Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The follow-up of 42 patients with 50 symptomatic elbow joints [average age at operation: 66.1 years (46-79 years)] with rheumatoid arthritis at an average of 6.8 years (SD: 3.5 years) after joint-preserving open operation is presented in this study. Synovectomy was mandatory. Open synovectomy with facultative additional soft tissue techniques (AS) was performed on 17 elbows, while in 33 elbows joint surface remodeling (SR)-radial head excision included-was performed. There was only a slight progression in the overall Larsen staging from 3.70 to 4.02 in the operated joints, while the non-operated joints were nearly unchanged (3.43 vs 3.56). Especially in the SR group a nearly significant ( p=0.06) increase of 31.0 degrees for the total elbow ROM as a sum of extension/ flexion and pronation/supination could be detected, while the AS group slightly decreased with -1.1 degrees. Both groups gained a comparable average Morrey score result (AS 77.6 points vs SR 75.6 points). Poor results were not noticed at all. A mild collateral instability was seen in 40% of the AS and in 20% of the SR cases, respectively. Moderate instability was found in 10% in the AS vs 5% in the SR group. Both groups showed an excellent benefit in terms of pain relief, function, and satisfaction according to the patients' self-assessment on a visual analog scale.Joint-preserving operations on the rheumatoid elbow proved to be safe and efficient methods on a medium term even at late stages. Especially joint surface remodeling guarantees a noticeable increase for the elbow ROM without provoking marked collateral instability. The patients' expectations for pain relief and functionality can be fulfilled completely with these methods.
...
PMID:[Joint-preserving procedures for the rheumatoid elbow joint. Medium-term results]. 1295 94

An integrated multi-channel AMLAB-based data acquisition, processing and analysis system has been developed to simultaneously display, quantify and correlate electromyographic (EMG) activity, resistive torque, range of motion, and pain responses evoked by passive elbow extension in humans. The system was designed around the AMLAB analog modules and software objects called ICAMs. Each channel consisted of a time and frequency domain block, a torque and angle measurement block, an experiment number counter block and a data storage and retrieval block. The captured data in each channel was used to display and quantify: raw EMG, rectified EMG, smoothed rectified EMG, root-mean-squared EMG, fast Fourier transformed (FFT) EMG, and normalized power spectrum density (NPSD) of EMG. Torque and angle signals representing elbow extension measured by a KIN-COM dynamometer during neural tension testing, as well as signals from an electronic pain threshold marker were interfaced to AMLAB and presented in one integrated display. Although this system has been designed to specifically study the patterns and nature of evoked motor responses during clinical investigation of carpal tunnel syndrome (CTS) patients, it could equally well be modified to allow acquisition, processing and analysis of EMG signals in other studies and applications. In this paper, we present for the first time the steps involved in the design, implementation and testing of an integrated AMLAB-based system to study and analyse the mechanically evoked electromyographic, torque and ROM signals and correlate various levels of pain to these signals. We also present samples of resistive torque ROM, and raw and processed EMG recordings during passive elbow extension.
...
PMID:An integrated AMLAB-based system for acquisition, processing and analysis of evoked EMG and mechanical responses of upper limb muscles. 1295 88

In the context of comparative clinical studies in surgery and in orthopedic surgery different therapies, techniques, or implants have been compared. Recent scientific publications mainly mention clinical outcome measurements such as fracture union, ROM, infection rate, as well as patient-related criteria such as pain or return to work (RTW) in order to evaluate the success of the treatment. It becomes obvious that more often than not the term "return to work" is not clearly defined. It is not mentioned who measures which criteria at which point in time, nor are part-time occupation, job change, or training on a new job part of the considerations.
...
PMID:[Outcome parameters for clinical studies: change of paradigm?]. 1460 21

The clinical and radiographic results of 40 modern design condylar total knee arthroplasties (TKAs) in 29 patients with a confirmed diagnosis of Charcot joint were reviewed. The followup averaged 7.9 years (range, 2-15 years) for clinical and 6.4 years (range, 2-15) for radiographic surveillance. There was a significant improvement in Knee Society pain and function scores and ROM after knee arthroplasty. Extensive bone fragmentation and bone defect was present in 38 knees (95%). Metal wedge augments (10 knees, eight patient), autologous bone grafting (17 knees, 13 patients), and bone allografts (two knees, two patients) were used to reinforce the bony defects. Ligamentous instability necessitated the use of long stem components in 27 knees and rotating hinge prostheses in five knees. There were six reoperations for periprosthetic fracture (two knees, two patients), aseptic loosening (two knees, two patients), instability (one knee, one patient), and deep infection (one knee, one patient). Total knee arthroplasty may be offered to a select group of patients with end-stage neuropathic arthropathy. The basic principles of knee arthroplasty in restoring limb alignment, reinforcing bony defects by bone grafting or augmented prostheses, careful ligamentous balancing, and appropriate selection of constrained prostheses particularly are important in these patients. The technical challenges encountered during TKA in patients with neuropathic arthropathy, particularly in those with significant deformities, can require skills, implant systems, and methods usually reserved for complex revision arthroplasty.
...
PMID:Total knee arthroplasty for neuropathic (Charcot) joints. 1464 53

An intra-articular metallic spacer is evaluated for the treatment of isolated medial compartment OA. It is proposed that this implant can provide axial correction for a varus deformity, eliminate the pseudolaxity of the MCL, improve knee function, maintain ROM, and provide pain relief. One-and 2-year data are presented on 71 UniSpacer Knee System implants that were implanted in 67 patients (four had bilateral surgeries). The mean age and weight of these patients was 54 years and 94 kg (207 lb), respectively. The heaviest patient in the group weighed 168 kg (370 lb). All knees were evaluated using the Knee Society clinical rating system, Lysholm scoring scale, radiographic limb alignment, and ROM. The mean Knee Society knee score improved 169% in the 1-year group and 193% in the 2-year group. The mean Knee Society function score improved 31% and 65%, respectively. The mean Lysholm score improved 88% and 140%, respectively. Five implants (7%) were revised to total knee arthroplasty (TKA) and 10 implants (14%) were revised to another UniSpacer Knee System implant. The early results suggest that an intra-articular metallic spacer is a viable treatment option for OA in the younger patient.
...
PMID:Unicompartmental tibial hemiarthroplasty: early results of the UniSpacer knee. 1464 55

The Pain, Palliative and Supportive care group is one of 50 collaborative review groups that make up the Cochrane Collaboration, an international organization with the task of preparing, maintaining and disseminating systematic reviews of the effects of healthcare. Cochrane reviews are published cumulatively four times a year on the Cochrane library (CD-ROM and Web-based), along with other useful material such as a register of some 300,000 randomized controlled trials. The group has identified some 20,000 randomized trials in pain and 1,200 in palliative care. Reviews in progress are also published on the library as protocols. Full peer-review is undertaken for protocols and reviews. The Pain, Palliative and Supportive care group is an informal international team involving some 100 people from some 18 countries. The group has published 26 protocols and 17 full reviews with a further 50 reviews in progress. The task is huge and there is scope for further volunteers to help with the various tasks of writing reviews, peer reviewing and literature searching.
J Pain Palliat Care Pharmacother 2002
PMID:The Cochrane Collaboration Pain, Palliative Care and Supportive Care Collaborative Review Group. 1465 Apr 62

A Cancer Pain Structured Clinical Instruction Module (SCIM), with skills stations incorporating actual cancer patients, has been developed to enhance cancer pain education among our medical students. The Cancer Pain SCIM has not been compared with more traditional cancer pain education, thus the purpose of this study was to assess the effectiveness and durability of three educational methods for teaching cancer pain management to medical students compared with a control group. Four consecutive rotations of 32 third-year medical students participated in one of four cancer pain educational strategies: 1) control group with no formal cancer pain education, 2) CD-ROM self-instruction module on cancer pain, 3) a 2-hour Cancer Pain SCIM plus the CD-ROM information, and 4) Cancer Pain SCIM, plus CD-ROM, plus a structured home-hospice patient visit. The effectiveness of the educational interventions was assessed at 4 months post-instruction using a 4-component Cancer Pain Objective Structured Clinical Examination (OSCE). The main findings of this educational study are that: 1) all three educational groups performed better on the Cancer Pain OSCE at 4 months than the control group (P<0.05); 2) medical students receiving structured education on cancer pain management significantly out-performed students at 4 months compared with control or traditional instructional formats; 3) students receiving the Cancer Pain SCIM plus home visit performed highest on the pain management, physical exam, and communication stations of the OSCE; and 4) the SCIM format of education shows durability as assessed at 4 months post-instruction. The Cancer Pain SCIM has a unique potential to substantially improve the quality of cancer pain education.
J Pain Symptom Manage 2004 Apr
PMID:Equipping medical students to manage cancer pain: a comparison of three educational methods. 1505 Jun 61

The aim of this study was to describe the indication, planning, technique, rehabilitation, and clinical results after cryopreserved allograft meniscus transplantation. Forty consecutive patients, 33 men and 7 women (mean, 37.3 years of age), were evaluated at 1-year follow-up post surgery. Symptoms, patient satisfaction, ROM (range of motion), surgical time, blood loss, and surgical history were evaluated. Thirty-eight (95%) patients had previous total or partial meniscectomy (mean, 11.4 years ago). Preoperatively, chief complaints were knee joint line pain and swelling. Mean surgical time and blood loss were 123 min and 87 g, respectively. At 12 months postsurgery, 5% and 10%, respectively, complained of pain and swelling; ROM was 0 degrees -132 degrees. Thirty-eight (95%) patients were satisfied. According to the results, meniscus transplantation can lead to significant pain relief and satisfaction in young symptomatic meniscectomized patients. However, long-term results must be obtained to prove the effectiveness of this technique in prevention of degenerative joint changes.
...
PMID:Meniscus allograft transplantation using posterior peripheral suture technique: a preliminary follow-up study. 1516 76

Post traumatic stiffness in young subjects has been long considered a bad indication for total elbow arthroplasty. We present the case of a 48 year old woman with an elbow fracture, operated in childhood who developed progressive painful stiffness. After treatment with a cemented semi constrained Coonrad-Morrey total arthroplasty, we have obtained a good result at over 4 years follow-up. The gain of ROM is 40 degrees, the analogue scale for pain is 2.5/10 and the Mayo Clinic Performance Index for the Elbow is 80/100. The subjective impression is excellent and there were no complications.
...
PMID:[Semiconstrained total elbow arthroplasty for severe post traumatic ankylosis of the elbow: a case-report]. 1548 81

The validity with respect to presence or absence of CRPS I according to Veldman's criteria was assessed for measured pain, temperature, volume differences and limitations in range of motion. Evaluated were 155 assessments of 66 outpatients, initially diagnosed with CRPS I, but many of them not so on follow up visits. Pain was measured with VAS and McGill, temperature by infrared thermometry, volume differences by water displacement volumeters and limitations in range of motion by universal goniometers. Sensitivity, specificity, positive and negative predictive value of the measurement instruments at different cut-off points was calculated. Combined symptom scores were evaluated in a similar fashion. High sensitivity was found for the VAS, McGill, and range of motion. The specificity was overall lower, but highest values were obtained for volume differences. The positive predictive value was good for all measurement instruments. Negative predictive value was lower, especially for measurement of temperature and volume asymmetries. If sensitivity and specificity are equally important, VAS>3 cm, McGill>6 words, temperature difference>or=0.4 degrees C, volume difference>6.5% and ROM limitation>15% provide the best results. Using these cut off values, the highest value of sensitivity and of sensitivity and specificity combined, was found for a combination of VAS, McGill and ROM. The highest value of specificity was found for different combinations of 3, 4 and 5 instruments, all containing the VAS. We conclude that the measured pain, temperature, volume and range of motion can be used as diagnostic indicators for establishing presence or absence of CRPS I.
Eur J Pain 2005 Feb
PMID:Predictive value of symptom level measurements for complex regional pain syndrome type I. 1562 74


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>