Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty-two scoliosis in total body involved children with cerebral palsy (CP) were reviewed. Mean preoperative angle was 13. Average follow-up was four years. Surgery included a single posterior (11 cases) or anterior (3 cases) approach and a double stage anterior and posterior procedure in 18 cases. Fusion was extended to the sacrum in 15 cases. Complications were numerous: 3 deaths, 15 postoperative complications in 10 patients. Most of them were septic and cutaneous. Cobb angle was 78 degrees before surgery, 28 degrees after surgery and 32 degrees at follow-up. Functional status was improved in most of cases. Pain disappeared in 2/3 of cases. Sitting position was acquired in all cases at follow-up; motor possibilities were improved in 1/4 of cases; associated medical pathologies (mainly respiratory) were reduced in 2/3 of cases.
Rev Chir Orthop Reparatrice Appar Mot 1992
PMID:[Surgical treatment of scoliosis in bed-ridden patients with cerebral palsy]. 128 82

Forty-seven patients with predominant corporeal thoracic, thoraco-lumbar or lumbar vertebral metastases were treated surgically by corporectomy. The vertebral body was replaced by acrylic cement sustained by a vertebral U shaped plate screwed to the adjacent vertebral bodies: this corporectomy was completed in 17 cases by a posterior approach. In 9 cases it allowed to treat a posterior epiduritis. The spinal metastases were symptomatic in 45 cases (pain and/or neurologic deficit); 22 of the operated patients were bed-ridden, either due to an important pain (16), or due to a severe neurological deficit (6). In 36 cases, the intervention was done on the spinal lord segment (7 times on the upper thoracic column). The patients were authorized to get up the fifth or sixth postoperative day. The functional results, at a price of 15 per cent of mortality during the first two postoperative months, were satisfactory and stable in time (particularly, 70 per cent of the operated patients with neurologic deficits were improved and 13 of the 21 bed-ridden became autonomous). The intracanalar decompressions controlled by a postoperative myelography, were nearly always total. The sets were stables in time when the block of cement was sustained by a metallic device. The mortality and the functional failure with pain and neurological impairment occurred essentially, when there was spreading of the tumor to the peri-vertebral soft tissues and when there was epiduritis extending beyond the bone lesion. Thus, to be perfectly efficacious, the anterior surgery of the vertebral metastasis, which gives durable and better results than the posterior one, should be soon enough integrated, in the global treatment of the metastatic disease.
Rev Chir Orthop Reparatrice Appar Mot 1992
PMID:[Treatment of metastases of thoracic and lumbar vertebrae with predominant corporeal involvement by osteotomy of the vertebral body and anterior approach with cement and screwed plate]. 128 83

Ninety-seven threaded acetabular prostheses (44 cups of Lord and 53 Motta, type cups) were implanted among which 72 were examined at an average follow-up of 5.9 years. After an initial phase of good tolerance, the results became rapidly degraded. Clinically, the lack of fixation was translated by a start up pain. On examination, the pain provoked by the opposed hip flexion was pathognomonic. A radiographic analysis of our checks allowed us to classify them in four types: Type I: painful hip, normal radiography or presence of a radiolucent line in one of the DeLee's zones; increased uptake at bone scanning. Type II: total radiolucent demarcation; Type III: axial migration; Type IV: migration and tilting; Finally analysis of our series with Kaplan-Meier method showed a survivorship rate at five years of 59.3 per cent. It is concluded that this kind of implant must be abandoned.
Rev Chir Orthop Reparatrice Appar Mot 1992
PMID:[Screwed acetabulum: results of 72 cases with a mean follow-up of 5 years]. 128 85

Twenty one patients have been reviewed with a mean follow-up of 4.6 years. If we except one acute case, the main indications were scaphoid pseudarthrosis (13 cases), Kienbock's disease (4 cases), carpal instability (3 cases) all accompanied by wrist arthrosis. The results were considered excellent and good in 65 per cent of the cases. Pain was improved in 90 per cent of the patients. Average mobility was 71 degrees (76 degrees before operation). Strength was improved in 19 per cent of cases but remained less than the normal side in 60 per cent. Among 15 manual workers 11 went back to the same work and 4 to an adjusted work.
Rev Chir Orthop Reparatrice Appar Mot 1992
PMID:[Excision of the proximal row of the carpal bones. Apropos of 21 patients]. 130 36

The endogenous peptide bradykinin is found in plasma and inflammatory exudates and has been implicated as a chemical mediator of inflammatory pain and hyperalgesia. Two subtypes of bradykinin receptors, B1 and B2, have been described, and antagonists for the receptor subtypes have been synthesized. The bradykinin analogs [desArg9,Leu8]BK and DArg[Hyp3,DPhe7]BK have been reported to have antagonist activity at the B1 and B2 bradykinin receptors in smooth muscle, respectively. Behavioral studies in rats indicate that the bradykinin analogs can block the algesic effects of bradykinin. We wished to determine the effects of bradykinin and the bradykinin analogs (B1 and B2 analogs, respectively) on cutaneous nociceptors in the monkey. In addition, we wished to determine the type of bradykinin receptor that mediates the sensitizing effects of bradykinin. Recordings were made from single C-fiber and A-fiber nociceptive afferents (CMHs and AMHs) that innervated hairy skin. Heat sensitivity before and after the injections was determined with a heat test sequence consisting of stimuli that ranged, in 1 degree C increments, from 41 degrees to 49 degrees C. Intradermal injections of vehicle (neutral normal saline) failed to alter the heat response of CMHs. Bradykinin (10 nmol in 10 microliters) evoked activity in 6 of 10 CMHs and sensitized all the fibers to heat stimuli. After the bradykinin injection, the mean heat threshold of the CMHs decreased from 44 +/- 0.5 degrees to 42.7 +/- 0.5 degrees C (mean +/- SEM, p less than 0.02), and the total response to the heat test sequence increased by 87% (p less than 0.002). In a related psychophysical study in human volunteers, the same dose of bradykinin resulted in a comparable (115%) increase in ratings of pain (Manning et al., 1991). Bradykinin also evoked activity in 10 of 17 AMHs and sensitized 8 AMHs to heat stimuli. Bradykinin failed to alter the threshold for activation of CMHs to mechanical stimuli as measured by application of von Frey hairs to the receptive field. In contrast to bradykinin, intradermal injection of the B1 and B2 analogs (10 nmol in 10 microliters) evoked activity in 2 of 6 and 0 of 5 CMHs, respectively. A noteworthy finding was that both analogs enhanced the response of CMHs to heat stimuli by 50% (B1 analog, 1.5 +/- 0.1; B2 analog, 1.5 +/- 0.2). The B1 (n = 10) and B2 (n = 5) analogs did not evoke activity in any of the 15 AMHs tested.(ABSTRACT TRUNCATED AT 400 WORDS)
Somatosens Mot Res 1992
PMID:The effects of bradykinin and sequence-related analogs on the response properties of cutaneous nociceptors in monkeys. 132 2

From 1983 to 1987, 50 adult patients who suffered total palsy of brachial plexus were operated on. The average follow up was 39 months. They suffered severe supra-clavicular lesions of all the roots. All the roots damaged in the scalenic area were grafted, the avulsed ones were not. One root was grafted in 23 patients, two roots in 9 patients, three roots in 5 patients, four roots in 1 patient. No root was grafted in 12 patients. An active flexion of the elbow (over M3+, M4) was recovered in 39 patients (76 per cent). An active adduction of the shoulder (m. pectoralis major) was recovered in 24 patients (48 per cent), and an active abduction (supraspinatus or deltoid) in 13 patients (26 per cent). Twenty seven patients had severe pain before surgery. After grafting, pain decreased in 17 (62 per cent. At follow-up, 31 of the 50 patients had no pain or mild pain. These results justify for the authors nerve repair in total palsy of brachial plexus by supra-clavicular lesions.
Rev Chir Orthop Reparatrice Appar Mot 1992
PMID:[Total paralysis of the brachial plexus caused by supra-clavicular lesions]. 134 Sep 28

The authors present a series of 186 cases of spondylolisthesis treated using 3 different types of arthrodesis: 84 by anterior arthrodesis, 35 by postero-lateral arthrodesis and 67 by combined arthrodesis. Slippage reduction was sought only in combined arthrodesis. The elimination of pain or a significant improvement were noted in 95 per cent of cases treated by anterior arthrodesis, in 74 per cent of those treated by postero-lateral arthrodesis and in 97 per cent of those treated by combined arthrodesis. The work resumption or professional rehabilitation rate was 89 per cent for anterior arthrodesis, 46 per cent for postero-lateral arthrodesis and 90 per cent for combined arthrodesis. Analysis of the clinical results according to the criteria of Stauffer and Coventry shows that good results were noted in 69 per cent of cases treated by anterior arthrodesis, in 43 per cent of those treated by postero-lateral arthrodesis and in 74 per cent of those treated by combined arthrodesis. A fusion rate of 86 per cent was achieved after anterior arthrodesis, 69 per cent after postero-lateral arthrodesis and 95 per cent after combined arthrodesis. Reduction had no effect on either clinical results or spinal statics in spondylolisthesis of less than 50 per cent. In the reduction of spondylolisthesis of more than 50 per cent, better results were obtained with the R. Louis technique than the Harrington technique in the restoration of spinal statics and maintenance of long-term clinical results.
Rev Chir Orthop Reparatrice Appar Mot 1992
PMID:[Surgical treatment of isthmic spondylolisthesis. A comparative study of 3 types of arthrodesis]. 134 Sep 31

Persistent pain below the tip of the lateral malleolus may occur after comminuted fractures of the calcaneus. The pain is the result of compression of the peroneal tendons or abutment between the calcaneus and the lateral malleolus. Computerized tomography clearly shows the etiology. In these cases, the excision of the tip of the lateral malleolus, procedure described by Isbister, was performed. The clinical results of fifteen procedures in thirteen patients who had persistent pain below the tip of the lateral malleolus after fracture of the calcaneus are reported. All the patients were completely relieved of lateral pain. Subjectively, for nine patients, the results were excellent (7) or good (2). 4 patients are not satisfied. In these cases, pain arising from the subtalar joint was the main complain.
Rev Chir Orthop Reparatrice Appar Mot 1992
PMID:[Resection of the tip of the lateral malleolus by Ibister's method in the treatment of painful sequelae of calcaneus fractures]. 134 Sep 36

The authors report 62 cases of De Quervain tenosynovitis treated from 1983 to 1990 by the same surgeon. The de Quervain's tenosynovitis is an inadequation between the volume of the abductor pollicis longus and the extensor pollicis brevis and their tunnel above the radial styloid process producing a mechanical tenosynovitis. This disease occurs mostly in women with an average age of 47 and almost never before the age of 30. Clinically the patients have pain and swelling above the radial styloid process. Most of the surgeons know today this disease, nevertheless complications may occur (Abductor pollicis longus luxation, disgratious enlargement and adhesion of the scar). The transversal incision provides a less disgracious scar. As the tendinous pulley is opened frequent anatomical variations of the tendons are found. A ventral capsular flap fixation with a subcuticular continuous suture is made. This fixation prevents any ventral luxation. Radial nerve neuromas or neuritis is constantly looked for. The authors expose and analyse the statistical data of this intervention's results with a 6 month minimal and 7 years maximal follow up.
Rev Chir Orthop Reparatrice Appar Mot 1992
PMID:[De Quervain's tenosynovitis. Transversal scar and fixation of the capsular flap]. 141 Jul 15

A burst fracture of T 12, without neurological impairment, was treated by plaster cast. Prior to treatment, there was a significant narrowing of the spinal canal, due to posterior displacement of a bone fragment. This was not modified by treatment, as the narrowing was unchanged on the second CT scan, done eight days later. At 17 months, there was no more narrowing on the CT scan, as a consequence of vertebral body remodeling. The patient had no pain and performed several sport activities.
Rev Chir Orthop Reparatrice Appar Mot 1992
PMID:[Remodeling of the spinal canal after comminuted fracture of the spine. Apropos of a case]. 141 Jul 18


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