Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A multicentre double-blind trial in general practice compared Butacote (enteric-coated phenylbutazone) 300 mg daily, ibuprofen 1200 mg daily, and a placebo in the treatment of rheumatic conditions. Each patient recieved two of the three treatments for one month each. Twenty-nine doctors admitted 193 patients. One hundred and sixty-eight patients (sixty-four with inflammatory polyarthritis, and sixty-three with osteoarthrosis) completed the study, which showed that Butacote was significantly better than both ibuprofen and placebo for the relief of pain and morning stiffness, and improvement of function. Butacote was significantly preferred to both ibuprofen and placebo by patients and doctors, to placebo by the patients. Ibuprofen was significantly better than placebo for relief of morning stiffness and for reducing the amount of supplementary analgesics. All three preparations were well tolerated and showed a similar incidence of gastric side-effects. It is concluded from this study that Butacote is more effective and as well tolerated as ibuprofen in the treatment of rheumatic conditions in general practice.
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PMID:Butacote and ibuprofen: a comparative assessment in rheumatic diseases in general practice. 33 8

The effectiveness of 400 and 800 mg. of ibuprofen was compared to that of 650 mg. of aspirin, 65 mg. of propoxyphene HCl, and placebo in 510 patients experiencing pain subsequent to oral surgical procedures. In double-blind study, patients were randomly assigned to one of five experimental groups and instructed to report the intensity of pain (complete, partial, or none) over a 3-hour period of evaluation. Ibuprofen, at both doses, was shown to be more effective for both degree and duration of relief from pain.
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PMID:Analgesic activity of ibuprofen (Motrin) in postoperative oral surgical pain. 34 32

12 dysmenorrheic volunteers (average age, 28 years) were studied after treatment with Ibuprofen, a nonsteroidal antiinflammatory agent. Intrauterine pressure was recorded after either placebo or Ibuprofen oral administration. 800-mg doses were used. The therapeutic action of this prostaglandin inhibitor was highly significant in reducing resting pressure (P.001), active pressure (P.001), and frequency of contractions (P.05). In addition, menstrual pain was significantly reduced (P.05). The success of this single dose of 800 mg makes feasible a more comprehensive clinical trial of Ibuprofen's therapeutic effects.
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PMID:The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrheic patients. 35 95

In a randomized crossover study 15 dysmenorrheic women were treated during two consecutive menstrual period, once with the potent prostaglandin-synthesis inhibitor: ibuprofen and once with an identical looking placebo. Each patient was medicated for 12 hours during the first day of her menstrual flow and was subsequently fitted with a cervical cup for the collection of menstrual blood during three hours. In these samples the concentrations of prostaglandin (PG)F and PGE were measured by radioimmunoassay. The patients receiving placebo had high PGF levels 135 +/- 27 ng/ml (Mean +/- S.E.) which were significnatly reduced by Ibuprofen to 24 +/- 5 ng/ml (P less than 0.001). The PGE concentrations decreased from 5 +/- 1 ng/ml to 2 +/- 1 ng/ml (P less than 0.05). Ibuprofen also reduced the menstrual pain significantly (P less than 0.001). These results substantiate the earlier conclusion that a causal relationship exists between effective treatment with PG-synthesis inhibitors and decrease in menstrual blood PG levels, intrauterine pressure and dysmenorrheic pain.
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PMID:Effect of ibuprofen on menstrual blood prostaglandin levels in dysmenorrheic women. 39 21

A double-blind comparative trial in 60 patients, using diclofenac (Voltarol) and ibuprofen (Brufen), showed a considerable improvement in morning stiffness amongst females in the diclofenac group. However, no significant differences was noted between these two drugs in relation to pain score, articular index or proximal interphalangeal joint size. Analysis of withdrawals and side-effects suggests that while ibuprofen may be slightly better tolerated, it is also associated with significantly more withdrawals due to lack of effect. No significant change in laboratory studies was noted, except for a slight decrease in mean haemoglobin levels. The trialist noted that all of the drop-outs and side-effects reported came from one hospital out of the four participating; this was possibly due to differences in pre-trial drug therapy and to the hospital being in an urban, rather a rural, situation.
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PMID:Diclofenac sodium (Voltarol): a double-blind comparative study with ibuprofen in patients with rheumatoid arthritis. 39 82

Ibuprofen, a prostaglandin synthestase inhibitor, was studied by double-blind technique to determine its value in relief of severe primary dysmenorrhea; 7 patients and a total of 23 menstrual cycles were studied. The amount of prostaglandin in the menstrual fluid of the 8 untreated cycles studied was higher than in nondysmenorrheic subjects. In the 7 ibuprofen-treated cycles, good to excellent relief of dysmenorrhea was recored which was associated with a 3- to 4-fold reduction in menstrual prostaglandin released. 5 placebo cycles revealed only poor or minimal relief of dysmenorrhea, and the menstrual prostaglandin released showed little difference from controls. There was a marked correlation between the severity of menstrual pain, as assessed daily by individual patients, and the level of menstrual prostaglandin released during the corresponding period. Results on menstrual fluid volume showed ibuprofen's effect to be inconsistent; however in some cycles a slight (10%) reduction in menstrual fluid volume was recorded.
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PMID:Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen: effect on prostaglandin levels in menstrual fluid. 47 40

Painful menses, one of the most frequent gynecologic complaints, is incapacitating for many women. It has recently been proposed that increased endometrial prostaglandin production and prostaglandin-induced myometrial contractility may be responsible for dysmenorrhea. In this prospective, double-blind, 3-way, crossover study, relief of pain by an antiprostaglanding drug, ibuprofen (400 mg), was compared with propoxyphene (64 mg) and placebo in 22 women with severe primary dysmenorrhea. Ibuprofen was significantly more effective in 18 patients when compared to the other 2 treatment regimens (P less than 0.001), while propoxyphene was superior to placebo in 13 patients (P less than 0.05). Prostaglandin E and F synthesis rates in endometrial biopsy specimens taken on the second day of treatment in 2 patients during each treatment cycle were lowest during ibuprofen in one case but showed no definite pattern in the second.
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PMID:Dysmenorrhea: treatment with an antiprostaglandin. 49 26

It was considered that double-blind crossover studies of therapeutic efficacy after acute injury could well be done in patients who required surgical removal of impacted wisdom teeth from both sides of the lower jaw. In the present trial 24 healthy patients received either placebo or ibuprofen (Brufen: 400 mg three times daily), a non-steroidal anti-inflammatory agent, for 5 days commencing the day before surgery. Treatments were given on the two occasions when impacted wisdom teeth were to be removed from one side or other of the lower jaw. A number of objective and subjective parameters were recorded for paired comparison of the post-operative courses, including swelling, trismus and pain. A mechanical device which allows simple and accurate measurement of cheek swelling is described. On the 1st, 3rd and 5th post-operative days in the ibuprofen group the measured swelling averaged 93, 89 and 82%, respectively, of that in the placebo group; the corresponding alpha-values were 0.35, 0.06 and 0.07. Patients with less swelling after ibuprofen were not always those with a high serum concentration of the drug. Ibuprofen significantly reduced pain on the day of the operation. This may at least partly account for less trismus and the preference of the patients for their post-operative courses with ibuprofen. Examination of various haematological parameters did not reveal any significant difference between the two operations. Subjective scores indicated that neither wound-healing nor bleeding was affected by ibuprofen, nor were any side effects detected.
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PMID:Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: a test with ibuprofen. 78 80

A controlled research has been carried out in 39 patients with osteoarthrosis in order to evaluate the efficacy of Indoprofen, a new analgesic-antiinflammatory compound. This product, a phenylpropionic acid derivative, was given by mouth at the dose of 600 mg daily for 7 days. For comparison a treatment with 900 mg daily of Ibuprofen for the same length of time was given to patients according to a double-blind cross-over experimental design. Significant decrease in overall pain intensity was observed together with significant improvement in motility. Indoprofen at the daily dose of 600 mg was comparable in efficacy with 900 mg of Ibuprofen in the relief of pain related to osteoarthrosis. Toleration of the drugs was very good.
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PMID:Indoprofen in the treatment of osteoarthrosis. A controlled trial in comparison with ibuprofen. 79

Ibuprofen is a new, mild analgesic agent that may be useful in the symptomatic treatment of rheumatoid arthritis and osteoarthritis. Results of clinical studies have shown that its beneficial effects in these conditions are comparable, but not superior, to those of aspirin. However, at recommended doses it has less anti-inflammatory effect than aspirin. Its usefulness as an analgesic in the treatment of other types of pain and as an antipyretic has not yet been established. Ibuprofen causes fewer adverse effects on the gastrointestinal system, including occult bleeding, than aspirin. Serious adverse reactions have not been reported. Thus, ibuprofen may be acceptable for use in patients who cannot tolerate aspirin or other antirheumatic drugs.
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PMID:Evaluation of ibuprofen (Motrin). A new antirheumatic agent. 117 55


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