Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three healthy men with psoriatic plaques unresponsive to tar, anthralin, and UVB were treated with 2450 MHz microwave heating for 30 minutes at 42 degrees C. Two patients had plaques over bony prominences. Pain developed in both patients, and one had a hypotensive episode during the first treatment. The third patient, whose plaque was greater than 2 cm and was not located over a bony prominence, completed the 5 weeks of biweekly treatments with complete resolution of the plaque and no complications.
J Am Acad Dermatol 1990 Apr
PMID:Complications of microwave hyperthermia treatment of psoriasis. 231 26

Many patients presenting for treatment of superficial varicosities and telangiectasias on the legs are seeking relief of pain or discomfort in addition to cosmetic improvement. Of 215 sclerotherapy patients, 114 (53%) complained of various painful symptoms involving areas of telangiectasias (vessels 0.1-1 mm in diameter) and varicosities (vessels greater than 1 mm in diameter). In order to determine whether sclerotherapy is effective in reducing leg pain and discomfort, hundreds of patients receiving two or more treatment sessions of compression sclerotherapy with hypertonic saline were surveyed for the pretreatment and post-treatment presence of numerous symptoms associated with telangiectasias and varicosities of the leg. For all symptoms combined, the overall reported relief of pain was 85% (p less than 0.001). Side effects from the treatment were minimal. These results indicate that sclerotherapy for telangiectasias and varicosities is not only a cosmetic procedure but a safe and valuable medical therapeutic modality, highly effective in relieving leg pain and discomfort.
J Dermatol Surg Oncol 1990 Apr
PMID:Resolution of pain associated with varicose and telangiectatic leg veins after compression sclerotherapy. 232 69

We describe the use of meshed local advancement flaps to repair surgical defects of the lower leg. The procedure produces a lattice of small cutaneous defects that heal rapidly by second intention. The technique is simple to perform and is suitable for large defects of the lower leg. Only minimal supervision is required post-operatively, and the wound causes virtually no pain.
J Dermatol Surg Oncol 1990 Apr
PMID:The use of meshed advancement flaps in the treatment of lesions of the lower leg. 232 71

Substance P (SP), S-100 protein, methionine-enkephalin, serotonin and myelin basic protein were studied in two solitary glomus tumours of the skin by peroxidase-antiperoxidase immunohistochemistry. Multiple SP-containing nerve fibres were distributed in the parenchyma of the tumour among proliferating glomus cells, and in the oedematous stroma of the tumour. Positive staining for myelin basic protein was detected in nerve fascicles in the capsule of the tumour, but not within the glomus tumour. S-100 protein immunoreactivity was found in nerve fascicles in the capsule of the tumour, and in addition, a few cells positive for S-100 protein were scattered throughout the stroma of the tumour. No positive staining for methionine-enkephalin and serotonin was found. The present finding may explain the clinical experience that the tumour is tender and can cause severe paroxysmal pain, because SP is known to be a primary sensory afferent neurotransmitter for mediating nociception. A possible role of SP for vasodilation in the glomus tumour is also discussed.
Br J Dermatol 1985 Aug
PMID:Immunohistochemical demonstration of substance P-containing nerve fibres in glomus tumours. 241 Dec 82

A 21 year old man complained of pain and burning sensation on the helices of both ears, precipitated by cold weather. Examination showed tender erythematous nodules. Biopsies of both ears showed the characteristic vascular and inflammatory changes of pernio. In addition, in the left ear, there were foci of necrotic collagen surrounded by palisaded histiocytes. The presence of necrobiosis in pernio has not been reported previously. In this case, necrobiosis would appear to have a vascular basis.
Australas J Dermatol 1989
PMID:Necrobiotic pernio. 248 49

A patient with phytophotodermatitis secondary to topical application of lime juice for relief of pain from a recent marine sting is reported. The absence of pain over the entire lesion and the failure of the patient to develop immune specific antibodies to common local coelenterates aided in establishing the diagnosis.
Australas J Dermatol 1989
PMID:Phytophotodermatitis: differentiation from jellyfish stings. 248 67

Twenty-two adults with persistent, symptomatic viral warts on the hands or feet which had failed to respond to conventional therapy were treated by carbon dioxide (CO2) laser ablation under local anaesthesia. Four patients did not return for follow-up treatment. Of the remaining 18 patients, 12 had plantar warts, the other six had warts on the hands that were mainly periungual. The median duration of the warts prior to laser treatment was 5 years. The areas treated were solitary in eight and multiple in 10 cases. After an average follow-up period of 10 months (minimum 6 months), all of the treated areas were clear of warts in 10 patients (56%), some had cleared in three, and all the treated warts had relapsed in the other five patients. Side-effects were commonly observed, especially post-operative pain, temporary loss of function of the treated part and scarring. The use of the CO2 laser may clear otherwise resistant viral warts but a significant morbidity may occur with this method of treatment.
Br J Dermatol 1989 Jul
PMID:Outcome of carbon dioxide laser therapy for persistent cutaneous viral warts. 250 21

3 patients with generalized neurofibromatosis were treated with the mast cell blocking substance Ketotifen. Pruritus and pain could be inhibited significantly and the tumor growth could be prevented.
Dermatol Monatsschr 1989
PMID:[Ketotifen inhibits urticaria and tumor progression in neurofibromatosis]. 251 Oct 44

We studied the therapeutic action of CO2 Laser on leg ulcers due to chronic venous hypertension in 30 subjects. Our findings show good results in reducing pain and leg oedema and wound healing.
G Ital Dermatol Venereol 1989 Jun
PMID:[Defocused CO2 laser in the treatment of leg ulcers. Preliminary results]. 251 23

A 65-year-old female suffered trauma to her left hand on which acrodermatitis continua (psoriasis of Hallopeau) developed. It is suggested that the persistent pain of this skin condition, its poor response to treatment and her allied mental state led to the development of a severe algodystrophy with marked underlying osteoporosis.
Clin Exp Dermatol 1989 Nov
PMID:Algodystrophy (reflex sympathetic dystrophy) complicating unilateral acrodermatitis continua. 260 10


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