Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case of coronary artery spasm during oral surgery under general anesthesia is reported. The patient, aged 44 years, 160 cm in height, and 55 kg in weight, was scheduled for radical surgery for right maxillary sinusitis and was healthy except for the disease requiring surgery. Just before the start of the surgery, severe and persistent hypotension with tachycardia after local injection of 3% propitocaine with 0.03 IU/mL felypressin (Citanest-Octapressin) was followed by sudden ST elevations in the ECG. Immediate continuous intravenous injection of nitroglycerin was thought to be effective. The patient recovered without any sequelae.
Anesth Pain Control Dent 1992
PMID:A case of coronary artery spasm during oral surgery under general anesthesia. 129 88

Fifty women undergoing laser vaporization of the cervix for cervical intraepithelial neoplasia were randomly allocated to one of two groups. In one group the patients received no anaesthesia, in the other the ectocervix was infiltrated with 2 ml of Citanest with Octapressin (prilocaine 3% with 0.03 i.u./ml. of felypressin) immediately before the procedure. The pain experienced by each group was assessed immediately after treatment by visual analogue and verbal rating scales. The pain experienced by those women receiving local anaesthesia was significantly reduced as assessed by the visual analogue scale (P = 0.011) and this reduction was not quite significant by the verbal rating scale (P = 0.06). The Citanest group had less troublesome bleeding but the difference in bleeding between the two groups was not significant.
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PMID:A randomized trial of Citanest with Octapressin for relief of pain associated with laser vaporization of the cervix. 242 87

In a series 49 embolizations of 30 renal carcinomas, of which 21 were later nephrectomized, the early results of embolization with Gelfoam or absolute ethanol were compared. Embolization with absolute ethanol, using Citanest renal anaesthesia and a balloon occlusion catheter was significantly (p less than 0.001) more effective, and also caused significantly (p less than 0.05) less nausea or vomiting and almost significantly (p less than 0.10) less pain, compared with Gelfoam embolization.
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PMID:Embolization of renal carcinoma. Comparison between the early results of Gelfoam and absolute ethanol embolization. 391 77

Prilocaine (Citanest) has been shown to be a satisfactory alternative to lignocaine, with certain important advantages, including superior diffusion. The latter may be especially important in peribulbar anesthesia, where the level of diffusion is a critical factor in providing a timely, high-quality block. In a prospective randomized study, we compared the effectiveness of peribulbar vs retrobulbar administration of prilocaine. Eighty-seven patients undergoing elective intraocular surgery were randomized to receive either retrobulbar or peribulbar anesthesia with prilocaine 3% with felypressin and hyaluronidase. Pain of injection, akinesia, and anesthesia were evaluated at predetermined intervals after injection. Except for the fact that lid akinesia occurred earlier in the peribulbar group, there was no difference in the quality or rate of onset of overall akinesia in the two groups. Nor were there any differences in the pain associated with injection. Both groups had excellent operative anesthesia and akinesia.
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PMID:Peribulbar and retrobulbar anesthesia with prilocaine: a comparison of two methods of local ocular anesthesia. 811 1

This investigation evaluated the use and efficacy of prilocaine HCl (4% plain Citanest) for minimizing pain associated with the intraoral administration of local anesthesia. Clinical anecdotes support the hypothesis that prilocaine without a vasoconstrictor reduces pain during injection. To determine relative injection discomfort, use of 4% plain prilocaine was compared with use of 2% lidocaine with 1:100,000 epinephrine and 2% mepivacaine with 1:20,000 levonordefrin. Prior to routine endodontic procedures, 150 adult patients received 0.3 to 1.8 mL of local anesthetic via the same gauge needle without the use of a topical local anesthetic. Injection methods included buccal infiltration, labial infiltration, palatal infiltration, and inferior alveolar nerve block. Following each injection, patients were asked to describe the level of discomfort by scoring on a visual analog scale of 1 to 10, where 1 = painless and 10 = severe pain. Analyses via 2-way analysis of variance revealed no interaction between anesthetic and site of injection. However, there were statistically significant differences among the injection sites. Post hoc analysis revealed that prilocaine was associated with significantly less pain perception when compared to mepivacaine and lidocaine. These results suggest that differences in initial pain perception during transmucosal injection may be a function of the local anesthetic use, and prilocaine can produce less discomfort than the others tested.
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PMID:Evaluation of prilocaine for the reduction of pain associated with transmucosal anesthetic administration. 1085 65