Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new long-acting local anaesthetic, etidocaine (Duranest) has been compared to mepivacaine (Carbocaine) in retrobulbar anaesthesia in a double-blind trial including 45 patients. Solutions used were etidocaine 0.5% and 1% and mepivacaine 1%, all without adrenaline. The onset time was short and no difference was found between the solutions. The duration of analgesia and motor block was significantly longer with etidocaine 1% compared to mepivacaine 1%. In a following open study with etidocaine 1% and mepivacaine 1% about 80% of the the patients in the etidocaine group never experienced any post-operative pain compared to about 50% in the mepivacaine group. No signs of local or systemic toxicity were noted in the studies.
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PMID:Etidocaine in retrobulbar anaesthesia. A comparison with mepivacaine. 79 Aug 88

This study was performed on 40 healthy volunteers, and examines the onset, duration, subjective pain on injection, and sympathetic effects of two strengths of Polocaine, a brand of mepivacaine hydrochloride. The study demonstrated that Polocaine is a safe and useful, short-acting, local anesthetic. Polocaine is also a useful agent in causing local vasodilation for periods of time as long as 24 hr.
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PMID:Study of the sympathetic effects of polocaine in a regional hallux block. 233 69

This study was done to determine the clinical efficacy of a 15-mg diphenhydremine hydrochloride (Benadryl) local injection as a prophylactic treatment in the prevention of pain resulting from initial instrumentation of necrotic teeth. A double-blind study comprised of 37 subjects, each with one nonvital maxillary tooth, was completed in which patients were divided into two equal groups. The experimental group received a local anesthetic of 3% Carbocaine, followed by an additional injection of the antihistamine. The control group received the local anesthetic and an equivalent quantity of sterile saline. Patients recorded their pain levels at various time intervals: preoperatively, immediately postoperatively, and at 3, 7, 12, and 24 h postoperatively. Graphic analysis using a Quatro-Pro spread sheet program showed that there were no significant differences between the groups pain scores. However, there was a correlation between pain and time elapsed after procedure. In both groups, postoperative pain appeared to increase from 3 to 7 h and decrease from 7 to 24 h.
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PMID:Local prophylactic benadryl injections in an attempt to reduce postinstrumental pain. 793 Oct 28

Treatment of genital warts (HPV lesions) by Laser-surgery was performed in 90 patients and 90 male partners under topical anaesthesia with 1-3 gr EMLA cream and in 45 patients and 45 males (control groups) under 1-2 ml 2% Carbocaine infiltration. EMLA cream was applied to warts 5-18 minutes (median = 7) before operation. Pain from application of anaesthetic and Laser surgery was significantly less (p < .001) in the groups treated by EMLA. Side effects were minimal in the EMLA groups. The results suggest that EMLA cream could be the anaesthetic of choice in Laser surgery of genital warts.
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PMID:Vulvar and penile HPV lesions: laser surgery and topic anaesthesia. 839 52

This article describes the diagnosis and treatment of a patient exhibiting nonodontogenic tooth pain. A 25-yr-old female patient presented to postgraduate endodontics, SUNY at Stony Brook, for evaluation and treatment of pain associated with the upper and lower left quadrants. After thorough intraoral and extraoral examinations, it was determined that the pain was referred to the dentition from a trigger point in the masseter muscle. An extraoral injection of 3% Carbocaine was administered into the trigger point, and the pain abated within 5 min. The patient has experienced no recurrence of this pain for 12 months. Consideration of nonodontogenic dental pain should be included in a differential diagnosis.
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PMID:Toothache of nonodontogenic origin: a case report. 1450 37