Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the rat, oxotremorine increases the threshold for vocalisation after-discharge (affective component of pain reactions) dose dependently at subtremor doses (30-67 mug/kg s.c.). Doses of 225-506 mug/kg were needed to elevate the thresholds for vocalisation and motor response. 1-Tryptophan, PCPA, alpha-methyl-p-tyrosine, 1-Dopa, pimozide and LSD-25 did not affect the antinociceptive activity of oxotremorine, while phenocybenzamine slightly increased the threshold for vocalisation. Oxotremorine did not change the endogenous brain concentrations of noradrenaline and dopamine or 5-HT but decreased that of 5-HIAA in all brain regions at the time of maximal analgesia. The decrease of 5-HIAA was still present after pretreatment with probenecid. After inhibition of tyrosine hydroxylase, oxotremorine accelerated the depletion of dopamine in telencephalic cortex during maximal antinociceptive activity and of noradrenaline in all brain regions at a time when this activity had vanished. Atropine significantly antagonized the analgesic activity of oxotremorine. It is concluded that oxotremorine antinociceptive activity in the rat is related to a cholinergic compoent, while a monoaminergic component is not directly involved.
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PMID:Antinociceptive action of oxotremorine and regional turnover of rat brain noradrenaline, dopamine and 5-HT. 23 55

Some women undergo induced abortion manifest a series of symptoms such as slower heart beats, irregular heart rate, lowered blood pressure, paleness, dizziness and profuse perspiration. These symptoms, which occur during or after the procedure, are referred to as "a symptom complex." In 1977, 400 pregnant women were studied to determine the cause of this symptom complex: 263 healthy women who received normal treatment; 32 women with heart ailments associated with early pregnancy, who received acupuncture; and 105 women whose heart rates were below 90, who were injected with 0.5 mg atropine. Virtually all of the 263 women had a slower heart rate during the procedure. 33 (12.55%) of these women exhibited the symptom complex, and of these, 23 (69.17%) had cramps, 17 (51.52%) had abdominal swelling, and 2 (6.09%) had backaches. Most of these symptoms occurred when the cervix dilated and after the suction. The duration and seriousness of the symptom complex varied from woman to woman, as did the recovery period, which ranged from 3 to 63 minutes. It was also found that: 1) of the 263 patients, 110 were first time mothers, of whom 15 (13.63%) had the symptom complex; 2) of the 221 healthy women who had abortion by suction, 32 (14.48%) had the symptom complex, while 1 (2.38%) who had abortion by pincers, had the symptom complex; 3) of the 33 women who had the symptom complex, the loss of blood ranged from 10 ml to 200 ml, with an average loss of 50 ml; 4) there appears to be no relationship between the manifestation of the symptom complex and negative pressure; 5) electrocardigrams were taken for 20 of the healthy patients, none of whom showed a quickened heart rate during or after the procedure; and 6) treatment for the symptom complex was by acupuncture or by injection of Atropine. The 32 acupuncture patients suffered only backaches and lower abdominal swelling, but relief of pain was slow. 105 patients were administered Atropine, none of whom manifested the symptom complex. Only 19 women perspired slightly and felt chilled in the limbs, while 3 were nauseous. Of the 33 symptom complex patients, 5 had Atropine, most of whose heart rates returned to normal after 2 seconds to 2 minutes, as did their dizziness, perspiration, and ashen coloring. However, it was found that if no treatment was given after the symptom complex emerged, a majority of the patients returned to normal on their own, some taking as long as an hour. It is believed the occurrence of the symptom complex is directly related to the mechanical stimulus applied to the uterus or cervix, the vigorous shrinkage of the uterus, loss of blood, and the negative pressure suction power of the uterine wall. Further a mechanical stimulus to the uterus can cause an "errant" nervous reflex that will affect the heart rate. This errant nervous reflex can be cut off by an injection of Atropine.
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PMID:[A symptom-complex during artificial abortion (author's transl)]. 26 29

Intraesophageal balloon distension has been introduced recently as a provocative test in the assessment of patients with noncardiac chest pain. In order to examine the effect of balloon location and muscarinic blockade on distension-induced pain, 10 asymptomatic male volunteers were studied on two separate days using a low-compliance perfused manometry system that incorporated a silicone rubber balloon. Five-second-duration balloon distensions using balloon volumes of 2.5, 5, 7.5, and 10 ml of air were performed with the balloon located both 16 cm (proximal site) and 6 cm (distal site) above the lower esophageal sphincter (LES) before and after administration of atropine (10 micrograms/kg intravenously) or placebo in a randomized double-blind fashion. A standardized scoring system was used to assess the balloon distension-induced pain. Pain scores varied directly with balloon volume but were consistently higher with the balloon located at the proximal site versus the distal site. This was not associated with any differences in intraballoon pressures between the two sites; however, contraction amplitude orad to the balloon was greater with balloon distension at the proximal site. Atropine significantly decreased pain sensation scores with the balloon located distally but not proximally. This attenuation was not associated with significant changes in intraballoon pressures; however, contractions orad to the balloon were markedly inhibited by atropine with distal but not with proximal distension. These studies indicate that balloon distension-induced pain varies depending on the location of distension. This difference is not explained by differences in esophageal wall tension at the site of distension.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Effect of intraesophageal location and muscarinic blockade on balloon distension-induced chest pain. 199 62

Syncope is a rare presentation of glossopharyngeal neuralgia (GN). The mechanisms of the syncope were studied in a patient with recurrent episodes comprising prolonged cardiac standstill and arterial hypotension. During attacks, no supraventricular or ventricular potentials were recorded in the ECG. Atropine prevented the cardiac arrest without affecting the pain, indicating the vagus as the efferent limb of the reflex asystole. Following atropine blood pressure continued to fall during GN attacks, suggesting abolition of sympathetic tone. Indeed, serum norepinephrine levels fell during these attacks. Infiltration of either vagus above the clavicle with local anesthetics did not abolish the cardiac asystole. Carbamazepine and a dual chamber pacemaker were effective in controlling the symptoms of the patient. The results suggest that, during a neuralgic attack, the stimulation excites both vagi, causing asystole and simultaneously abolishes sympathetic tone.
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PMID:Mechanisms of syncope in glossopharyngeal neuralgia. 241 79

The authors analyzed retrospectively the course of acute myocardial infarction in 165 patients, who needed temporary pacing. Medicamentous influencing with Atropine was not very effective and isoprenaline influencing with atropine was not very effective and isoprenaline was used only to brigade the time before the electrode was introduced. From the whole group, 36 patients were selected who had been admitted to the coronary unit within 4 hours after the development of pain. The authors investigated the development and regression of impaired conduction and investigated whether early admission, early diagnosis of bradyarrhythmia and early introduction of temporary pacing affect the patients' prognosis. In the group of patients admitted within 4 hours pacing was needed on admission by 25% of the patients and in the group admitted later by 75.9%. In the majority of early admissions the authors investigated the development of disorders in the course of the first 24 hours. Early admission did not affect the mortality which is high and differs by the site of the infarction. In infarctions of the lower wall 27.3% of the early admissions died and 32.1% of those admitted after the 4th hour. In infarctions of the anterior wall in the group admitted within four hours 57.1% died and in the group admitted after 4 hours 67.3%. The high mortality is associated with the site but in particular with the extent of the necrotic focus.
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PMID:[The effect of temporary cardiac stimulation on the course of acute myocardial infarct]. 261 82

The effects of various sedatives on air cystometry in dogs were investigated. Oxymorphone plus acepromazine, xylazine alone, atropine plus xylazine, and diazepam plus ketamine were compared for interference with the detrusor reflex, adequacy of patient restraint, and development of adverse side effects. Atropine plus xylazine was the best of the 4 drug combinations tested, because it had the least interference with the detrusor reflex, bradycardia did not develop, and excellent restraint was obtained. Pain and hematuria were common whenever intravesicular pressure exceeded 40 cm of H2O, yet pressures that high were rarely necessary to stimulate the detrusor reflex.
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PMID:Effects of various sedatives on air cystometry in dogs. 322 60

It has been debated whether or not decapitation of conscious animals is a humane procedure. This problem may be clarified on the basis of recent research that has indicated that neocortical low voltage fast activity (LVFA) and hippocampal rhythmical slow activity (RSA) can result from activity in either the cholinergic corticipetal projections from the basal forebrain or the serotonergic corticipetal projections from the brainstem. These inputs appear to produce, respectively, atropine-sensitive LVFA and RSA and atropine-resistant LVFA and RSA. In waking animals, atropine-resistant LVFA and RSA occur only in close correlation with motor activities such as spontaneous changes in posture, walking or struggling (Type 1 behavior). Painful stimuli readily elicit both Type 1 behavior and LVFA and RSA in atropine-treated rats. Atropine-sensitive LVFA and RSA may occur in anesthetized as well as in conscious animals, but atropine-resistant LVFA and RSA are generally absent during anesthesia. In the experiments reported here, rats were decapitated: (1) in the normal waking state; (2) after pretreatment with atropine or scopolamine; or (3) following induction of anesthesia with ethyl ether. Clear hippocampal RSA and neocortical LVFA were observed in conditions 1 and 3 but not in condition 2. It is concluded: (A) that atropine-sensitive LVFA and RSA are not good indices of conscious perception of pain since these waveforms occur during anesthesia as well as in the waking state; and (B) that the cerebral reaction to decapitation does not resemble the usual cerebral reaction to painful stimuli. This is consistent with the view that decapitation is not inhumane.
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PMID:Neocortical and hippocampal electrical activity following decapitation in the rat. 325 94

A 70-year-old man presented with diffuse triple-vessel coronary arterial spasm accompanied by ST segment elevation in the inferior and anterior leads when the severity of pain moderated. At the beginning, he noted throat and chest pain followed by syncope. Atropine, norepinephrine, and lidocaine were administered therapeutically. The initial electrocardiogram showed an idioventricular rhythm without ST segment deviations, which made the prompt diagnosis of coronary arterial spasm difficult.
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PMID:Diffuse triple-vessel coronary artery spasm complicated by idioventricular rhythm and syncope. 359 34

General pharmacological properties of 4'-fluoro-4-[4-(2-thioxo-1-benzimidazolinyl) piperidino] butyrophenone (timiperone), a new neuroleptic drug, were compared with those of haloperidol. 1. Central nervous system: In behavioral observation, timiperone showed a typical neuroleptic profile at doses of 0.1 mg/kg p.o. and more (mice). The drug produced a moderate hypothermia at 10 mg/kg p.o. (rabbits), a mild increase in pain threshold at 3 mg/kg p.o. (mice and rats) and a slowing of cortical EEG at 1 mg/kg i.v. (cats). ED50 values of drug for the potentiation of ether and alcohol anesthesia were 0.34 and 0.22 mg/kg p.o., respectively (mice). Timiperone ahd neither an anticonvulsant activity at 30 mg/kg p.o. (mice) nor an effect on the spinal reflex at 1 mg/kg i.v. (cats). These effects of timiperone on the central nervous system were almost similar to those of haloperidol. 2. Respiratory and cardiovascular system: At dose of 0.03 mg/kg i.v. and more, timiperone produced transient increases in respiratory rate and regional arterial blood flow which were accompanied by a fall in blood pressure (dogs). Haloperidol had qualitatively similar effect, but was weaker than timiperone. Both drugs at high concentration (3X10-6 g/ml) exerted negative inotropic and chronotropic effect in isolated atrial preparations (guinea-pigs), and non-competitively antagonized the positive chronotropic action of isoprenaline. Atropine (2.5X10-7 g/ml) failed to modify the chronotropic action of timiperone (3X10-6 g/ml). 3. Autonomic nervous system: Timiperone at 0.1 mg/kg p.o. and haloperidol at 0.3 mg/kg p.o. induced a moderate miosis (rabbits) and antagonized blood responses to noradrenaline and acetylcholine (dogs). Both drugs at 1 mg/kg i.v. had no ganglion-blocking activity (cats). 4. Smooth muscle: In isolated guinea-pig ileum and vas deferens, timiperone and haloperidol (10-5 g/ml) antagonized the contractile responses of the muscles to various spasmogens, Both drugs at approximately 10-6 g/ml decreased spontaneous motility of the isolated rat uterus and inhibited the gastric secretion at 1 mg/kg i.p. (rats). At high doses, both drugs inhibited the gastrointestinal propulsion (mice), motility (dogs) and gastric emptying rate (rats), and had no damaging effect on the gastric mucosa (rats). 5. Skeletal muscle: At 0.1 mg/kg i.v., timiperone and haloperidol slightly enhanced twitch response of the anterior tibial muscle to electrical stimulation (rabbits). 6. Urine volume and urinary electrolytes: Timiperone and haloperidol showed a diuretic effect at 3 mg/kg p.o. whereas they inhibited urine output and electrolytes excretion at 30 mg/kg p.o. (rats).
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PMID:Pharmacological studies on timiperone, a new neuroleptic drug Part II: General pharmacological properties. 611 34

Interaction of tropane derivatives (motropin, atropine, cocaine) with opiates (morphine) and opioids (an enkephalin amide analog) was studied according to varying tests: pain sensitivity, impulse summation in the central nervous system, respiration. It appeared that motropin is a morphine antagonist and enkephalin amide analog from the standpoint of effect on analgetic action and impulse summation, but is not their antagonist as regards the effect on respiration. Atropine is a weak morphine antagonist in terms of the effect on analgesia, impulse summation and respiration as well. Cocaine is a morphine synergist as regards all the tests indicated. Therefore, the effect of tropane derivatives on pain sensitivity, impulse summation and respiration is mediated via different opiate receptors, which does not exclude the involvement of other neurochemical mechanisms in their action.
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PMID:[Tropane ligands of different types of opiate receptors]. 629 64


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