Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Circumcision is the only surgical procedure, excluding cord-clamping and cutting, which is routinely performed on normal, healthy newborn infants, usually during the first two or three days of life. Apparently no analgesic technique has been described nor suggested in association with neonatal circumcision. This is the first description of a technique of penile dorsal nerve block in neonatal circumcision. In 52 instances using 0.5 ml of 1% lidocaine (Xylocaine) and a 1.2 cm number 27 gauge needle PDNB was successfully and safely introduced with consistent elimination of pain, rendering NC a painless surgical procedure.
 ...
PMID:Neonatal circumcision and penile dorsal nerve block--a painless procedure. 66 Mar 75

The evaluation of persistent hindfoot pain in patients with previous calcaneal fractures should include contrast examination of the peroneal tendon sheaths. The identification of extrinsic compression or displacement of the peroneal tendons may indicate that source of pain, the diagnosis being substantiated by temporary relief of discomfort following Xylocaine injection.
 ...
PMID:Peroneal tenography in previous calcaneal fractures. 111 4

Ten patients received retrobulbar bupivicaine (Marcaine) in conjunction with cyclocryotherapy for medically unresponsive postpenetrating keratoplasty glaucoma and were found to experience significantly longer postoperative pain than 20 patients who recieved lidocaine (Xylocaine) anesthesia. The duration of pain was correlated with the need for narcotic analgesis whenever possible. We encourage further investigation into the etiology of the discomfort after cyclocryotherapy employing retrobulbar bupivicaine anesthesia.
 ...
PMID:Prolonged pain after cyclocryotherapy performed with retrobulbar bupivicaine hydrochloride anesthesia. 112 8

The clinical effects of three lidocaine-containing solutions with and without frigen (freon-113) as a propellant, after different waiting periods, and with different dosages applied were investigated in 130 outpatients who were undergoing dental treatment in the maxilla under local anesthesia. They were divided randomly into five groups (A through E): (A) Xylocaine spray with frigen, two applications (20 mg lidocaine); (B) Xylestesin spray with frigen, two applications (14 mg lidocaine); (C) Xylestesin spray with frigen, three applications (21 mg lidocaine); (D) Xylestesin pump spray without frigen, two applications (14 mg lidocaine); and (E) no topical anesthesia. They were further divided into 12 subgroups to evaluate waiting periods between the application of the topical anesthesia and the injection (1, 2, or 3 minutes). Patients assessed the pain of the injection, intensity of numbness, and intensity of the taste on a visual analog scale; they also assessed the pain of the injection compared to former injections. Pain during injection was reduced by topical application of lidocaine. A waiting period of 2 minutes proved to be sufficient and can be justified to avoid impatience and increased numbness in patients. However, a 3-minute waiting period may be appropriate for sensitive patients. An increase in the dosage failed to show better analgesia. The pump spray without frigen proved to be effective.
Anesth Pain Control Dent 1992
PMID:Clinical investigation of potency and onset of different lidocaine sprays for topical anesthesia in dentistry. 139 79

The effects of three lidocaine-containing solutions with and without frigen (freon-113) as a propellant on cardiovascular parameters and oxygen saturation, after different waiting periods and with different dosages applied, were investigated in 130 outpatients undergoing dental treatment in the maxilla under local anesthesia. They were divided randomly into five groups: (A) Xylocaine spray with frigen, two applications (20 mg lidocaine); (B) Xylestesin spray with frigen, two applications (14 mg lidocaine); (C) Xylestesin spray with frigen, three applications (21 mg lidocaine); (D) Xylestesin pump spray without frigen, two applications (14 mg lidocaine); and (E) no topical anesthesia. They were further divided into 12 subgroups to evaluate the influence of waiting periods between the application of the local anesthetic and the injection (1, 2, or 3 minutes). Without topical anesthesia and after the 1-minute waiting period, cardiovascular parameters increased immediately after the injection; after 2- and 3-minute waiting periods the increases were far less pronounced. The mean oxygen saturations did not change during the observed period. The higher lidocaine dosage administered (21 mg) did not intensify the positive impact on the cardiovascular parameters compared to the lower dosage (14 mg). The new pump spray without frigen proved to be as effective as the traditional, ecologically harmful aerosol sprays.
Anesth Pain Control Dent 1992
PMID:Effects of different lidocaine sprays for topical anesthesia on cardiovascular parameters and oxygen saturation. 142 91

This study compared the efficacy of EMLA 5% Cream, Xylocaine 5% (lignocaine 5 per cent) and NUM (benzocaine 15 per cent, amethocaine 1.7 per cent) to a placebo in reducing the pain experience during needle insertion. In a random, double blind study three groups of twenty volunteers each had a paired topical anaesthetic/placebo placed bilaterally in the buccal sulcus of the upper premolar regions for two minutes, followed by the insertion of a standard 27 gauge needle to a depth of 5 mm. Pain experience was measured with visual analogue scales. Results showed that all three agents significantly reduced pain when compared with the placebo--EMLA (p less than 0.002); Xylocaine (p less than 0.05); NUM (p less than 0.005).
 ...
PMID:A clinical evaluation of three topical anaesthetic agents. 144 45

The irritation of the nerves of the anterior abdominal wall (nervi intercostals X-XII) may imitate salpingitis, appendicitis or intraabdominal adhesion. By gentle palpation of the wall of the lower abdomen, spec. in the region of the lateral part of the musculus rectus, the points of pain are to be localized. Xylocaine-injection may give a pain-relieve for a short period of time. Mostly, there must be an operation to loosen adhesions and to dilate the nerve-exits from the lateral part of the musculus rectus.
 ...
PMID:[Irritation of the anterior nerves of the abdominal wall--Ibrahim syndrome]. 148 88

Children with cancer experience a great deal of anxiety concerning their treatment and invasive tests such as bone marrow aspirations (BMAs) and lumbar punctures (LPs). Responses of pain, fear, and anxiety are well documented and may cause regression, developmental delay, sleeping and eating problems, nausea and vomiting, nightmares, and depression. Diagnostic and treatment procedures need not cause such adverse effects if sufficient pharmacological sedation, analgesia, and anesthesia are used. However, studies show that inappropriate interventions such as underdosing and limited use of medications occur because of certain myths, beliefs, and lack of pharmacological knowledge on the part of health professionals. Studies that specifically address premedication for painful procedures in children with cancer have shown that only a small percentage of children receive premedications and that there is no clear consensus or standard for either drugs or dosages. The issue of premedicating children before procedures remains controversial and deserves further investigation. This study explored the attitudes and perceptions of oncology physicians and nurses concerning medicating children before procedures. Findings showed that most pediatric oncology specialists medicate their patients before invasive procedures and that the most common premedications used are Versed; Demerol, Phenergan, Thorazine; chloral hydrate; Ativan; fentanyl; Demerol; and Xylocaine. Most pediatric oncology specialists believe that premedication is necessary for children for BMAs and LPs.
 ...
PMID:Premedicating children for painful invasive procedures. 149 58

The incidence of hypotension induced by spinal anesthesia in 154 ASA class I or II patients having Cesarean section and postpartum bilateral tubal ligation was studied. Xylocaine (2%) 60-65 mg was used for spinal anesthesia. There was 41.0% of patients in Cesarean section group developed hypotension induced by spinal anesthesia, and 13.5% in tubal ligation group. We found no correlation between the time after delivery and the occurrence of hypotension induced by spinal anesthesia. In addition, 20.3% of the patients in tubal ligation group required intravenous narcotics because of inadequate sensory blockade during skin incision, but only 9.0% in Cesarean section needed the same supplement which was due to visceral pain during intra-abdominal manipulation. We conclude that spinal anesthesia with 2% xylocaine is safe and effective in both Cesarean section and postpartum tubal ligation although a significant difference of spinal hypotension existed.
 ...
PMID:Incidence of hypotension induced by spinal anesthesia with xylocaine for cesarean section and postpartum tubal ligation. 152 96

Many people with facial pain suggestive of sinus disease are ultimately proved, through extensive investigations, to have intranasal pathology without sinusitis. The middle turbinates in close proximity to other mucosal surfaces have been implicated as a possible cause of the rhinogenic pain. Surgical removal appears to provide relief in appropriately selected patient population. Pre-operative assessment to date has been mostly exclusional. Inference has been made to the efficacy of topical vasoconstrictive and combined vasoconstrictor-anesthetic agents as a diagnostic and prognostic aid for postoperative pain relief. Thirteen patients with middle turbinate hypertrophy, and symptoms suggestive of chronic rhinosinusitis were fully assessed clinically and radiographically. Significant sinus disease was ruled out. They were selected for middle turbinectomy with or without septoplasty. Topical Xylocaine was applied intranasally when patients were symptomatic. Postoperative follow-up suggests that the Xylocaine test may be a good prognostic aid for surgical outcome for craniofacial pain of apparent middle turbinate origin.
 ...
PMID:Intranasal Xylocaine: a prognostic aid for pre-operative assessment of facial pain of nasal origin. 158 6


1 2 3 4 5 6 Next >>