Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 16-year old girl developed multiple, well-demarcated, extremely painful, hyperkeratotic nodules on her left sole. Histologic examination revealed a cornoid lamella and transepidermal elimination of blood vessels and collagen fibers which may be caused by the acceleration of keratinization. The pain and tenderness may have been partially related to epidermal disruption.
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PMID:Porokeratosis plantaris discreta. A case showing transepidermal elimination. 323 53

Clinical treatment with a self-dissolving collagen bandage lens was studied in 29 eyes. The lens was used in ten eyes with corneal abrasion, seven with lamellar perforating corneal injuries, six with corneal abrasion following foreign body removal, two after pterygium surgery, in one corneal abrasion caused by radiation, in two eyes with photoelectric keratoconjunctivitis, and in one patient with a trophic-sterile corneal ulcer. In all cases wearing comfort was excellent and no allergic reactions were observed. The patients with corneal abrasions experienced a significant reduction in pain immediately after application of the lens, so that no pressure patch was necessary. In the cases with corneal abrasion due to radiation and trophic-sterile ulcer, re-epithelialization occurred more rapidly than with the customary treatment.
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PMID:[Clinical experiences with a therapeutic collagen contact lens. Initial results]. 323 39

Ketorolac is a potent cyclo-oxygenase inhibitor used for the treatment of postoperative pain. It is known to have anti-platelet properties. The aim of this study was to determine the effect of ketorolac on haemostasis both alone and in combination with low dose heparin in 12 healthy male volunteers. Each volunteer received the following drug combinations in a double blind, placebo controlled, cross over manner: ketorolac placebo/heparin placebo, ketorolac active/heparin placebo, ketorolac active/heparin active and ketorolac placebo/heparin active. Ketorolac significantly prolonged bleeding time, inhibited platelet aggregation to arachidonic acid and collagen and platelet thromboxane production. Heparin had no effect on bleeding time or platelet function, but significantly prolonged the kaolin cephalin clotting time and increased anti-Xa levels. Ketorolac had no effect on the kaolin cephalin clotting time or anti-Xa levels and no interaction was found between ketorolac and heparin in any of the investigations. The prolongation of bleeding time seen with ketorolac is unlikely, to be of any major clinical significance as almost all subjects remained within the normal range; however, it should be used with caution in subjects with haemostatic problems.
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PMID:Haemostatic effects of ketorolac with and without concomitant heparin in normal volunteers. 326 79

Temporomandibular joint affections in rheumatic disease are described. They were seen in inflamed joint diseases, mostly in rheumatoid arthritis, and less so in juvenile rheumatoid arthritis, psoriatic arthritis, Reiter's syndrome, ankylosing spondylitis, and collagen vascular disease. In osteoarthrosis, the temporomandibular joint affection occurs frequently but pain seems to occur most infrequently. We must bear in mind that a painful temporomandibular joint could be a symptom of myalgia, especially fibrositis syndrome with its painful tendon.
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PMID:[The temporomandibular joint from the rheumatologic viewpoint]. 329 80

37 keloid patients were treated with triamcinolone intralesionally every 15 days, in all 6 inoculations. Histologically after the treatment we observed alterations in dermal vascularization, in morphology, in color characteristics and in the arrangement of the collagen bundles. The disappearance of mucin and the presence of palisade granulomas was observed in some cases probably because of the corticoid deposited. There was regression of pruritus and pain in all the patients. We believe that the intralesionally infiltration of corticoid is even today one of the best methods of treatment, and it may also be effected together with other technics.
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PMID:[Clinico-pathological evaluation of keloids treated with intralesional injections of corticoid]. 330 1

In three patients neurologic complications developed after chemoembolization procedures were performed with cisplatin and a new collagen material. Three patients with dominant unilateral stage III cervical carcinoma were entered into an investigative protocol attempting to control regional disease and pain with chemoembolization. All three patients had previously undergone surgery, radiation therapy, and intraarterial chemoembolization or chemoinfusion. Each case was complicated by neurologic deficits. A collagen material was administered that acts at a precapillary level and reduces the likelihood of collateral flow. The size of the material enables it to embolize the small feeding vessels of the spinal cord and peripheral nerves. The patients in this study also had predisposing factors to neurologic sequelae including the previous therapy and the contributing neurotoxicity of cisplatin. The neurologic complications in these patients are not easily explained by knowledge of the neurovascular anatomy. Even with meticulous technique, intraarterial chemoembolization of the pelvis with cisplatin and collagen can be complicated by serious neurologic deficits.
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PMID:Neurologic complications of pelvic intraarterial chemoembolization performed with collagen material and cisplatin. 334 46

For a study of the ultrastructural pathology of chondromalacia patellae, we studied biopsy specimens that had been obtained at operation in twelve young patients who had pain in the anterior aspect of the knee due to mechanical derangement and also had the pathological changes in articular cartilage that are characteristic of chondromalacia. The initial pathological finding was swelling of the superficial matrix associated with breakdown of the collagen fiber network, especially at matrix streaks in the superficial and transitional zones. Fibrillated cartilage contained surface fissures that penetrated the middle layers. Amorphous electron-dense material was found covering the internal surfaces of the fissures; this appeared to contain degraded components of the matrix. In association with these changes, there were formation of nests of cells (clusters of chondrocytes) and increased numbers of organelles in the chondrocytes. A limited repair reaction also was observed in some specimens; this was characterized by the migration of fibroblast-like cells over the surface of the cartilage. The ultrastructural observations on these specimens from patients who had chondromalacia were compatible with a pathogenesis resulting from mechanical overload.
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PMID:An electron microscopic study of early pathology in chondromalacia of the patella. 273 74

One hundred and three teeth with chronic pulpitis, twelve chronic periapical lesions and eleven oral various soft tissue biopsies were used to discuss the presence, the anatomy and function of mast cells. The mast cell induces veinules dilatation during the early phase of inflammation by histamine release, collagen lysis, bone resorption and epithelium proliferation. It can be observed in every chronic lesion and plays a part in both humoral and cellular immunological phenomenons. A more accurate knowledge of its biochemical actions could help in understanding the mechanism of pain in certain clinical dental crisis.
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PMID:[Mastocytes and the oral cavity. Anatomy and function]. 346 Jan 57

Numerous musculoskeletal and collagen diseases can affect the cervical spine and TMJs as well as other joints in the body, resulting in pain and dysfunction. A rational approach has been presented to aid in the differential diagnosis of these disorders when they involve the TMJs. When systemic inflammatory diseases such as gout, psoriatic arthritis, and rheumatoid arthritis are suspected, the patient should be seen jointly with a rheumatologist to better manage medication and rehabilitation of the patient. Although rheumatologic diseases may appear complex, they can be differentiated and managed with minimal difficulty for the dentist. Early relief of acute pain and long-term successful management, however, will depend on the clinician's ability to understand the disease process, establish an accurate diagnosis, and apply the proper therapeutic measures.
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PMID:A rational approach to the differential diagnosis of arthritic disorders. 346 54

Recent findings in our laboratory indicate that adrenal medullary grafts produce significant alterations in pain sensitivity. Electron microscopic studies were undertaken to correlate these behavioral changes with the neural interactions of the host and graft tissue in the periaqueductal gray. A striking change found 8 weeks after transplantation is that pronounced myelination has taken place both in the graft and in the host tissue. The new myelin formation in the graft has the typical appearance of PNS myelination and, in the host the appearance of CNS myelination. The endothelial cells of the capillaries in the grafted tissue are attenuated and fenestrated in contrast to those of the surrounding parenchymal tissue of the host. By 8 weeks, the graft becomes heavily encapsulated with collagen, while the host CNS tissue develops layers of glial processes outlining the graft. However, collagen and glial layers apparently do not form an absolute barrier to either cellular or humoral interaction between the host and graft tissue. Chromaffin cells can be found protruding into the host CNS tissue and sometimes forming synapses with presumably the host neuronal processes. Grafted chromaffin cells may participate as both postsynaptic and, less often, as presynaptic components of synaptic junctions. The behavioral relevance of these synaptic contacts is unclear, since similar implants of adrenal medullary tissue into the dorsal spinal cord subarachnoid space, which also induce potent analgesia, do not contain synapses. Thus, it is more likely that behavioral changes are brought about by diffusion of neuroactive substances from grafted chromaffin cells to host receptors.
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PMID:Fine structure of adrenal medullary grafts in the pain modulatory regions of the rat periaqueductal gray. 362 96


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