pain sensitivity, morphine analgesia and open-field behavior in rats. 390 26

From a series of 110 cases of surgically treated trigeminal neuralgia the author reports two cases in which impressio basilaris was the cause of neuralgia. One of these patients was operated on by the method of Frazier-Spiller, the other by Dandy's method in a microsurgical modification. These two methods gave the author an opportunity of comparing intraoperative findings in the middle and posterior cranial fossa. In the middle cranial fossa besides deformity of the base of the skull thinning was found of the dura, flattening of Gasser's ganglion and the postganglionic fibres of the trigeminal nerve were taut on the edge of the pyramid. In the posterior fossa the pontocerebellar angle was crowded despite removal of some cerebrospinal fluid. The postganglionic fibres of the trigeminal nerve were closely adherent to the pons and were visible on a small distance from the tentorium to the pons. In both cases postganglionic rhizotomy was done and the patients were relieved from pain.
Neurol Neurochir Pol
PMID:[Causative relationship between cranial base deformities and trigeminal neuralgia]. 409 46

Glomangiomas are most frequently situated on fingers and toes, especially in the vicinity of the ungual plate. The authors report five cases of glomangiomas of atypical location/in the knee joint, in the vicinity of femoral and tibial epiphyses, and in the subcutaneous tissue on the forearm. The clinical findings are described, stressing the lack of parallelism between the intensity of symptoms and the size of the tumour which rarely exceeds the size of a millet grain. Complete removal of the tumour produces complete disappearance of pain and recurrences are not observed.
Neurol Neurochir Pol
PMID:[Glomangiomas of atypical location]. 609 47

The authors present the results of determinations of beta-endorphin-like immunoreactivity in the plasma carried out before and after pinpoint receptor stimulation (prs) that is acupuncture in patients with long-standing pain. No significant differences were observed in this immunoreactivity after prs, and the clinical analgesic effect was independent of the level of this immunoreactivity and its changes during these procedures. On the other hand, a positive correlation was demonstrated between plasma beta-endorphin concentration and the neuroticism index as evaluated by Eysenck's personality inventory. The reliability of this observation requires, however, confirmation in a greater material.
Neurol Neurochir Pol
PMID:[Beta endorphin-like immunoreactivity in the blood of patients with chronic pain treated by pinpoint receptor stimulation (acupuncture)]. 609 39

The effects of benzodiazepine (mainly diazepam) on the following central action of narcotic analgesics were tested: antinociceptive action (Randall-Selitto and hot plate tests), hypermotility, inhibition of methylphenidate stereotypy, catalepsy. Diazepam, in doses not affecting the pain threshold markedly potentiated morphine, codeine, etorphine, pentazocine and fentanyl antinociception. Hypermotility produced by morphine and fentanyl was inhibited by pretreatment with chlordiazepoxide, diazepam and clonazepam. Diazepam potentiated the inhibitory effect of opiates on methylphenidate-induced stereotyped gnawing in mice and increased the catalepsy induced by morphine and fentanyl in rats. In all experiments the effects of diazepam were suppressed by the substances which impair GABA-ergic neurotransmission: bicuculline and picrotoxin. Obtained results indicate that benzodiazepine potentiate the antinociceptive and cataleptogenic effects of opiates and their inhibitory influence on methylphenidate stereotypy. However, these drugs antagonize locomotor hyperactivity in mice. All these actions seem to be related to facilitation of GABA-ergic neurotransmission by benzodiazepines.
Pol J Pharmacol Pharm 1982
PMID:Effect of benzodiazepines on the central action of narcotic analgesics. 613 69

The authors describe two cases of congenital indifference to pain in a man aged 34 years and a woman aged 23 years. The clinical manifestations in both cases fulfilled the criteria for the diagnosis of these disturbances.
Neurol Neurochir Pol
PMID:[2 cases of congenital analgesia]. 619 84

After a review of the modern views on the problem of the so called Tarlov's cysts the authors present a group of 20 patients with chronic low back pains in whom periradicular cysts were diagnosed demonstrating them by means of Dimer-X radiculography. In the light of an analysis of this material the authors reach the conclusion that there are no specific symptoms and signs which could make possible the diagnosis of Tarlov's cysts without contrast radiography of the dural sac. There are, moreover, no reliable data demonstrating that the clinical manifestations in patients with Tarlov's cysts are indeed caused by them since surgical verification demonstrates often other causes of pain.
Neurol Neurochir Pol
PMID:[Clinico-radiological picture of periradicular cysts in the lumbosacral region]. 623 73

A Polish version of pain questionnaire for pain intensity definition has been prepared after an inquiry study on the "pain glossary" which showed that in the Polish language a large number of words are used for characterization of pain. These words contain information about pain intensity understandable for the studied population. The authors describe this questionnaire and discuss a preliminary evaluation of its usefulness for assessing the effectiveness of pain management. The presented questionnaire makes possible evaluation of pain intensity in several indices whose values correlate significantly with each other. In comparative investigations a significant correlation has been found also between the indices of pain intensity in the questionnaire and the index in the 24-hour observation card. The mean differences of pain intensity scores calculated before and after the treatment differed significantly in definite categories of verbal evaluation of treatment effectiveness. This justifies the conclusion that the questionnaire may be useful for evaluating treatment effectiveness by a method not depending on the utterances of the patients.
Neurol Neurochir Pol
PMID:[Questionnaire method of evaluating the effectiveness of the treatment of pain]. 624 Dec 98

Three types of muscular reaction to pain were distinguished. Type I--a defensive reaction to a noxious stimulus, type II--muscular guarding at the site of pain, type III--suffering expression. The third type includes reaction of facial muscles discernible only at high pain intensity in subjects with hypersensitivity to pain. In a search for this reaction in all pains electromyographic investigations of the mentalis muscle were carried out since their connection with nociceptive stimulation is made use of in the sign of Marinesco-Radovici. In 18 out of 20 patients with sciatic pain spontaneous activity was observed in the mentalis muscle. Intensification of pain caused by nerve stretching (straight-leg-raising test) evoked activity of these muscles in all studied patients and its intensity was higher. The observed reaction may be an objective evidence of suffering.
Neurol Neurochir Pol
PMID:[Electromyographic study of mentalis muscle reaction to pain]. 625 91


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