Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Experiments were performed on cats under chloralose anaesthesia and immobilized by Flaxedil. The right saphenous nerve was stimulated with single rectangular electric pulse of 30V and A-fibers were blocked selectively by the anodal current so as to elicic the C-fiber input only. The cerebellar cortical field potential evoked by C-fiber input (C-CEP) was recorded on the contralateral vermian VI lobule surface. C-CEP can be inhibited obviously by injecting the morphine (0.5 mg/kg) intravenously. It indicated that C-CEP had the close concern with the slow pain information and might be regarded as the index of the slow pain. The effects of the EA at the "Zusanli" point on C-CEP were observed. The results as following: 1. The amplitude of C-CEP decreased obviously after the EA at the ipsilateral "Zusanli" (strength: 10V, duration: 0.2 ms, frequency: 5 Hz). 2. From 5V-30V the more the strength of the EA was, the more the inhibitory efficiency was. 3. The inhibitory efficiency of the EA at the ipsilateral "Zusanli" point on C-CEP was stronger than at the contralateral, and the strongest at the bilateral.
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PMID:[Effect of electro-acupuncture (EA) on response of cerebellar cortex to slow pain]. 251 21

When the A-fibers of the saphenous nerve were stimulated at a lower intensity which elicited the A-fiber input only, an evoked potential (A-CEP) which consisted of an early component with latency of 11.8 +/- 3.5ms and a late component with latency of 312.1 +/- 17.5ms could be recorded on the surface of the cerebellar cortex in cat. When A- and C-fibers were activated by stimulation at the strength of C-fiber suprathreshold, the latency and configuration of the evoked potential had no significant difference from one of the A-CEP. After A-fibers were blocked by the polarizing current, stimulation at the strength of C-fiber suprathreshold could evoke a characteristic C-CEP with latency of 134.2 +/- 18.4ms. In general, C-CEP whose maximal amplitude was recorded on the vermain lobule VI was a positive-negative potential and its phases were reversed in the deep layer of the cerebellar cortex. C-CEP had a smaller amplitude, a longer latency and a lower following frequency than A-CEP had. In comparison with A-CEP, C-CEP had a high susceptibility to the morphine. The results showed that C-CEP which was evoked by the selective C-fiber input and generated in the cerebellar cortex seemed to be a response to the information of the slow pain input. It was suggested that C-fiber input could reach the cerebellar cortex and elicited an evoked potential. When A- and C-fiber were activated at the same time, C-CEP might be inhibited by the A-fiber input.
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PMID:[Electric responses evoked by C-fiber input from saphenous nerve in cat cerebellar cortex]. 262 80

SUMMARY: The CD20+ variant of angiocentric T-cell lymphoma is an unusual type of T-cell lymphomas that present cystic changes in organs because of ischaemic necroses. The purpose of this study was to describe a case of CD20+angiocentric T-cell lymphoma, discussing its clinical, histopathological and immunohistochemical features, to analyze its proliferation kinetics and to consider its possible relationship to the Epstein-Barr virus (EBV) to understand better the pathobiological nature of the disease. METHODS: The clinical, histopathological, immunohistochemical and single-cell DNA cytophotometric features of the case were analyzed. In addition in situ hybridization was performed to detect EBV. RESULTS: The 24 years old woman was admitted to our Institute because of pain in the abdominal region and weight loss. There were enlarged lymph nodes on the neck, and biopsy was done. Histological diagnosis: angiocentric T-cell lymphoma, CD20+ variant. CD3, CD43, CD45RA and CD45R0 antigens were positive in the atypic lymphoid cells of the tumour and in cells infiltrating the vascular wall. DNA index was 0.8589 (hypodiploid). Tumour cells in G1 phase: 47%, S phase: 45.4%, G2 phase: 7.6%. Combined chemotherapy was administered because of clinical stadium IV/B of malignant lymphoma (5 CHOP-Bleo, CEPP, CEP, CMVE treatment). The disease showed gradual progression and the patient died 14 months after the first symptoms had appeared. CONCLUSIONS: In the last 13 years there were 5 cases of angiocentric T-cell lymphoma at our Institute. The CD20+ variant is rare, its clinical symptoms are special, the prognosis is unfavourable. The cause why we demonstrate this case is to call attention to a new treatment for these patients by immunotherapy using monoclonal antibodies against CD20 antigen.
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PMID:[Angiocentric T-cell lymphoma] 1205 Jul 63

Noxious stimuli in the esophagus cause pain that is referred to the anterior chest wall because of convergence of visceral and somatic afferents within the spinal cord. We sought to characterize the neurophysiological responses of these convergent spinal pain pathways in humans by studying 12 healthy subjects over three visits (V1, V2, and V3). Esophageal pain thresholds (Eso-PT) were assessed by electrical stimulation and anterior chest wall pain thresholds (ACW-PT) by use of a contact heat thermode. Esophageal evoked potentials (EEP) were recorded from the vertex following 200 electrical stimuli, and anterior chest wall evoked potentials (ACWEP) were recorded following 40 heat pulses. The fear of pain questionnaire (FPQ) was administered on V1. Statistical data are shown as point estimates of difference +/- 95% confidence interval. Pain thresholds increased between V1 and V3 [Eso-PT: V1-V3 = -17.9 mA (-27.9, -7.9) P < 0.001; ACW-PT: V1-V3 = -3.38 degrees C (-5.33, -1.42) P = 0.001]. The morphology of cortical responses from both sites was consistent and equivalent [P1, N1, P2, N2 complex, where P1 and P2 are is the first and second positive (downward) components of the CEP waveform, respectively, and N1 and N2 are the first and second negative (upward) components, respectively], indicating activation of similar cortical networks. For EEP, N1 and P2 latencies decreased between V1 and V3 [N1: V1-V3 = 13.7 (1.8, 25.4) P = 0.02; P2: V1-V3 = 32.5 (11.7, 53.2) P = 0.003], whereas amplitudes did not differ. For ACWEP, P2 latency increased between V1 and V3 [-35.9 (-60, -11.8) P = 0.005] and amplitudes decreased [P1-N1: V1-V3 = 5.4 (2.4, 8.4) P = 0.01; P2-N2: 6.8 (3.4, 10.3) P < 0.001]. The mean P1 latency of EEP over three visits was 126.6 ms and that of ACWEP was 101.6 ms, reflecting afferent transmission via Adelta fibers. There was a significant negative correlation between FPQ scores and Eso-PT on V1 (r = -0.57, P = 0.05). These data provide the first neurophysiological evidence of convergent esophageal and somatic pain pathways in humans.
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PMID:Neurophysiological evaluation of convergent afferents innervating the human esophagus and area of referred pain on the anterior chest wall. 2002 27