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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The efficacy and tolerability of a new pharmaceutical formulation of a non-steroid anti-inflammatory drug, nimesulide were studied in a double blind study in comparison with flurbiprofen and diclofenac sodium, in 150 patients suffering from postsurgical pain-inflammatory symptoms. The three drugs, administered in a dose of one suppository twice a day for 10 days, showed marked anti-inflammatory, analgesic and antipyretic activity and produced a significant, progressive improvement in the typical symptoms of the inflammatory state. Nimesulide evidenced the greatest speed and duration of therapeutic action. Assessment on the efficacy and tolerability as expressed separately by the physician and the patients were positive in almost all cases of the three treatments.
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PMID:[A clinical study of the efficacy and tolerance of nimesulide compared to flurbiprofen and sodium diclofenac in the prevention and treatment of postoperative pain and inflammatory symptoms in dentistry]. 130 91

To study the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on uterine contractility in different parts of the uterus and on the direction and velocity of propagation of the activity, intra-uterine pressure (IUP) was measured simultaneously in 10 dysmenorrheic and 5 eumenorrheic patients with two microtransducer catheters at two locations (30 mm apart) before and after taking nimesulide, a newly developed NSAID. The uterus developed higher pressure cycles in the fundus than in the isthmus, in both eumenorrheic and dysmenorrheic conditions. Nimesulide did not affect either the active pressure (AP) or the direction and velocity of propagation of the activity, though it alleviated pain significantly. In dysmenorrheic patients, resting pressure (RP) is at a high level only in the fundus. The velocity of propagation ranged from 12 to 19 mm/s. The mathematical probability of procervical activity (1.0 if all procervical; 0.0 if all profundal), and thus the transport, was 0.59 in eumenorrheic and 0.68 in dysmenorrheic patients, the average for the whole series being 0.65. The luminal content (menstrual blood) moves in the cervical direction much more slowly than would be expected on the basis of simple calculations of velocity (velocity vector) of propagation.
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PMID:Analysis of uterine contractility after administration of the non-steroidal anti-inflammatory drug nimesulide. 131 39

The object of this study was the preliminary evaluation, in paediatric patients, of the analgesic and antipyretic effect of nimesulide given rectally. Nimesulide was studied in comparison with paracetamol, according to a double-blind technique. Forty-eight hospitalized children with fever or pain, between 1 and 8 years old, were included. The drugs were administered with a flexible posology (1 to 4 suppositories/day with an interval between administrations of at least 6 h). Monitoring of symptom intensity was scheduled in the 6 hours after each administration. At the end of the therapy the physician expressed a global judgement on the drug. Both treatments resulted in a significant decrease in body temperature at the 1 h observation. From the second hour onward, a more rapid tendency to temperature normalization was observed with nimesulide than with paracetamol. Repeated measurements with ANOVA did not show significant differences between treatments but the physicians' overall judgements were significantly more favourable to the nimesulide than to the paracetamol antipyretic activity. Good analgesic activity, favouring a rapid decrease in the painful symptomatology, was observed in both groups. No differences were found in the analgesic activity of the treatments, although in this case the clinical evidence was more favourable to paracetamol. Both drugs were very well tolerated.
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PMID:Pilot study of the antipyretic and analgesic activity of nimesulide paediatric suppositories. 164 12

The efficacy and tolerability of a new pharmaceutical form of the non-steroid anti-inflammatory drug. Nimesulide have been studied in a double blind study compared with flurbiprofen, in 98 patients aged between 18 and 75 suffering from pain-inflammatory pathologies of ENT nature. Both drugs, administered in a dose of one suppository twice a day for 7 days, showed marked anti-inflammatory, analgesic and antipyretic activity and produced a significant, progressive improvement in the typical symptoms of the inflammatory state up to their complete remission. Nimesulide evidenced greater speed and duration of therapeutic action. Assessment on the effectiveness and tolerability as expressed separately by the physician and patient were positive in almost all cases of both treatments.
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PMID:[Clinical study of the efficacy of and tolerance to nimesulide in suppository formulation in pain-inflammatory pathologies of the ear, nose, and throat]. 178 92

Nimesulide has been employed in maxillofacial surgery so as to assess the drug's anti-pain and anti-inflammatory properties. The study was carried out in double blind controlled form, using flurbiprofen as a reference: both medications were administered in suppository form at a fixed dose of two per day, corresponding to 400 mg/die of nimesulide and 200 mg/die of flurbiprofen. Forty adult patients were entered into the experiment and they were assigned to one or other preparation at random until two groups of twenty units each had been formed. Duration of the treatment was just a little more than six days on average and at the end it was possible to conclude that the two therapies were useful in the whole constellation of parameters considered but with some diversification: nimesulide in fact showed an ability to resolve the inflammatory process more readily and consistently than the reference, a tendency that was also confirmed statistically. Tolerability of nimesulide was perfect. There was one episode of diarrhoea with the reference.
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PMID:[The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen]. 209 87

The study assesses the effect of Nimesulide in the treatment of post-operative pain in minor orthopedic surgery. Twenty-five patients who had received regional peridural or subarachnoid anesthesia were included in the study. After a variable interval of 60 to 90 minutes, the average level of pain, evaluated using a "pain score", was considerably reduced. This effect lasted for an average of 360 +/- 120 minutes. There were minimum side-effects.
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PMID:[Nimesulide in the treatment of postoperative pain in minor orthopedic surgery]. 221 48

The aim of this clinical study was to value the antiphlogistic and analgesic efficiency of Nimesulide on 40 patients suffering from facial anomalies and subjected to corrective surgery with many facial osteotomies (Le Fort 1, sagittal osteotomy of mandibular ramus sec. Obwegeser-Dal Pont). Nimesulide was effective in reducing post-surgery oedema and spontaneous and caused pain. Besides it was of easy assumption and well suffered from the major part of the patients subjected to this kind of surgery.
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PMID:[Use of nimesulide in orthognathic surgery of the jaws]. 264 89

A Polycentric Study was carried out so as to assess the anti-inflammatory effectiveness and pain-killing activity of Nimesulide in Odontostomatological practice, in 78 patients suffering from alveolo-gingival and parodontal abscesses, consequences of tooth extraction, suppurated radicular cysts, dysodontiasis, osteitis, periodontitis, periostitis. The results obtained confirm the anti-inflammatory and analgesic effect as well as the good tolerability of this drug.
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PMID:[Nimesulide: multicenter clinical study for evaluation of its therapeutic effect in odontostomatology]. 265 74

A double-blind trial was carried out to assess the therapeutic efficacy and tolerability of nimesulide versus naproxen in the treatment of elderly patients with osteoarthritis. A total of 40 elderly female patients with osteoarthritis of the hip and/or knee were entered into the study and treated with either 200 mg/day nimesulide or 500 mg/day naproxen for 28 days. Both treatments were very effective in alleviating spontaneous pain, pain on movement, morning stiffness and joint mobility. Nimesulide was better tolerated than naproxen with fewer and less serious side-effects being reported. The results of this study show nimesulide to be effective and well tolerated in the treatment of elderly patients with osteoarthritis.
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PMID:Efficacy and tolerability of nimesulide in elderly patients with osteoarthritis: double-blind trial versus naproxen. 267 Jun 34

Nimesulide is a new non-steroidal anti-inflammatory analgesic agent given orally or rectally on a twice daily basis in a number of inflammatory and pain states. Although still at an early stage of clinical assessment, preliminary evidence suggests that nimesulide 200 to 400mg daily is significantly more effective than placebo in reducing the pain, fever and inflammatory symptoms of chronic rheumatoid arthritis or osteoarthritis, respiratory tract infections, otorhinolaryngological diseases, soft tissue and oral cavity inflammation, dysmenorrhoea, phlebitis/thrombosis, urogenital disease and postoperative pain states. In a number of comparative studies, nimesulide has also been shown to be more effective than piroxicam (in osteoarthritis), paracetamol (acetaminophen) [in respiratory tract inflammation], benzydamine or naproxen (in otorhinolaryngological disease), phenylprenazone (in laryngotracheitis/bronchitis, respiratory inflammation and otorhinolaryngological disease), Serratia peptidases (in postoperative or dental pain, trauma and phlebitis), ketoprofen (in postoperative dental pain) and mefenamic acid (in dysmenorrhoea). In addition, the efficacy of nimesulide has been observed to be comparable with that of aspirin, with or without vitamin C, and mefenamic acid (in respiratory tract infection), ibuprofen (in soft tissue disease), naproxen (in respiratory tract inflammation, dysmenorrhoea and postoperative pain states), suprofen and paracetamol (in postoperative pain states), benzydamine (in genitourinary tract inflammation) and dipyrone, paracetamol or diclofenac (in fever). The safety profile of nimesulide has yet to be fully established, although initial evidence suggests the usual adverse effects associated with non-steroidal anti-inflammatory drugs occur, possibly with a lower incidence of gastrointestinal problems than with other members in its therapeutic class. Nimesulide, therefore, appears to offer a useful alternative to other non-steroidal anti-inflammatory drugs in the treatment of patients with inflammatory conditions and/or pain and fever states. However, further definition of its efficacy and tolerability is clearly required, particularly in comparison with established or other new drugs in its therapeutic class.
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PMID:Nimesulide. A preliminary review of its pharmacological properties and therapeutic efficacy in inflammation and pain states. 306 59


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