Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The clinical findings in 20 patients with TMJ-crepitation (E1-group) and 19 patients with TMJ palpatory tenderness (E2-group) have been compared with the findings in 29 other patients with mandibular dysfunction (R-group). The patients underwent a clinical examination of the masticatory system and of the second distal interphalangeal joints (DIP II joints). No statistically significant differences could be found between groups with respect to clinical signs, occlusal interferences, or dental attrition. Loss of molar support was found to be significantly more frequent in the E1-group than in the R-group. The frequency of tenderness to palpation or pain on movement of DIP II joints was significantly higher in the E2-group than in the R-group. Periarticular bony swelling of DIP II joints was significantly correlated with TMJ-crepitation. The patients with TMJ-crepitation were considered to have TMJ-osteoarthrosis. The results of the present study indicate that patients with TMJ-OZ have a similar clinical picture to other patients with mandibular dysfunction and that molar loss plays a role in the etiology of TMJ-OA.
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PMID:Clinical findings in temporomandibular joint osteoarthrosis. 27 41

A series of 16 cases of chronic mallet finger deformity repaired with tendon flap from palmaris longus tendon or lateral band of extensor tendons is reported. Follow-up ranged from 1 to 4 years, the deformity has been corrected and pain disappeared in all cases. The active extention of DIP joints are 0 degrees in 12 cases and 5 degrees-15 degrees hyperextention in 4 cases. The active flexion of DIP joints are normal (65 degrees-80 degrees) in 11 cases, has 5 degrees-15 degrees flexion lag in 5 cases. The PIP and MP are normal in all cases. The anatomic basis of this procedure is narrated. The restoration of the anatomic continuity of the terminal extensor tendon reestablishes the coordinative effect between the long extensor tendon, intrinsic lateral band and oblique retinacular ligament and thus brings good long term result.
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PMID:[Treatment of chronic mallet finger with tendon flap graft. Report of 16 cases]. 130 23

Clinical features of vascular leiomyoma of the upper extremity which have not been described or have been described incorrectly are documented with a report of 11 consecutive cases seen within the past 11 years. All patients were followed without recurrence or surgical morbidity. Vascular leiomyoma has been described as a painful nodule found more frequently on the extensor surfaces, but in our experience spontaneous or paroxysmal pain is exceptional and the tumour tends to be located on the volar surface when it is in the hand. In the digit, they tend to be found at the base away from the midline, and not seen distal to the DIP joint.
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PMID:Clinical characteristics of vascular leiomyoma of the upper extremity: report of 11 cases. 144 2

In a prospective study six patients with dorsal fracture subluxation of the IP joint of the thumb or the DIP joint of the finger were treated conservatively using an extension block splint. The fracture size varied from 22% to 47% of the articular surface of the volar base of the terminal phalanx. Good or excellent results were reported in all cases except for one, which was fair. Only one case in the study complained of any pain, and this was minimal. Conservative treatment using extension block splintage for this injury is as good as a surgical approach.
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PMID:Dorsal fracture subluxation of the distal interphalangeal joint of the finger and the interphalangeal joint of the thumb treated by extension block splintage. 147 58

A total of 100 heterosexual adults of either sex with frequent episodes of recurrent genital herpes were allocated to treatment with either Genivir (DIP-253) 1% cream or placebo cream. All patients had genital herpes previously verified by a positive viral culture. The study was carried out as a double-blind parallel group trial. Fifty patients were allocated to each of the two treatment groups. The treatment was initiated within 24 hours after the first sign of a recurrence, and at the pretreatment examination all patients had developed typical lesions with blisters and/or sores. At baseline a sample for herpes virus culture and typing was obtained. The creams were applied four times daily for five days. Follow-up examinations were carried out on days 1, 2, 4 and if needed on days 7, 10 and 14. The major factor used for assessment of efficacy was the time to complete healing of all lesions. Duration of pruritus and pain were also recorded. In the group of patients treated with Genivir cream the time to complete healing was 3.3 days and in the placebo group 6.1 days. The difference was statistically significant (P less than 0.001). The mean duration of pain was 1.3 days in the Genivir group and 2.5 days in the placebo group: this difference also reached significance (P less than 0.01). The duration of pruritus was about the same in both groups. The active agent in Genivir, DIP-253, is a heterocyclic aromatic complex with confirmed anti-herpetic activity and with evidence of a local immunomodulatory effect. It was concluded that the efficacy of topical application of DIP-253 may be due to combined antiviral and immunomodulatory activities.
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PMID:Genivir (DIP-253) 1% cream versus placebo cream in the treatment of recurrent genital herpes: a double-blind study. 209 94

An 80-year-old female had been taking phenacetin-containing analgesics due to severe pain in her legs and headache caused by SMON since 1957. The total accumulated dose of phenacetin that she had taken was about 2.3 kg. She visited the department of urology in our hospital complaining of gross hematuria in May, 1987. DIP showed that bilateral kidney were atrophic and her left pyelogram was non-visualized. A solid mass was located in her renal pelvis on the CT scan. Under the diagnosis of a left renal pelvic tumor, nephrectomy was performed on her left kidney in January, 1988. Histological diagnosis was interpreted as a transitional cell carcinoma, at a grade 1 greater than 2 and interstitial nephritis was detected. She died 8 months after the operation because of lung and bone metastasis. In autopsy, interstitial nephritis of the right kidney was also recognized. Our case is the fourth report of renal pelvic tumor due to phenacetin abuse in Japan.
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PMID:[A case of renal pelvic tumor due to phenacetin abuse]. 223 97

Like the FDP, the FDS may be avulsed at its insertion. The diagnosis can be made based on a history of resisted extension, palmar pain and tenderness, lack of FDS function, and inability to completely extend the DIP joint secondary to the looping affect of the FDS. In the seven reported cases of FDS rupture no surgical intervention was required. This case represents a case in which surgical intervention was required secondary to an isolated avulsion of the FDS in a football player.
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PMID:Isolated traumatic avulsion of the flexor digitorum sublimis. A case report. 261 Feb 88

The importance of anatomical reduction of articular fractures and early mobilisation of these severe forms of trauma which frequently damage the extensor apparatus (58% of cases, led us to propose direct miniaturised osteosynthesis as described by the Nancy-Strasbourg team. Of the 1,000 cases of osteosynthesis performed between 1978 and 1985, we selected 12 fractures of the MP joint, 38 fractures of the PIP joint and 10 fractures of the DIP joint, differentiated into 4 stages according to the condition of the skin and tendons and into 9 categories according to the anatomical type and the site of the fracture. Direct osteosynthesis (screw, bolt, pin) was used in every case. The clinical results were evaluated in terms of the Total Active Range of Movements, the local trophic state, the amount of pain and return to work, for each joint. When well conducted and with effective skin cover, this technique allows almost normal reconstruction in simple fractures and is valuable in more complex fractures by preserving sliding of the tendinous apparatus due to early mobilisation.
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PMID:[Miniaturized osteosynthesis of articular fractures of the fingers. Results of a series of 60 cases]. 319 Mar 14

Pain-free stability in the DIP joint is essential for effective stable pinch. Distal interphalangeal joint injuries usually achieve this function when treated as described. Stiffness in the DIP joint is not ideal, but its presence after treatment is not a major functional limitation if the joint is painless and aligned in the proper position. Mallet fingers are common injuries that usually are treated in extension splinting. Profundus injuries are uncommon injuries that require a high degree of clinical suspicion and are complex to repair. Due to its close proximity, the PIP joint can suffer from coexistent, unrecognized injury. Furthermore, the uninjured PIP joint can become stiff from unnecessary splinting. Therefore, it is essential that the PIP joint be carefully assessed and treated, if necessary, so that full motion can be maintained in the PIP joint. As with any hand injury, treatment and rehabilitation of the DIP joint should be designed to be effective, yet should not compromise overall hand function. It is logical that the more traumatic the injury, the stiffer the joint will become. It is equally logical that more involved surgical repairs also have a high yield of postoperative stiffness. The treating physician is encouraged to share this knowledge with the patient prior to initiating treatment, as this will decrease patient dissatisfaction.
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PMID:Distal interphalangeal joint injuries. 327 73

A 63-year-old male was referred to us for investigation of gross hematuria and miction pain. DIP showed a filling defect on the left side of the bladder. This patient underwent through clinical and endoscopic staging which included chest X-ray and abdominal and pelvic CT scan. Biopsy of the tumor resulted in a diagnosis of squamous cell carcinoma of the bladder, grade 2. Total cystectomy and lymphadenectomy were carried out. Unfortunately this patient died 6 months after surgery because of local recurrence. We believe that future research should be directed toward adjunctive studies with radiation and chemotherapy.
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PMID:[Squamous cell carcinoma of the bladder--a case report]. 358 49


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