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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Treatment of a split thickness donor site wound in 20 patients by means of a silicone gel sheet containing Ofloxacin, an antimicrobial agent, has been tested. For a comparison, each wound was divided into two parts, one for the silicone gel treatment and the other with a collagen sheet (10 cases) or an ointment-impregnated gauze (10 cases). Although Staphylococcus aureus was detected in three wounds treated with the collagen sheet, no wound treated with the silicone gel developed an infection even though the infected wound was adjacent. Results have shown that prompt epithelialisation occurred in the silicone gel-covered wounds, with little exudate and pain compared to wounds treated with either of the dressings. Although some wounds treated with the silicone gel tended to exhibit a slightly prolonged redness compared to wounds treated with an ointment-impregnated gauze, no subsequent cosmetic problem resulted.
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PMID:A silicone gel sheet dressing containing an antimicrobial agent for split thickness donor site wounds. 217 19

Musculoskeletal complaints comprise about 7% of all pediatric office visits. The differential diagnosis of these complaints is very extensive. A great diagnostic aid offer quality, distribution and temporal course of the pain of joints, bone and muscles, of an objectively detectable arthritis, and especially of the numerous manifestations of other organ systems: Constitutional signs, fever, skin, mucous membranes, eyes, nervous system, heart, vasculature, lungs, digestive system and urogenital system. Combinations of these often early manifestations are crucial to determine the disease category, which is urgent for further diagnostic measures and for therapy: Bacterial, rheumatic, collagen-vascular, traumatic, orthopedic, and neoplastic disease. They are as important for making the final diagnosis and for the early recognition of later manifestations and complications. To achieve an optimal diagnostic efficiency, laboratory investigations should be carefully selected according to the clinical findings and diagnoses. A few regular investigations are valuable for the assessment of disease activity and therapy, and others for the early detection of initially asymptomatic manifestations.
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PMID:[The significance of extra-articular manifestations for the differential diagnosis of musculoskeletal diseases in children]. 219 39

While there have been 5 cases of intraventricular arachnoid cyst published in the literature, the occurrence in the anterior horn of the lateral ventricle has not been reported. We report a case of intraventricular arachnoid cyst of the anterior horn causing attacks of orbital pain. A 30-year-old man was admitted with frequent attacks of orbital pain on his right side. Neurological examination revealed no abnormality. Plain CT showed a cystic dilatation of the anterior horn of the right lateral ventricle, and enhanced CT showed a deviation of the septal veins to the left side. T1-weighted MRI demonstrated a low-intensity mass in the anterior horn of the right lateral ventricle, and T2-weighted image demonstrated the mass as having high intensity. PEG in the sitting position showed no filling of air into the right lateral ventricle due to obstruction of the right foramen of Monro. The patient underwent an operation under a diagnosis of intraventricular benign cyst. The cyst wall was subtotally removed and the right foramen of Monro was opened. Histological examination of the specimen showed an arachnoid membrane with prolific collagen fibers. From an embryological point of view, the arachnoid membrane is derived from the arachnoid cell. We think intraventricular arachnoid cysts to originate from the remnants of the arachnoid cell on the tela choroidea or on the choroid plexus like intraventricular meningiomas.
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PMID:[Intraventricular arachnoid cyst appearing with attacks of orbital pain: case report and review of the literature]. 221 71

Numerous nodular xanthomatous lesions arose, gradually increasing in number on the back, chest, lips, tongue, and exposed "V" area of the chest on a 78-year-old man. Painful oral nodules and hoarseness developed subsequently. Histologic examination of the skin revealed a suppurative and granulomatous inflammation with an accumulation of acute polymorphonuclear neutrophils, nuclear dust, and xanthomatous histiocytes. Giant cells were rare and cholesterol clefts were absent. Biopsy of the oral mucosa and the larynx showed a similar process. Direct immunofluorescence was positive for vascular immune reactants at the basement membrane and fibrin in between collagen bundles. The patient had a serum IgA level of 432 mg/dl (normal level, up to 380), with normal IgG and IgM serum concentrations. A Raji cell assay was 240 micrograms/AHGEQ/ml (normal less than 5). CH-50 was decreased and C2, C4, and C3 were within normal limits. The dermatopathology was initially thought to be consistent with erythema elevatum diutinum, and the patient was treated with dapsone and prednisone, with a marginal response. There were no dermatopathologic findings of vasculitis. On review, the patient's dermatopathology was more consistent with necrobiotic xanthogranuloma (NXG). To our knowledge, this is the first report of an association of NXG with an IgA gammopathy and the second reported case of extracutaneous involvement with NXG.
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PMID:Necrobiotic xanthogranuloma with IgA paraproteinemia and extracutaneous involvement. 226 96

A living cellular allogeneic dressing made up of cultured keratinocytes adhering to a collagen film was used to treat 20 leg ulcers of various aetiologies in 16 patients. A reduction in pain was noted in 80% of cases, and promotion of granulation tissue in the ulcer bed in 70% of cases. In 10 patients, epithelialization of 71 +/- 29% of the ulcer was noted at Day 30.
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PMID:Treatment of leg ulcers with an allogeneic cultured-keratinocyte-collagen dressing. 227 37

Studies in the collagen and rabbit models of arthritis have indicated that indium-111 chloride (111InCl3) scintigraphy objectively measures synovial inflammation. Indium-111 chloride scans, with imaging three days after 19 MBq intravenous injection, were performed on 21 patients with definite or classical rheumatoid arthritis (RA), all of whom were functional class II. Standard clinical indices of disease activity were recorded at the time of imaging by the same investigator, who was unaware of the results of joint scans. In addition, eight patients with severe osteoarthritis, four of whom were considered to need hip or knee joint replacement, were similarly scanned. In each patient 16 joints were graded as 0 to 5, based on increasing degrees of 111InCl3 uptake, by a single investigator blinded to the patient's diagnosis and clinical status. In the group with RA significant correlations were observed between individual joint uptake on scan and peripheral joints with swelling, joints reported to be painful, and joints with any abnormality on physical examination. In the group with osteoarthritis joints positive on scan correlated with the presence of pain. A total scan score (sum of individual joint scores) was calculated for each patient. In the patients with RA values ranged from 0 to 42 with a mean (SEM) of 20.7 (2.7) and correlated with the number of swollen joints and decreasing grip strength. In the group with osteoarthritis the mean total scan score (9.2 (1.5), range 3-14) was significantly lower than in the patients with RA. These data show that 111InCl3 scanning can measure joint involvement by RA.
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PMID:Measurement of joint inflammation in rheumatoid arthritis with indium-111 chloride. 231 21

The present study investigated the interaction between the in situ dermis by using the donor site for split-thickness skin graft (STSG) and the cultured autologous epithelium in eleven individuals. Human epithelial cells were cultured according to the method of Rheinwald and Green, with some modification. The mirror-image site was covered by ointment dressing, and used as control. All of the grafted epithelial adhered to the wound bed within 7-8 days, and they were thick enough to be manipulated. On the other hand, the control areas didn't re-epithelize until 13-18th day postoperatively. Pain and exudate were remarkably reduced in all the cases, and there was less itching in 9 cases, as compared to the control areas (P less than 0.01; sign test). Even though there was no visual difference of scarring after 3 months, the grafted areas were much softer than the control areas in 8 cases (P less than 0.01). There was also a definite difference concerning pigmentation decrease in 5 cases. 7 days post-grafting, the cultured epithelium became thicker and more differentiated in 8-10 cell layers, and a well-developed basal lamina was observed by PAS stain and on electron micrographs. A 14th day specimen from the grafted area showed almost normal epidermis with melanin granules in the basal layer, despite of a mild intercellular edema among basal and spinous cells. Biopsies after 3 months revealed that there was less dermal fibrosis in the grafted areas than in the ungrafted ones. There appeared a tendency of rapid healing associated with minimal fibrosis, leading to satisfactory results. It is possible to infer that the epithelial-dermal interaction induced by cultured epithelial autograft may influence and regulate the formation of collagen and other extracellular matrix by fibroblasts. This study suggests that cultured autologous epithelium can provide a successful permanent skin substitutes in the donor site for STSG.
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PMID:[Clinical application of cultured autologous epithelium to donor sites for split-thickness skin graft]. 232 47

A rare case of congenital insensitivity to pain with anhidrosis is presented. The male patient, who expired at 17 years of age, was noted insensitive to pain and bouts of unexplained fever at birth. He frequently fractured the hands and feet with secondary osteomyelitis. He did not sweat even in warm season. The intradermal nerve fibres and sweat glands were normal in distribution. The peripheral nerve seemed to be almost normal with light microscopy but the electron microscopical study revealed extreme paucity of unmyelinated fibers and a reduction of myelinated fibres, especially of small caliber. Abundant collagen fibrils comprised the endoneurium. There were no regenerative and/or degenerative changes of axons and myelin sheaths. The pathology of the peripheral nerve was considered to be congenital. Our case might belong to a category of congenital sensory neuropathy with anhidrosis (Pinsky and Di George 1966), congenital insensitivity to pain with anhidrosis (Gillespie and Perucca 1960) or hereditary sensory neuropathy type IV (Dyck and Ohta 1975, Goebel et al 1980).
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PMID:Congenital insensitivity to pain with anhidrosis: morphological and morphometrical studies on the skin and peripheral nerves. 242 84

A 21 year old man complained of pain and burning sensation on the helices of both ears, precipitated by cold weather. Examination showed tender erythematous nodules. Biopsies of both ears showed the characteristic vascular and inflammatory changes of pernio. In addition, in the left ear, there were foci of necrotic collagen surrounded by palisaded histiocytes. The presence of necrobiosis in pernio has not been reported previously. In this case, necrobiosis would appear to have a vascular basis.
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PMID:Necrobiotic pernio. 248 49

Biomaterial implantation in animals is commonly used for biocompatibility studies as well as examination of long-term interaction between tissue and the test material. An in vitro cell culture model is proposed as an alternative which will save animal lives and reduce the pain and discomfort of animals used for such studies. In this study the biomaterial was matched to the cell types typical of the implant site of the particular material: porous calcium phosphate ceramic, used as dental and orthopaedic implants, with periosteal fibroblasts, osteoblasts and chondrocytes. All three cell types attached on to the ceramic and formed multicellular layers. Numbers of periosteal fibroblasts, osteoblasts and chondrocytes increased 29-, 23- and 17-fold, respectively, during the 10 wk period. Osteoblasts retained their phenotypic expression by producing only Type I collagen. Parathyroid hormone (PTH, 50 nM) suppressed the alkaline phosphatase activity of osteoblasts by over 50% and increased cAMP by more than 10-fold over control cultures.
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PMID:Growth of osteoblasts on porous calcium phosphate ceramic: an in vitro model for biocompatibility study. 254 Aug 46


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