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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The therapeutic efficacy of a 0.5% cuprimyxin plus 1% hydrocortisone acetate-water-base suspension was evaluated in 130 clinical cases of otitis externa in dogs and cats in various geographic areas of the United States. The otic microbial flora was studied before treatment in 125 (96%) of the dogs and cats, with multiple isolates recovered from mated from 70%, yeasts from 65%, and fungi from 5% of the animals. Evens though multiple drug reistance was frequently observed in the bacterial flora, all bacteria and yeast isolates were sensitive to cuprimyxin. Of the 130 treated animals, a statistically significant (P less than 0.01) favorable response was obtained in 84,6% and no response in 13;1%; in2.3%, the condition became worse. An adverse reaction (pain at the time of first application) was observed in 1 (0.8%) animal.
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PMID:Evaluation of a cuprimyxin-hydrocortisone acetate suspension in the treatment of otitis externa in dogs and cats. 46 67

The use of amniotic membrane as a biological dressing for thermal injury is simple and cheap and has been found to be superior to allograft and xenograft. The membrane prevents heat and water loss from the wound surface and acts as a barrier against bacterial contamination, thus aiding the healing process and reducing morbidity. Another clinically significant and important property of the membrane is its ability to offer marked relief from pain. Over a period of 30 months amniotic membrane was used to treat 15 cases of burn in a small hospital, with uniformly satisfactory results. The practical aspects of this method of treatment can easily be adopted by any hospital regardless of its available facilities.
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PMID:Burn wound dressing with human amniotic membrane. 49 35

Pain threshold elevations induced in rats following acute exposure to stressful cold-water swims and to inescapable foot shocks are significantly attenuated by hypophysectomy. The present study investigated the effects of hypophysectomy upon the dose-dependent and time-dependent analgesia induced by morphine and by the glucoprivic agents, 2-deoxy-D-glucose (2-DG) and insulin. Two reflex pain tests, the tail-pinch and the flinch-jump were employed. In normal rats, insulin induced prolonged (180 min) analgesia at doses of 16 U/kg on the tail-pinch test and 256 U/kg on the flinch-jump test. However, the same agents induced small and brief pain threshold elevations in hypophysectomized animals. By contrast, though 2-DG increased both measures in both groups, its effects were more marked in hypophysectomized rats. Hypophysectomized rats also exhibited a potentiated analgesic effect on both tests following high doses of morphine. On the other hand, low doses of morphine transiently increased tail-pinch thresholds in normal, but not hypophysectomized subjects. These data provide further evidence of multiple pain-inhibitory mechanisms in which the pituitary plays a complex, but integral part.
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PMID:Differential effects of hypophysectomy upon analgesia induced by two glucoprivic stressors and morphine. 50 10

The use of the water-soluble radiocontrast substance Dimer-X in lumbosacral myelography in 22 patients with a stable pain syndrome in the lumbosacral region showed that this method makes it possible to disclose the cause of the disease exactly and to reveal or rule out any neurosurgical pathology of this region. This examination is tolerated well by the patients, does not produce serious complications, and may be conducted in any neurosurgical institution.
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PMID:[Use of the water-soluble x-ray contrast substance Dimer-X in lumbosacral myelography]. 51 87

1. The daily water intake of adult Brown Leghorn hens was measured at water temperatures of 0, 10, 20, 30, 40 and 45 degrees C. The electrical activity of neurones in the nucleus ventro-lateralis anterior solitarii (NVLAS) of the medulla was also measured when the mouth was stimulated with water at the same temperatures. 2. There was a significant decrease in water intake when the temperature of the water was 10 or 45 degrees C. 3. There was an increase in activity of some of the NVLAS neurones with decreasing water temperature and this activity was in response to specific "cold" receptors. 4. Some NVLAS neurones were identified which showed an increase in activity at temperatures of 45 degrees C and more; it was concluded that these represented responses to thermal pain. 5. It is concluded that the effects of temperature on water intake may in part be explained by the behaviour of the oral receptors.
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PMID:Effects of water temperature on short-term water intake and medullary neuronal responses in the hen. 54 69

Clonidine was found to possess dose-dependent analgesic and antiwithdrawal activity. In mice, clonidine prolonged the tail flick latency and inhibited phenylquinone-induced writhing. In rats, it inhibited tail withdrawal from hot water and a pain response to pressure application on an inflamed paw. The effective doses of clonidine were different in the different tests employed, but they were always smaller than those of morphine. Naloxone failed to antagonize the analgesic actions of clonidine but effectively antagonized those of morphine. Phenoxybenzamine also did not alter the inhibition of tail flick-induced by clonidine. Clonidine suppressed morphine withdrawal body shakes in a dose-dependent manner as does morphine. This action of clonidine was not reversed by naloxone. In usual laboratory tests, clonidine appears to be an effective analgesic which antagonizes signs of morphine withdrawal.
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PMID:A comparison of clonidine with morphine for antinociceptive and antiwithdrawal actions. 56 95

Salivary thermolytic mechanisms (weight of salivary glands, effect of desalivation on water intake and body temperature, grooming activity) as well as escape behaviour and reaction to heat pain were studied in capsaicin-desensitized and control rats exposed to various warm ambient temperatures. Body temperature of the desensitized rats increased more than the controls' at all the ambient temperatures studied (32, 34 and 36 degrees C); however, significant differences in the mechanism of salivary cooling were obtained only at 34 and 36 degrees C. Central impairment of saliva spreading in desensitized rats seems evident. Complete surgical desalivation did not increase hyperthermia of control and desensitized animals in warm environments. Therefore other mechanisms, primarily vasodilatatory, must also be involved in the rat's thermolytic normal response. Although desensitized rats did not show a tendency to escape from the warm environment their response to heat pain was normal. In conclusion, it is suggested that heat perception in desensitized animals is impaired; however, the existence of some capsaicin-insensitive thermolytic mechanisms (prone extension of the body) cannot be excluded.
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PMID:Salivary cooling, escape reaction and heat pain in capsaicin-desensitized rats. 57 15

By means of experiments involving pin-pricking, compositions containing 10% ketocaine base in a mixture of 2-propanol, glycerol and water were found to produce a high frequency of block to cutaneous pain following application to volunteers under an occlusive dressing. The local analgesic efficacy was found to be directly related to the degree of saturation of ketocaine in the vehicle and time of application. The degree of hyperaemia observed in the treated skin areas was found to be related to the degree of local analgesia produced.
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PMID:Local effects produced on intact skin by epicutaneously applied anaesthetic formulations. An experimental study in man. 58 20

Diagnosis of zygomatic fractures in the emergency department is possible by history and clinical signs together with a routine series of facial bone x-ray films. Three case reports are submitted to illustrate this approach, one case with obvious clinical signs and x-ray findings and two "unclear" cases where either the physical findings or the x-ray findings were equivocal. There may be pain, tenderness, cheekbone displacement subconjuctive hemorrhage and numbness, enophthalmos, and blurred vision. A Water's view is recommended for x-ray films. Zygomatic fractures are best treated in five to seven days; eye signs indicate earlier treatment. To treat, expose the probable fracture site and reduce under direct vision. The zygoma can be immobilized by passing a Kirschner wire through the body of the zygoma medially towards and through the lateral wall of the nose and into the bony nasal septum.
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PMID:Zygomatic fractures in the emergency department: evaluation and treatment. 62 24

In anaesthetized rats, single fibres have been dissected from the tail nerves. Fibres were found which became excited when the temperature of water surrounding the tail was raised above 40 degrees C. Firing rate increased with stepwise increases in temperature, showing first a transient outburst followed by adaptation to a static level. Corresponding neurones were also found in the dorsal horn at the entry zone of the roots coming from the tail. The cord neurones had a higher threshold temperature of 42.5--45 degrees C. When the spinal cord was reversibly blocked by cooling in the thoracic region, then the threshold of the dorsal horn neurones was reduced to that of the afferent fibres. In addition, at suprathreshold temperatures dorsal horn activity was greater during cord blockade. We conclude that dorsal horn neurones responding to noxious heating are subject to a tonic descending inhibitory control.
Pain 1978 Feb
PMID:Noxious thermal input from the rat tail: modulation by descending inhibitory influences. 63 23


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