Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven women patients at Tufts University School of Dental Medicine were evaluated for the subjective symptoms of a myofascial pain dysfunction. Each patient was evaluated by an occlusal analysis of the T-Scan computer to determine posterior disclusion time during excursive movements, and EMG analysis of the masseter and temporalis muscles. Each patient was then treated occlusally by developing immediate complete anterior guidance. This adjustment process involved the removal of all lateral and protrusive interferences prior to habitual closure adjustments. No attempt was made to retrude the mandible in centric relation, and splints were not used to deprogram the musculature before adjustment. In this study, protrusive movements and interferences were not examined, and there was no control group. Posttreatment EMG and T-Scan computer analyses revealed that by shortening disclusion times to less than 0.5 second in any lateral excursions, muscle function returned to normal in all seven patients in approximately 1 month's time. A direct correlation seemed to exist between contractile muscle activity and disclusion time. Lengthy disclusion time leads to excessive muscle activity that introduces spasm and fatigue of the masseter and temporal muscles. These results indicated that a partial explanation of the etiology of MPDS may be the time the molars and nonworking premolars remain in contact during excursive movements--a phenomenon termed "disclusion time."
...
PMID:Electromyographic and computer analyses of patients suffering from chronic myofascial pain-dysfunction syndrome: before and after treatment with immediate complete anterior guidance development. 836 63

A total of 46 variables were initially examined for their usefulness as predictors of treatment outcome in patients with facial pain diagnosed as either MPDS or an organic disorder, such as disease of the TMJ (for example, degenerative joint disease or inflammatory arthritis) or typical facial neuralgia. The information about each variable was collected from the patients prior to beginning of treatment. Data included sociocultural background, social group attitudes, sociomedical orientation, level of psychologic distress, symptoms and treatment history, behavioral and attitudinal responses to pain, and clinical findings. Two discriminant analyses were performed to determine the most important variables for predicting whether a patient would respond successfully (with either elimination of or significant decrease in pain) or unsuccessfully (no change or increase in pain) to conservative reversible treatment. The first analysis was used to reduce the original group of 46 variables to 18 variables, which were labelled "potential" predictors. In the first analysis it was noted that clinical factors, such as oral status and physical examination findings, were irrelevant for predicting treatment outcome. Of the 16 clinical variables initially included for analysis, only the presence of clenching was included as a potential predictor. Patients' psychologic status, as measured by their level of psychologic distress, was also not relevant. The greatest number of potential predictors was related to patients' sociocultural background, sociomedical orientation, symptom and treatment history, and behavior in response to and attitudes toward pain. These factors, then, appear to be more useful than clinical and physical data as indicators of the potential response of facial pain patients with either MPDS or organic TMJ deficits to treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
...
PMID:Predictors of treatment outcome in patients with myofascial pain-dysfunction syndrome and organic temporomandibular joint disorders. 658 9

One purpose of this clinical study is to establish a relationship between the hyper activity of the digastric muscles and predisposition of an individual to MPDS (myofacial pain dysfunction syndrome). If a population predisposed to MPD could be identified by an early diagnosis, intervention and treatment could eliminate potential pain in adulthood. Secondly, can the employment of electromyography to aid in the diagnosis of patients with MPD be helpful in establishing a program of prevention and treatment? Thirty-one patients, male and female, were randomly selected from among those routinely diagnosed as having myofascial pain dysfunction syndrome by the dental staff at the Long Island Center for Craniofacial Pain. Eighteen patients who did not experience any symptoms of facial pain comprised the control group in the study. This study demonstrated that the average trace readings which indicate the activity of the digastric muscles, as measured by the electromyogram from patients experiencing facial pain were significantly higher than those from patients without pain symptoms. In every instance, the correlation between facial pain and abnormal swallow patterns which are a cause of hyperactivity of the digastrics was confirmed.
...
PMID:Prevalence of hyperactive digastric muscles during swallowing as measured by electromyography in patients with myofascial pain dysfunction syndrome. 961 Feb 92