Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The use of indomethacin (Amuno, Indocid) to prevent postoperative complications following oral surgery was checked in double blind tests. Impacted and half-impacted lower third molars from 100 patients were surgically removed; 50 were given indomethacin orally and 50 were given a placebo. Postoperative body temperature and pain were recorded on the first and second days after surgery. Trismus and cheek swelling were also measured.
 ...
PMID:[Double-blind study on the anti-inflammatory effect of indomethacin after surgical removal of lower wisdom teeth]. 38 Sep 63

Heterotopic bone formation occurs in up to 70% of patients who have undergone a total hip arthroplasty. Although histologically similar to mature skeletal bone, the ectopic tissue limits postoperative motion and causes pain in 2% to 4% of patients. The ossification is classified and graded according to radiographic appearance. Males with bilateral hypertrophic osteoarthritis who have had prior hip surgery are at high risk. Prophylaxis with Indocin or low-dose irradiation treatment is effective. Excision and irradiation therapy can treat established bony bridges.
 ...
PMID:Heterotopic ossification after total hip replacement. 211 17

A 48-year-old male suffering with SUNCT (severe unilateral neuralgiform headache with conjunctival injection and tearing, rhinorrhea and sub-clinical sweating) presented in 1996 after a 10-year history of multiple failed therapies. The symptoms included strictly left-sided ocular, as well as facial and temple pain. The pain attacks were burning, sharp, shooting and occurred 25 times daily, lasting 2 to 3 minutes with tearing and conjunctival injection. There was no associated nausea or vomiting, but there was photophobia. No other autonomic changes were reported and the pain was not triggerable. Initially Indocin (indomethacin) was tried without significant benefit. Gabapentin (Neurontin) was then started with improvement at 1800 mg per day. The patient was then lost to follow-up for 3 years, as he moved from the Los Angeles area. He returned in 1999 having stopped the gabapentin after his prescription ran out in 1996, reporting the pain returned immediately. Again gabapentin was prescribed and at 900 mg three times daily he has been pain free for 12 months.
 ...
PMID:SUNCT syndrome responsive to gabapentin (Neurontin). 1204 67