Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The tract of Lissauer receives small caliber dorsal root fibers in addition to axons arising from dorsal horn neurons. The termination of Lissauer's tract and dorsal root fibers was examined in the C7 segment of the rhesus monkey spinal cord. The distribution of normal dorsal root afferents was mapped by labelling the C7 dorsal root ganglion with tritiated amino acids, and then compared with the degeneration of C7 dorsal root fibers following an intradural dorsal rhizotomy. To focus on the distribution of the small afferents, the degeneration following a Lissauer tractotomy was compared with the degeneration following dorsal rhizotomy and following selected lesions involving the large afferents. The survival times following the lesions and rhizotomies were varied to facilitate identification of groups of fibers and terminals which might degenerate at different rates. Both large and small diameter dorsal root afferents were found to exhibit the same rostro-caudal topography within the dorsal horn. The C7 root axons and terminals distribute throughout the mid-C7 dorsal horn grey. Proceeding rostrally through C6, the majority of the C7 root fibers ending in laminae I-IV shift to a lateral position. Proceeding caudally through C8, the C7 root fibers shift medially. Few of the small diameter C7 afferents entering via Lissauer's tract extend above C6 or below C8. Large diameter C7 afferents, arising as dorsal column collaterals, can extend several segments above and below C7. Autoradiography revealed label in all dorsal horn laminae, the heaviest always occurring in the substantia gelatinosa. After one day, label was absent over dorsal column and Lissauer's tract axons, suggesting that the label was mainly associated with fine axonal branches or possibly terminals. After six to ten days many axons were labelled and could be traced into the dorsal and ventral horn. Degeneration from the rhizotomies and lesions, as demonstrated with Fink-Heimer and Nauta methods, depended on the survival time. No degeneration products were present before three days. The large afferents begin to degenerate within the dorsal horn after three to four days and mainly terminate in laminae IV-VI; by 12 days they can also be traced into the intermediate and ventral grey. The small afferents, which include those serving pain and temperature sensibility, arise from the tract of Lissauer and distribute to laminae I, II and III. The tract of Lissauer consists of two populations, each containing small afferents. One population degenerates at three to five days and distributes mainly to laminae II and III (substantia gelatinosa); the other degenerates around 12 days and distributes mainly to lamina I and the outer zone of II. It is suggested that the exclusive termination of the small afferents to laminae I, II and III may be correlated with certain unique histochemical properties (e.g., high substance P and high opiate receptor binding levels) of these same dorsal horn areas...
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PMID:Distribution of the tract of Lissauer and the dorsal root fibers in the primate spinal cord. 40 97

DISH is a common systemic skeletal disease, probably of dysmetabolic and/or degenerative origin, yet of unknown etiology. It is observed in middle-aged or elderly patients of both sexes, and is characterized by ossification of the anterior longitudinal ligament on the antero-lateral aspect of the spine, and by ossifying enthesopathy, in both the central and the peripheral skeleton. Diagnosis is solely based on radiographic abnormalities, according to the so-called Resnick criteria. In the present study, the spines of 915 patients (414 males, 501 females, mean age: 65 years) were considered, and the peripheral entheses (heel, patella and elbow) of 494 of them (234 males and 260 females). The incidence of DISH was 14.09% (129 cases): 17.6% in males (73 cases) and 11.7% in females (56 cases). DISH strikes in the VI and VII decades of life most. The most affected sites of the spine were: the dorsal portion (100%), especially in the D7-D11 segment (93%); the lumbar spine in L1-L3 (81%), and the cervical spine, in the C5-C7 segment (69%). Peripheral areas of involvement were: pelvis (90%), heel (76%), elbow (46%) and knee (29%). The symptoms of DISH must be promptly detected: the disease is not asymptomatic, but presents with pain and stiffness in the spine, recurrent tendinitis and bursitis, and myelopathy.
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PMID:[Diffuse idiopathic skeletal hyperostosis. Review of diagnostic criteria and analysis of 915 cases]. 150 50

This article presents the case of a 41-year-old female physician complaining about frequent chest pain attacks and breathing difficulties. Disorders started six months previously after inexpert manipulation of the thoracic spine performed by a physiotherapist while massaging the patient's back. Numerous diagnostic examinations (CT of the thorax, MRI of the thoracic spine, esophagography, cardiological examination, pulmological examination) did not explain the cause of subjective symptoms. Although the patient, who came to our private practice setting for examination of the spine and possible manual therapy, did not complain about disorders in the region of cervical spine, on the basis of clinical examination, we suspected the cervicogenic angina (CA; the attacks of chest pain caused by cervical radiculopathy; earlier term "cervical angina" is terminologically inappropriate). Namely, by means of clinical examination, we found very restricted active and passive mobility of the cervical spine, hyperalgic skin zones in the dermatomes C6-TH4, spasm of the cervical extensors and upper parts of the trapezius muscle, hypoesthesia in the dermatomes C6-TH1 and decreased left triceps reflex. MRI examination of the cervical spine showed left side disc herniation at the C6-C7 segment. Using manual therapy (traction mobilization of the cervical spine, segmental mobilization, distraction manipulation in full Nelson position), the complete regression of subjective symptoms was achieved which confirmed cervical origin of the pain. By analyzing anamnestic data, we concluded that the inexpert manipulation of the thoracic spine (the patient was lying in prone position), which caused strong local pain, induced sudden extension-flexion reflex movement of the cervical spine which the patient did not notice at that moment because of the acute pain in the region of the thoracic spine, resulting in herniation of already degeneratively altered disc at the C6-C7 segment with consequential CA.
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PMID:[Cervicogenic angina. Chest pain caused by unrecognized disc herniation at the segment c6-c7: a case report]. 1906 59