Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An HIV-positive Pennsylvania inmate, [name removed], filed a lawsuit claiming that prison physicians were indifferent to his medical needs because they tried to wean him from addictive analgesics. [Name removed]'s suit alleged deliberate indifference to his pain. Prison physicians first prescribed Darvon, and then Percocet, a very powerful painkiller, to lessen [name removed]'s discomfort. However, a new medical director at the State Correction Institution at Mahanoy City determined that Percocet was not warranted, and initiated a gradual reduction in the dosage. [Name removed]'s lawsuit was dismissed by a Pennsylvania Federal judge.
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PMID:Denial of specific medicine is not 'deliberate indifference'. 1136 68

The most commonly prescribed class of medications in the United States for chronic severe pain is opioid analgesics. Due to their low cost and widespread availability, the synthetic opioids are popular choices among clinicians and patients. However, there is an increasingly recognized risk of QT prolongation with several drugs in this class, and recently propoxyphene (Darvon) was withdrawn from the market by the Food and Drug Administration (FDA) due to, in part, the risk of QT prolongation and ventricular arrhythmias Updated Epidemiological Review of Propoxyphene Safety. [FDA Alert]. Rockville, MD: U.S. Food and Drug Administration; 2010. Available from: http://www.fda.gov/downloads/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/UCM234383.pdf on 5 May 2012 .
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PMID:Synthetic opioids and arrhythmia risk: a new paradigm? 2256 97