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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lidocaine (60 mg/100 ml) was added to contrast medium (120 ml of Conray-60) in an attempt to decrease pain associated with leg venography in 100 patients. No side effects were seen, and there was a marked reduction in pain as reported by four different examiners in two separate hospital populations.
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PMID:Intravenous lidocaine: an effective analgesic for lower extremity venography. 50 67

Amipaque 280 mg I/ml and Conray meglumine 282 mg I/ml have been compared in a double-bind trial in cerebral angiography. Altogether 55 cerebral artery branches have been examined in 21 patients, who served as their own controls. The effect of the contrast injections on the intra-arterial blood pressure, pulse rate, ECG, circulatory rate and the patients' reactions were recorded under standardized conditions. The quality of the films was also evaluated. No significant difference in the cardiovascular effects of the two contrast media was found. There was a significant difference in favour of Amipaque in the discomfort of the patients--less pain and sensation of warmth. No serious side effects were observed.
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PMID:Clinical testing of Conray meglumine and Amipaque in cerebral angiography. 51 99

The addition of adrenaline to meglumine iothalamate (Conray 280) in double-contrast knee arthrography significantly improves meniscal coating, in both immediate and delayed films, when compared with iothalamate alone. The quality of coating is comparable to that with sodium meglumine ioxaglate (Hexabrix 320) without adrenaline. The addition of adrenaline to ioxaglate produces no significant improvement in arthrographic quality in either immediate or delayed films. The use of iothalamate with adrenaline is less expensive than ioxaglate alone, but this financial advantage has to be balanced against the significantly greater pain associated with the use of intra-articular adrenaline.
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PMID:A comparative study to evaluate the role of intra-articular adrenaline in double-contrast knee arthrography. 259 85

Fifty patients undergoing ascending phlebography of a lower limb were evaluated, in a randomized double-blind fashion, to compare the efficacy, patient tolerance, and safety of two different contrast agents. Ioversol-240 (MP-238), a new nonionic agent, and iothalamate-202 (Conray 43), an established ionic agent, were the contrast agents used. Twenty-five patients were injected with iothalamate and 25 with ioversol. The phlebograms were evaluated for diagnostic quality and the patients for symptoms, with special reference to complaints of heat and pain. No significant difference was demonstrated between the two agents in either examination quality or patient tolerance. No major contrast-related reactions were recorded. We conclude that ioversol-240 appears to be a safe and acceptable alternative to iothalamate-202.
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PMID:Ascending lower limb phlebography: comparison of ioversol and iothalamate meglumine. 266 Sep 58

A double-blind, parallel group comparison study of Hexabrix and Conray 325 for adult intravenous urography was performed. Sixty patients with a mean age of 54 years were included. Doses of contrast ranged from 0.5-1.1 ml/kg for both groups with a mean of 0.7 ml/kg. Hematology, urinary and biochemical laboratory tests were performed prior to the study in all patients and at 24 hours afterward in nearly half the group. Biochemical laboratory tests were done at 72 to 96 hours in approximately one third of the patients. Hexabrix proved satisfactory for standard urography at a chosen dose of 16 g of iodine (50 ml). There were no statistically significant differences in the diagnostic quality of the urogram in the two groups except for bladder filling. The decreased osmotic diuresis associated with Hexabrix necessitated delayed bladder filming for optimal evaluation. Excellent patient tolerance was achieved with less pain on injection with Hexabrix. There was one death in the Hexabrix group in a patient with multiple medical problems. Although the patient's medical problems appeared well controlled and did not meet specific rejection criteria, they almost certainly played a role in his death. Hexabrix may be useful for adult urography at a lower dose range, eg, 16 g iodine, than is typically used, which also may be cost effective (competitive) given the higher projected cost of the new low osmolar agents.
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PMID:Urography with a low osmolality contrast agent. Comparison of Hexabrix with Conray 325. 395 88

Levels of beta-endorphin immunoreactivity in cerebrospinal fluid were measured in 12 chronic pain patients undergoing the surgical implantation of an electrode into the periventricular gray matter. Cerebrospinal fluid fractions were collected following placement of a cannula into the third ventricle, following injection of metrizamide contrast medium into the ventricles, following implantation of the electrode, and following electrical stimulation. A second set of samples was collected on a non-surgical day before and after stimulation. Levels of beta-endorphin immunoreactivity increased significantly from baseline levels to post-electrode implantation in one group of patients, but no significant change was seen following the onset of stimulation. Immunoreactivity increased significantly following metrizamide injection in a second group and was still elevated, in comparison to baseline, following electrode placement, but no increase was seen following the onset of stimulation. Levels of immunoreactive beta-endorphin did not increase in either group after stimulation on a post-surgical day, despite consistent reports of pain relief. Addition of metrizamide or a related contrast medium, iothalamate meglumine (Conray) to the beta-endorphin radioimmunoassay revealed that both compounds interfered with antigen-antibody binding and also quenched the gamma radiation emitted by iodinated peptide ligands. Due to these combined effects, the contrast media alone produced results similar to those of the beta-endorphin standard. Moreover, similar observations were made when contrast media were incorporated into radioimmunoassays for met-enkephalin, dynorphin and cholecystokinin octapeptide. These findings indicate that increased levels of beta-endorphin in cerebrospinal fluid are not directly associated with patient report of pain relief following periventricular gray stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)
Pain 1984 Dec
PMID:Contrast medium causes the apparent increase in beta-endorphin levels in human cerebrospinal fluid following brain stimulation. 609 57

Iopamidol (280 mgI/ml) was compared with Conray 60 (iothalmate meglumine, 282 mgI/ml) during selective and superselective cerebral arteriography. Twelve patients were examined, and a total of 51 selective injections were compared. Iopamidol produced significantly less pain and burning than Conray 60 and caused no patient motion.
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PMID:Iopamidol and Conray 60: comparison in superselective angiography. 637 48

In a double-blind study of 62 patients, Hexabrix was compared with Conray 60% in cerebral angiography. Both agents were injected into the same patient, the patient serving as his own control, and volumes injected into a single vessel were identical. Considerably less pain was experienced with Hexabrix. Changes in pulse, respiration and blood pressure were not significantly different. The two contrast media provided images of comparable quality.
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PMID:Tolerability and efficacy of Hexabrix in cerebral angiography. 639 58

A randomized double-blind study was performed in 27 patients to compare the clinical safety, incidence of pain and warmth, and film quality produced by iopamidol and Conray-60 in selective cerebral angiography. No complications or adverse reactions occurred in either group. Iopamidol was significantly less painful than was methylglucamine iothalamate for common carotid artery injections and caused significantly less heat in both common carotid and internal carotid artery injections. Film quality and diagnostic accuracy were excellent in both groups. These results, when viewed in conjunction with laboratory data demonstrating the decreased neurotoxicity of nonionic contrast agents, suggest that iopamidol is an important advance in the development of angiographic contrast media.
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PMID:Safety of contrast media in cerebral angiography: iopamidol vs. methylglucamine iothalamate. 643 83

One hundred patients were examined by ascending phlebography of both legs in a prospective, double-blind, within-patient study. Each leg was randomly allocated to the examination using either lopamidol 61% as the contrast medium. Immediate side effects were recorded in all patients, and delayed effects in 46 patients. Statistical analysis using the chi-square test showed that lopamidol produced significantly less immediate and delayed pain in the foot and the leg than Conray. Iopamidol produced significantly less nausea and vomiting during the injection than Conray. There was no significant difference in the quality of the phlebograms with either of contrast medium.
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PMID:Comparison of tri-iodoisophthaldiamide with meglumine lothalamate in phlebography of the leg. 703 76


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