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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effect of lesion of the dorsal raphe nucleus (DRN) or median raphe nucleus (MRN) on the locomotor activity, open field performance, and reactivity to noxious stimulus was tested in rats. During the first 7 days after the lesion, the rats with lesioned DRN showed higher basal and explorative locomotor activity than the rats with MRN lesions. The lesion of DRN increased the open-field performance and reactivity to pain. The results of tests carried out on the rats with MRN lesions were similar as in control rats. The results indicate that the different behavioral effect of lesions of DRN and MRN reffects differences in the functions of these two raphe nuclei.
Pol J Pharmacol Pharm
PMID:The effect of lesions of dorsal or median raphe nucleus on rat behavior. 60 Aug 58

The authors report the results of treatment with a modification of acupuncture associated with chemical stimulation in 144 patients with painful radicular syndromes and headaches. In 57 cases sciatic pains were present, in 21 cases shoulder pains, in 20 migraine and in 46 vasomotor headaches. Permanent disappearance of pain, that is disappearance of pain during the procedure and lack of recurrence within several successive days, was obtained in about 40% of cases of radicular syndromes and in 62% of cases of headaches, early disappearance of pain for 3 to 48 hours after the procedure was obtained in 14% of radicular syndromes and nearly 26% headaches, while improvement, that is reduction of pain intensity, was achieved in 29.5% of radicular pains and 3% of headaches, while in 15.3% of cases of radicular syndromes and 9% of cases of headaches no improvement was observed. Both vasomotor headaches and neuralgias belong to the group of nervous system diseases in which pain is the basic and sole symptom, while treatment includes its removal. In these cases acupuncture is a valuable analgesic method. The presently reported results agree with those in the literature on the use of classical acupuncture and its modifications. It is worth stressing that insertion of needles into the traditional points used in classical acupuncture is without any greater importance was shown by the presently reported experiences (various points were used in the same case) as well as by the reports of other authors. The modification of acupuncture with addition of chemical stimulation has been tried by the authors for 4 years. A weak stimulus resulting from insertion of the needle and irritation of the nerve endings with concentrated sodium chloride acts similarly as mechanical or electrical irritation. The method is simple and completely safe.
Neurol Neurochir Pol
PMID:[Modified acupuncture in the treatment of pain]. 68 27

In 50 patients with headaches and 50 with radicular pains pain sensitivity and pain tolerance as well as personality traits (Eysenck and Cattell questionnaire) were determined and a modification of acupuncture (with additional chemical stimulation) was used for treatment. The results of treatment were compared with personality traits. Differences were found in the personality traits between patients with paroxysmal headaches and patients with radicular pains. No statistically significant correlation was found, on the other hand, between the results of treatment and personality traits. The obtained results were best in the group of patients with paroxysmal headaches (permanent analgesic effect obtained in 70% of cases). The results of treatment obtained in the group of patients with continuous headaches and with radicular pains were similar. In patients with a lower threshold of pain sensitivity a higher proportion of permanent disappearance of pain was observed after treatment, and this observation may be useful for establishing indications to this therapy. Lack of any influence of personality traits on the result of this modified acupuncture may suggest that the basic analgesic action of these procedure is at lower levels of the nervous system and that it causes blockade of inflow of pain stimuli.
Neurol Neurochir Pol
PMID:[Type of pain, personality traits and effectiveness of modified acupuncture]. 68 28

The authors determined the subjective, objective and maximal pain threshold by means of electrical stimulation in two groups of subjects. Group I comprised healthy subjects, group II patients with right-sided radicular cervicobrachial pains. The method applied by the authors for objective determination of pain threshold with evoked cortical somatosensory potential differentiated both groups which suggests its practical usefulness in clinical practice and expertise.
Neurol Neurochir Pol
PMID:[Evoked cortical somatosensory potentials in painful cervicobrachial radicular syndromes]. 68 29

The author describes a 47-year-old patient in whom lingual hemiatrophy developed one month after angina. The development of hemiatrophy was preceded by occipital headaches and pain behind the ear on the side of hemiatrophy. In the differential diagnosis the author excluded inflammatory processes neoplasms and developmental anomalies and thinks that the cause of this short-lasting hemiatrophy might have been tonsillitis with compression of the nerve by the oedematous inflamed tissues with action of bacterial toxins on the nerve.
Neurol Neurochir Pol
PMID:[Short-lived semi-atrophy of the tongue]. 71 30

Analgesic activity of pethidine and pentazocine in the locus coeruleus lesioned rats was evaluated. Bilateral destruction of locus coeruleus resulted in a marked decrease in noradrenaline content in forebrain but did not change significantly the levels of dopamine. Lesioned animals showed a marked decrease of predrug pain threshold. However, pethidine increased more effectively the nociceptive threshold in lesioned rats. The effect observed after pentazocine was generally similar but the maximal increase in pain threshold in lesioned animals did not differ significantly from the values observed in sham lesioned rats. The action of both analgesics was markedly prolonged after the lesion of the locus coeruleus.
Pol J Pharmacol Pharm
PMID:Lesion of locus coeruleus: the effect on pethidine and pentazocine analgesia. 75 43

The effects of three-day treatment with meclophenoxate (Centrophenoxin) and its components, p-chlorophenoxyacetic acid and dimethylaminoethanol, on the aggressiveness and pain threshold in mice were investigated. p-Chlorophenoxyacetic acid increased the aggressiveness and pain sensitivity. Dimethylaminoethanol, on the contrary, tended to decrease these items of behaviour. The effects of meclophenoxate reflected this reciprocal activity of components, the activity of p-chlorophenoxyacetic acid prevailing. The results are taken as the evidence of some slowly developing mechanism in the activity of p-chlorophenoxyacetic acid, responsible for some of the effects of meclophenoxate. A possible mode of action of p-chlorophenoxyacetic acid is suggested.
Pol J Pharmacol Pharm 1976
PMID:Further study on pharmacology of meclophenoxate and it components in mice. 77 15

The authors reported their own experiences with prevention and treatment of pulmonary complications developing in burn disease. In burn shock the most important problem is maintenance of a sufficient volume of circulating blood and cardiac output, and effective control of pain resulting from thermal injury. Later, the most important becomes prevention of infections and early mobilization of patients. It was demonstrated that physiotherapy, air humidification, lung expansion and inhalations of broncholytic and mucolytic drugs prevented effectively pulmonary complications. When severe respiratory disturbances developed, controlled respiration was successfully applied in 9 cases.
Pol Med Sci Hist Bull
PMID:Respiratory disorders in severely burned patients. 82 94

A case of carotid-ophthalmic aneurysm of unusual location in the optic nerve is reported. The development of the disease was sudden: pain in the eye was followed by unilaternal blindness and manifestations of subarachnoid haemorrhage. The optic nerve was dilated balloon-like, cyanotic and vigorously pulsating. It was divided longitudinally and the aneurysmatic sac was exposed from the nerve. A vascular clip was put on its peduncle communicating with the cervico-ophthalmic portion of internal carotid artery. Despite preserved patency of the ophthalmic artery and partial continuity of the optic nerve, the vision of the eye didn't improve.
Neurol Neurochir Pol
PMID:[Aneurysm situated within the optic nerve]. 85 55

In 500 cases (379 men and 121 women) of ischemic heart disease, including 428 patients with myocardial infarction and 72 -- with imminent infarction, blood lipid levels were determined. Blood samples were taken on fasting, by the end of hospitalization, from patients with myocardial infarction on the 18th-21st day of disease, and from those with imminent infarction after cessation of pain. In 152 patients (30.4%), including 87 with infarction and 65 with imminent infarction, disturbances in the blood lipid pattern were found and classified according to Fredrickson. When expressed as percentage against the material of 152 patients with blood lipid disturbances, type II A was found in 103 cases (67.8%), type II B -- in 25 cases (16.4%), and type IV -- in 24 cases (15.8%). When calculated against the whole material of 500 patients, type II A accounted for 20.6%, type II B -- for 5%, and type IV -- 4.8% of cases.
Pol Med Sci Hist Bull
PMID:Hyperlipoproteinemia (acc. to Fredrickson's classification) in patients with myocardial infarction and imminent infarction. 95 45


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