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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The analgesic effect of morphine was studied by tail compression method in grouped and chronically isolated Wistar male rats developing muricide behavior showed increased pain threshold whilst indifferent (non-killer) showed reduced responses to the analgesic action of morphine. "Natural" killer (housed in groups) showed, on the other hand, increased sensitivity to morphine. The role of factors such as isolation period, behavioral pattern and contact with the victim was discussed.
Pol J Pharmacol Pharm
PMID:Factors which might modify analgesic effect of morphine in differentially housed rats. 1 53

The effect of alpha-adrenolytics: phenoxybenzamine, phentolamine, aceperone, dihydroegotamine, and yohimbine, was tested on reactivity to pain, and on the analgesic action of morphine and pethidine in albino mice. The compounds exert an analgesic effect by themselves, and potentiate the analgesic action of threshold doses of morphine and pethidine. The results seem to provide another proof that the cerbral noradrenaline neurons participate in central mechanisms of pain perception.
Pol J Pharmacol Pharm
PMID:Analgesic action of alpha-adrenolytics in albino mice. 1 52

Lesions of ventral tegmental area, localised in the region of A 10 group of dopaminergic mesolimbic neurons decreased the pain threshold in rats. The absolute threshold values in morphine treated animals with the above lesion were lower than in sham-operated controls, however, the thresholds expressed as percentage of predrug threshold values did not differ in both lesioned and sham-operated animals. It is thought, that lesions of ventral tegmental dopamine neurons decrease the pain threshold due to the increase of general excitability of animals, and that there is no direct involvement of the lesioned structure in the primary mechanism of morphine analgesia.
Pol J Pharmacol Pharm
PMID:The effects of lesion of mesolimbic dopamine neurons on pain threshold and morphine analgesia in rats. 2 47

In a group of 34 patients with lumbosacral pain acupuncture was applied in 18 cases and suggestion in 16 cases and the results of both methods were compared. The therapeutic effects were evaluated immediately after the procedure and after a series of 4 procedures. The therapeutic results were better both immediately and after a series of acupuncture. The difference in the results of treatment was statistically significant in the patients with longest duration of pains. Presence of degenerative spinal changes was without influence on the results of treatment by both methods.
Neurol Neurochir Pol
PMID:[Evaluation of the results of treatment of low backache by acupuncture or suggesting (preliminary report)]. 15 42

Two new compounds: 2- and 4-pyridylmethylamides of acetyltropic acid (PAT 2 and PAT-4) show spasmolytic effects on isolated guinea pig ileum, have mydriatic actevity in rabbits and block restraint produced ulceration in rats. PAT-4 causes a strong inhibition of the salivary secretion in mice. Both of the test compounds inhibit also the effects of ACh and vagus stimulation on the blood pressure and have local anaesthetic activity. PAT-4 inhibits the aggressive behaviour in mice and rats, prolongs the hexobarbital sleeping time, increases the pain treshold and inhibits the oxotremorine induced tremor in mice. Both PAT-2 and PAT-4 had no effect on the convulsant action of pentetrazole. EEG findings show that central cholinolytic activity is present in both compound tested.
Pol J Pharmacol Pharm
PMID:Pharmacological studies on 2- and 4-pyridylethylamides of acetyltropic acid (PAT-2 and PAT-4). 16 62

The authors observed 88 patients (18 women and 70 men) aged 16 to 61 years with lack of lumbar vertebral arch fusion (spina bifid occulta without spinal cord involvement). In 63 cases the clinical symptom complex was that of sciatic pains, in the remaining 25 cases no neurological defect was found. In 63 cases operation was done and 45 of them intervertebral disc prolapse was found. The decision to operate was based on the refractoriness and intensity of pain, presence of neurological defect and radiculography performed in 36 cases. It is stressed that such high proportion (51%) of cases with spina bifida coexistent with lumbar disc prolapse calls for a careful analysis of the cause of pain in patients with spina bifida.
Neurol Neurochir Pol
PMID:[Clinico-radiological correlation and treatment of patients with absence of lumbar vertebral arch fusion]. 37 20

In 6 patients the authors performed stereotaxic ventroposteromedial thalamotomy for abolition or reduction of pain. The operation produced lesions in the centrum medianum and parasfascicular nucleus. In 2 cases unilateral operation was performed contralaterally to the side of pain, in the remaining cases the operation was done bilaterally as a one-step procedure. Postoperative follow demonstrated that in 1 case improvement was completely absent, in 4 initial good effect was transient and pain returned after several weeks and in only 1 patient very good effect persists for over 12 months. In the light of these experiences and a survey of the pertinent literature the authors reach the conclusion that limited stereotatic lesion of the so called non-specific pain-transmitting thalamic nuclei produces permanent abolition or alleviation of pain in few cases only. The pathophysiology of pain is discussed in the light of these data.
Neurol Neurochir Pol
PMID:[Stereotaxic ventroposteromedial thalamotomy in the treatment. Clinical observations and physiopathological considerations]. 38 84

Albino-Swiss male mice were tested in the hot plate test. Oligomeric procyjanidin (OL-1), rutin, quercetin, hyperoside and vitexin rhamnoside were administered intraperitoneally in doses 3.5 and 10 mg/kg. It was found that OL-1, rutin and hyperoside but not vitexin rhamnoside exert analgesic action, whereas quercetin even decreases the pain threshold level. The mechanism of the analgesic action of flavonoids remains to be explained.
Acta Physiol Pol
PMID:The analgesic action of some flavonoids in the hot plate test. 49 43

Pain evoked potentials (EPs) were recorded in nucleus caudatus (NC) of rabbits after electric stimulation of the dental pulp. After 50--60 noxious stimuli the decrease in amplitude of evoked potentials occured. Naloxone, 1 mg/kg, temporarily abolished this effect and even after 350 noxious stimuli the habituation was not observed. On the other hand, naloxone did not affect the diminution of monosynaptic transcallosal potentials (TC--EP) evoked by repeated stimulation. It may be suggested that the habituation of EPs elicited by pain stimulation is due to endorphin release.
Pol J Pharmacol Pharm
PMID:Lack of habituation of pain evoked potentials after naloxone. 50 69

In the reported case unilateral external ophthalmoplegia developed in a young woman, with concomitant pain and anaesthesia in the area innervated by the 1st branch of the trigeminal nerve. After ruling out an expanding lesion of the central nervous system, aneurysm, diabetes, myasthenia, multiple sclerosis and other diseases dexamethasone was administered in a total dose of 30 mg. Complete clinical remission was achieved. In the light of observations and a survey of the peritinent literature it has been accumed that the disease was caused by a non-specific process in the small vessels in the vicinity of the cavernous sinus.
Neurol Neurochir Pol 1979
PMID:[Tolosa-Hunt syndrome (ophthalmoplegia dolorosa)]. 52 41


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