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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Multiple mononeuritis of migrating nature at onset occurs in a variety of disease conditions. "Migrant sensory neuritis" without a systemic underlying disorder described by Wartenberg (1958) is the most distinctive form of this type of neuropathy. Its pathomechanism is not uniform, but angiopathy has been suggested by Matthews et al. (1981). In this report, we describe five cases of sensory-dominant multiple mononeuritis with migrating nature and without systemic visceral involvement. The patients consisted of four females and one male between 26 and 71 years of age. All showed recurrent episodes of sensory involvement along the distal branches of the cutaneous nerve. The patients presented with sudden onset of numbness or pain radiating along the cutaneous branches of the involved nerves often followed by persistent sensory deficit. In mild episodes, the sensory symptom with numbness almost completely subsided. The frequency of these episodes ranged from 7 times in 6 months to 6 times in 9 years. The clinical manifestations were similar or identical to those of migrant sensory neuritis reported by Watenberg and Matthews et al. Cranial nerve involvement and less frequent episodes in the present series differed from those in the previous reports. Laboratory examinations did not disclose any underlying disorder, suggesting systemic collagen vascular disease. Sural nerve biopsy study in two patients revealed vasculitis in small or medium-sized arteries in the epineurium as well as reduced population of large myelinated fibers. Small myelinated fibers were slightly increased in number, probably to regenerating fibers. Sensory action potentials were low or not evoked in the nerves examined.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Migrating multiple mononeuritis and nonsystemic angitis]. 255 95

Melioidosis is an infection of humans and animals caused by a gram-negative motile bacillus, Pseudomonas pseudomallei. Forty-nine patients with melioidosis complicating diabetes mellitus, collagen vascular disorders, leukemia/lymphoma, and other hematologic malignancies are described. Twenty-nine of these patients had disseminated/septicemic infection, two developed toxic shock syndrome, and one with AIDS experienced recrudescent melioidosis. Patients with disseminated melioidosis often have a variety of defects in cellular immunity both in vitro and in vivo. In humans with recrudescent melioidosis, cellular immunity can be transferred by a transfer factor and by levamisole, a cellular immunopotentiating agent. The results of the treatment of our patients with disseminated/septicemic melioidosis with antimicrobial agents in combination have been successful. In recent years, four cases of fungal arteritis due to Pythium species and one case of keratitis due to Pythium were seen. Almost all patients with fungal arteritis had thalassemia; all presented with pain in the lower extremities and gangrenous lesions of the toes. Pythium species, an aquatic Phycomycetes, was identified in these cases as a human pathogen on the basis of clinical features, pathologic findings, and--of greatest importance--the isolation of the etiologic fungi. These five cases with remarkably similar presentations exhibited certain similarities with and differences from cases of mucormycosis, entomophthoromycosis, and peniciliosis.
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PMID:Tropical disease in the immunocompromised host: melioidosis and pythiosis. 260 81

The evolution of the role of the physical therapist in the treatment of dysfunction in the stomatognathic system includes involvement in oral surgery and postsurgical repair procedures of the TMJ. There is no doubt that the multidisciplinary approach to treatment is essential to the effective treatment of a surgically repaired or restructured synovial joint. The surgical and therapeutic goals are to restore the joint, as much as possible, to a friction-free, pain-free, functional range of motion. To accomplish this, the practitioner must consider the normal structure and biomechanics of ligaments and tendons; the time frame for adequate collagen fiber biosynthesis; and the effects of immobilization, controlled mobilization, and exercise on ligament repair.
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PMID:Physical therapy for the postsurgical TMJ patient. 260

Three cases of maxillo-mandibular desmoplastic fibroma are added to the 41 cases already described in the literature. A synthesis of the actual knowledge concerning the tumor is presented. The tumor is mainly composed of fibrous tissue with bundles of mature collagen, and can be easily confused with a low grade fibrosarcoma. Most of the patients are caucasian males. It is a young people tumor (0 to 30 years) with a peak between 6 to 15 years. The mandible was involved in 36 cases and the maxilla in 8 cases. The left side was involved in a ratio of 2 to 1 compared to the right side. In the mandible, the tumor was observed most frequently in the body and at the angle of the jaw. Pain or tumefaction were the most prevalent clinical features. The etiology of the tumor is unclear but trauma is often implicated. When the treatment is conservative, recurrences are frequent. The maxillo-mandibular desmoplastic fibroma should be recognized early to avoid local tissue destruction.
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PMID:[The maxillo-mandibular desmoid fibroma. Synthesis of knowledge about a rare entity. Apropos of 3 cases]. 266 34

A 60-years-old woman with polycythemia vera with marked thrombocytosis and intolerable erythromelalgia was presented. A single dose of 400 mg aspirin was effective to improve the pain and cyanosis. And we studied the relationship between platelet aggregation rate and symptoms after administration of several antiplatelet drugs. A single dose of 100, 200, 400 and 800 mg aspirin, 25 mg indomethacin (Id), 200 mg OKY-046, and daily dose of 300 and 600 mg dipyridamole (Dp) and 300 mg ticlopidine (Tc) were given. Aspirin, Id and OKY-046 were effective for the improvement of finger pain. The complete inhibition of spontaneous aggregation (SPA) and aggregation by 2.0 micrograms/ml of collagen were well parallel with the improvement of symptoms. But duration of effect of LKY-046 were only 6 hours. Dp and Tc were not effective for the improvement of pain, had no relation with platelet aggregation rate. The concentration level of aspirin in vivo which suppresses the platelet aggregation induced by SPA and 2.0 micrograms/ml of collagen coincided well with the concentration level of this drug which suppresses the same platelet aggregation in vitro. It seems to be useful to suppress the platelet aggregation induced by SPA and 2.0 micrograms/ml of collagen with aspirin and Id for controlling the platelet aggregation induced circulatory disturbance in patient with thrombocytosis.
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PMID:[Clinical evaluation of the control of antiplatelet therapy through platelet aggregation rate on polycythemia vera associated with thrombocytosis and erythromelalgia]. 271 5

Elastofibroma dorsi was diagnosed in seven patients at the Columbia-Presbyterian Medical Center between 1976 and 1986. The ages of the patients ranged from 6 to 79 years (mean 49.3 years). No sex predominance was seen. Five cases of unilateral subscapular tumor and two cases of bilateral masses were identified. Four patients had pain with arm motion, and the remaining patients were free of symptoms. A nonencapsulated soft tissue mass elevating the scapula was identified by computed tomography. Incisional biopsy was performed in all cases, followed by local excision of the tumor. On gross examination, these lesions were firm and rubbery. Histologic evaluation demonstrated a slightly hypercellular fibrous tissue that contained variable numbers of fragmented elastic fibers. All patients with symptomatic tumors had complete relief of their pain after the operation. No recurrences were observed. Clinically, elastofibroma may mimic sarcoma and fibromatosis (extraabdominal desmoid tumors). Whether elastofibroma is a true neoplasm or a reactive fibrous lesion that produces not only collagen, but also abnormal elastic fibers, has been the subject of controversy and remains undetermined.
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PMID:Elastofibroma dorsi: benign chest wall tumor. 275 56

In this study, glutaraldehyde cross-linked collagen (Keragen implant) was injected subdermally beneath heloma durum and heloma molle for the relief of both the pain and keratoses associated with these lesions. Among 172 treated patients, 158 heloma durum and 44 heloma molle were treated with Keragen implant, whereas 121 heloma durum and 23 heloma molle served as uninjected controls that were treated only with palliative care. Most lesions (78% of heloma durum and 70% of heloma molle) required only one injection for correction and the mean treatment volumes were 0.46 ml. for heloma durum and 0.56 ml. for heloma molle. The incidence of pain, keratoses, and both pain and keratoses among Keragen implant-treated sites remained significantly lower than among control sites for up to 12 months after treatment. This is consistent with the data which demonstrated that the median time to recurrence of pain among implanted sites was 12.5 months, whereas it was only 2.0 months for control sites. Thus, these results indicate that subdermal injection of Keragen implant can provide significant reduction in the pain and keratoses associated with heloma durum and heloma molle.
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PMID:Report on the clinical evaluation of glutaraldehyde cross-linked collagen (Keragen) implant treatment of heloma durum and heloma molle. Collagen Podiatric Investigation Group. 294

Posterior scleritis must be considered in the differential diagnosis of many ocular conditions, including angle closure glaucoma, choroidal folds, optic disk edema, circumscribed fundus mass, choroidal detachment, and exudative retinal detachment. Because it is rare, a high index of suspicion is necessary. Anterior scleritis, pain, or a history of collagen-vascular disease, when present, help to alert the clinician to the correct diagnosis. Posterior scleritis affects women more often than men, but annular ciliochoroidal effusion and choroidal folds are more common in men. Exudative macular detachment and a circumscribed fundus mass are more common in women. This paper reviews the world literature on posterior scleritis and describes findings in a series of 43 patients seen at Wills Eye Hospital. It stresses the clinical features and ancillary diagnostic tests that help to establish the diagnosis.
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PMID:Posterior scleritis. 304 40

Glutaraldehyde cross-linked collagen, Keragen implant, was injected subdermally beneath tylomas for the relief of both the pain and keratoses associated with these lesions. Among 130 patients, 205 tylomas were treated with Keragen implant, while 185 tylomas served as uninjected control sites, which were treated only with palliative care. Most lesions (93%) required only 1 treatment; and the mean total volume implanted with 1.78 ml./lesion. The intensity and frequency of pain were lower among implanted lesions than among control sites up to 12 months following treatment. Furthermore, at 9 to 12 months following treatment, the extent of the keratotic lesions were reduced more frequently among the implanted lesions (45%) than among the control sites (27%); more nucleated lesions became non-nucleated for up to 12 months following treatment in the implanted group (61%) than in the control group (45%). Thus, these results indicate that subdermal injection of Keragen implant collagen can provide significant retardation in the formation of keratosis and reduction in the pain associated with tylomas.
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PMID:Report on the clinical evaluation of glutaraldehyde cross-linked collagen (Keragen implant) for the treatment of tylomas. Collagen Podiatric Investigation Group. 306 12

Treatment of dry socket using a specially formulated collagen paste was found to be more effective than a treaditional method (zinc oxide/oil of cloves). Collagen-treated patients were less likely to return for review, experienced less pain, showed less tissue reaction and required fewer treatments than zinc oxide-treated controls.
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PMID:Treatment of fibrinolytic alveolitis by a collagen paste (Formula K). A preliminary report. 308 16


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