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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acute visual loss, pain, and redness in the left eye developed in a 61-year-old diabetic man. Results of ophthalmologic examination showed 4+ conjunctival hyperemia and chemosis, no light perception, and restricted ocular motility. Through a hazy cornea, a gas bubble was visualized filling about 50% of the anterior chamber. A vitreous tap disclosed myriad gram-positive rods with terminal and subterminal spores. Cultures of the vitreous grew Clostridium septicum, a gas-forming organism. Exploratory abdominal laparotomy showed a ruptured diverticulum of the sigmoid colon with acute peritonitis. In spite of intensive antibiotic therapy, the patient died approximately 24 hours after admission. Results of histopathologic examination of the postmortem left eye demonstrated massive necrosis of the intraocular structures with numerous gram-positive rods confined mainly to the retinal pigment epithelium (RPE), detached retina, and vitreous. To the best of the authors' knowledge, this is the second reported case of C. septicum panophthalmitis. Only 69 cases of clostridial infections with ocular involvement have been recorded previously in the literature.
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PMID:Endogenous Clostridium panophthalmitis. 358 22

The male C57BL/6 mice used in this study were the offspring either of untreated or lead treated (0.1% lead acetate (PbAc) instead of drinking water) parents. Offspring of lead treated parents were reared on 0.1% PbAc until weaning, and also given 0.5% PbAc to drink for 3 weeks prior to testing (Pb2 group). Offspring of untreated parents were either given 0.5% PbAc to drink (Pb1 group) or maintained on tap water throughout (Control group). Control (C) and lead treated mice were subdivided according to single- or group-housing; no confrontation ("unfought") or confrontation with a trained aggressor mouse ("defeated"). All the mice were then given a hot-plate pain test, in which paw-lick and escape latencies were recorded. In untreated mice, latencies were reduced after defeat. This effect was not seen in lead treated animals. Lead treatment increased latencies in most instances relative to the appropriate control group. The paw-lick latencies were less consistently affected than the escape latencies. Escape latencies, with one exception, were longer in the Pb2 group than in the Pb1 group. Treatment with naloxone of single-housed C and Pb2 was without effect, except for Pb2 treated undefeated mice: here, naloxone abolished the analgesic effect of lead treatment. Lead-induced analgesia is discussed in terms of central mechanisms of pain reception.
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PMID:Two types of chronic lead treatment in C57BL/6 mice: interaction with behavioural determinants of pain. 372 64

Responses induced by tooth pulp stimulation were studied in 27 gallamine immobilized adult cats. Single units were recorded from the amygdala using stainless steel microelectrodes. Of 57 amygdaloid neurons, 8 were responsive to only non-nociceptive (tap and/or hair bending) stimuli, 7 were responsive to both nociceptive (pinch) and non-nociceptive stimuli, 18 were responsive to nociceptive stimuli, non-nociceptive stimuli and tooth pulp stimulation, and the others did not respond to these stimuli. The neurons in the amygdala responsive to tooth pulp stimulation were localized in the nucleus amygdaloideus centralis (pars lateralis) [Acl], nucleus amygdaloideus centralis (pars medialis) [Acl] and nucleus amygdaloideus basalis (pars magnocellularis) [Abm]. The response induced by tooth pulp stimulation was depressed by morphine and reversed by naloxone. These results suggest that Acl, Acm and Abm in the amygdala may receive pain sensation evoked by tooth pulp stimulation. Moreover, there is a possibility that these nuclei may be related to the emotional component involved in nociceptive processing.
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PMID:[Effects of tooth pulp stimulation on single unit activity of the amygdala in cats]. 379 54

Four patients completed a 10-session out-patient pain management programme which included didactic information, relaxation training and cognitive-behavioural techniques. At the beginning and completion of the programme a number of measures were taken, including symptom inventories and a repertory grid designed to tap the patients' self-concepts and attitudes towards illness. These two sets of before and after measures were compared. No changes in the symptom inventories nor in daily visual analogue measurements of pain were shown. Despite this, the repertory grids showed a significant increase in the distance between 'as I would like to be' and 'like a physically ill person;' suggesting that physical illness had become less desirable. At the same time the distance between 'like a physically ill person' and 'like a hypochondriac' decreased, suggesting that these two concepts were less clearly distinguished in the patients' minds. Analysis of the raw data suggested that emotional factors were considered more relevant to physical illness at the completion of the programme. It would seem, therefore, that the main impact of our programme was on the patients' attitudes towards illness rather than on symptoms. Since attitudes may partly determine subsequent illness behaviour, it is encouraging to note changes here which suggest that our patients have adopted a more healthy view of physical illness.
Pain 1985 Oct
PMID:Self-concepts and illness attitudes in chronic pain. A repertory grid study of a pain management programme. 390 15

A technique is described that combines percutaneous epidural with peripheral nerve stimulation to provide limited paresthesia to a lower extremity. The peripheral electrode is placed percutaneously and positioned along the course of the anterior division fo the spinal nerve anterolateral to the vertebral bodies. This is accomplished by a modified epidural tap. Combined stimulation was carried out in 23 patients with intractable leg pain. Sixteen patients proceeded to chronic autostimulation; follow-up time extended to 18 months. The procedure proved simple; there were no perioperative and only few minor late complications. Results were similar to those from conventional epidural stimulator implantation. It is concluded that combined epidural-peripheral nerve stimulation constitutes a valid therapeutic alternative for patients with unilateral lower extremity pain.
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PMID:Combined epidural and peripheral nerve stimulation for relief of pain. Description of technique and preliminary results. 621 52

Chronic implantation of a stimulating electrode in the thalamic relay nucleus (11 cases), in the periaqueductal gray (1 case) and in the internal capsule (2 cases) was performed in fourteen cases which suffered from intractable pain. All these cases could get pain relief at least initial two months. Ventricular fluids were collected before and after stimulation with optimal combination of parameters, and measurements of beta-endorphin were performed by radio-immunoassay. Intrathecal morphine (1mg) injection was performed in eight cases. Cerebrospinal fluids were collected by lumbar tap before and 24 hours after morphine injection. beta-endorphin immunoreactivity was measured by the same method. Pain relief was judged to be excellent if the patient so claimed, and if he discontinued analgesics. Pain relief was thought to be good when it was not completely controllable by stimulation but was sufficiently improved that the patient could do without analgesics. It was thought to be fair when patient could not discontinue analgesics, and poor when patient could not get pain relief. We usually attempt to prevent the stimulation-tolerance by administration of the monoamine precursors , i.e., 1-dopa and 1-tryptophan, on the basis of the experimental observation reported previously. In somatogenic pain patients, the thalamic relay nucleus stimulation was performed in 7 cases (excellent; 3, good; 1, fair; 3) and the periaqueductal gray stimulation in one case (good).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Thalamic relay nucleus stimulation for relief of intractable pain. Clinical results and beta-endorphin immunoreactivity in cerebrospinal fluid]. 633 Jun

A 75 year woman with chronic vitreous hemorrhage underwent extraction of a senile cataract. Surgery was complicated by the flow of brown fluid from the vitreous to the anterior chamber, which was not entirely removed. Post-operatively there was pain, 2 mm of brown hypopyon and intraocular pressure elevation to 60 mm Hg with the preoperative diagnosis of endophthalmitis, a pars plana vitreous tap and instillation of intravitreal antibiotics was performed. Bacterial cultures were negative and the presence of erythrocyte "ghost cells" established the diagnosis of hemolytic glaucoma. As medical management proved ineffective, a pars plana vitrectomy was performed. One year post-operatively the patient had a visual acuity of 0.4-0.5, normal intraocular pressure without medication and evidence of an old branch retinal vein occlusion. The mechanism of hemolytic "ghost-cell" glaucoma in this case is discussed.
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PMID:[A case of secondary ghost cell glaucoma with pseudohypopyon after cataract extraction]. 647 Apr 16

The use of the intraventricular or subarachnoid administration of morphine in the treatment of intractable pain secondary to cancer is described. The drug, in doses ranging from 0.33 to 4.00 mg, was administered by the percutaneous injection of an Ommaya reservoir or by a spinal tap. The duration of analgesia ranged from 36 to 150 hours. The indications for and side effects of this type of therapy are considered.
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PMID:Use of intraventricular and intrathecal morphine in intractable pain associated with cancer. 654 51

A three-year survey following the introduction of an epidural service to a maternity unit is presented. 1,438 epidural blocks were attempted (a rate of 30%). Provision of pain relief was the principal indication. There were no serious complications or sequelae although minor complications or difficulties of insertion were noted in 21%. The procedure was abandoned in 1.5% and accidental dural tap occurred in 1.7%. Satisfactory pain relief was achieved in 90% during the first stage of labour and 71% during delivery. Of those who delivered, 47% retained an urge to bear down and spontaneous delivery occurred in 43%. 89% of patients interviewed were fully satisfied with, or considerably helped by, the epidural block. Incremental epidural doses were managed by midwives and it is argued that the midwife is ideally suited to this role providing she is trained and experienced and can call for immediate anaesthetic assistance.
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PMID:A three-year survey of an obstetric epidural service with top-up doses administered by midwives. 715 48

Single neuronal activity has been recorded extracellularly from the nucleus centralis lateralis (CL), ventralis lateralis (VL) and medialis dorsalis (MD) of the cat thalamus. The majority of the CL, VL and MD neurons were excited by nociceptive stimulation such as pinching the skin with serrated forceps and/or intra-arterial injection of bradykinin. The nociceptive neurons were also driven by non-nociceptive stimulation such as tap of deep tissues, bending hairs and an air-puff and/or joint rotation, and their receptive fields were large. After intravenous administration of either morphine or pentazocine, most nociceptive neurons became unresponsive to nociceptive stimuli, although they were driven by non-nociceptive stimuli. This suggests that morphine and pentazocine have a specific antinociceptive action on these nociceptive neurons. Intravenous naloxone reversed the antinociceptive action of morphine, but failed to reduce the action of pentazocine. This differentiation has an important functional significance.
Pain 1981 Feb
PMID:Antinociceptive action of morphine and pentazocine on unit activity in the nucleus centralis lateralis, nucleus ventralis lateralis and nearby structures of the cat. 723 11


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