Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Norvedan (2-phenyl-4-p-chlorophenyl-thiazole-5-ylacetic acid) has been investigated for anti-inflammatory activity using an 'adjuvant arthirits' in rats and for analgesic activity using a writhing test in mice and a pressure test in rats. At oral doses of 10, 30 and 100 mg/kg Norvedan caused a dose-related inhibition of the primary swelling of the paw injected with adjuvant and the development of secondary lesions was also inhibited. Writhing induced in mice by i.p. administered acetic acid was also reduced by Norvedan at oral doses of 30 mg/kg and above and the response was related to dose. Against pain induced in rats by application of pressure to an inflamed paw Norvedan alsp showed good activity which was present for at least 6 hr after dosing.
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PMID:The anti-inflammatory and analgesic effects of norvedan a novel, non-steroidal agent. 108 13

The efficacy of oral fentiazac (100 mg QID) was compared with that of paracetamol (500 mg QID) in a single-blind trial in 30 patients suffering from post-endodontic periodontitis secondary to infiltrative or abscessed pulpitis. Patients were allocated at random to two treatment groups and treated for four days. Over each of the four days, patients scored the severity of spontaneous pain and induced pain. The same symptoms were assessed by the investigator at 0, 48, and 96 hours. Special attention was paid to the occurrence of adverse reactions. A statistically significant difference favoring fentiazac was seen in the patients' assessments of induced pain (while eating) but not in the investigator's assessment of induced pain (percussion). There was no significant difference in the analgesic effects of fentiazac and paracetamol with respect to spontaneous pain scored by patients or the investigator. No side effects were seen. Fentiazac was shown to be an effective analgesic for use in this painful inflammatory condition.
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PMID:Single-blind clinical trial comparing use of fentiazac and paracetamol in postendodontic periodontitis. 388 39

A double-blind comparison of fentiazac and placebo was carried out in 40 adult outpatients with acute nonarticular rheumatism. By random assignment patients received either 100 mg of fentiazac four times a day for one week or an identical-looking placebo in the same dosage. Evaluation was based on improvements in movement-induced pain, pressure-induced pain, and patient's and physician's ratings of therapeutic effect. Fentiazac was significantly better than placebo and produced a similar incidence of side effects, both agents being well tolerated.
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PMID:Treatment of acute tendinitis and bursitis with fentiazac--a double-blind comparison with placebo. 675 36