Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Previous studies in animals suggested that a coadministration of the anti-rheumatic/anti-inflammatory agent tolmetin (Tolectin) and of paracetamol potentiates the effects of these two drugs. The present study was carried out to assess whether or not the dosis of tolmetin necessary to obtain an analgesic effect can be reduced when paracetamol is coadministered in a model with experimentally induced pain in healthy human subjects. The effects of tolmetin 200 mg (T 200), paracetamol 400 mg (P 400), tolmetin 150 mg plus paracetamol 300 mg (T 150 + P 300), and of tolmetin 100 mg plus paracetamol 400 mg (T 100 + P 400) on pain threshold to electrical and thermal stimuli and on pain tolerance to electrical stimuli were compared to the effects of placebo under double blind conditions. Each of 20 healthy volunteers received all of the 5 treatments randomised according to four 5 X 5 Latin squares. The results showed that the combination T 100 + P 400 had better analgesic effects than the double dose of tolmetin, T 200, alone, while the effects of P 400 could not be discrminated from placebo. In a sequential t-test the effects of T 100 + P 400 could be discriminated from placebo already after 14 Ss. The effects of T 200, T 150 + P 300, and T 100 + P 400 respectively could not be differentiated, indicating that the dose of tolmetin can be reduced markedly by simultaneous administration of paracetamol without a loss in analgesic potency. Coadministration of tolmetin and paracetamol permits a marked reduction of the dose of tolmetin without any loss of analgesic potency as measured in a model with experimentally induced pain in healthy subjects.
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PMID:Effects of tolmetin, paracetamol, and of two combinations of tolmetin and paracetamol as compared to placebo on experimentally induced pain. A double blind study. 38 Dec 21

The effectiveness and tolerability of Tolectin Gel 5% was evaluated in an open, multicentric study. 205 patients suffering from osteoarthrosis, spondylarthrosis, soft tissue rheumatism and post-traumatic pain were treated under conditions similar to practice. The topical preparation was administrated alone or when needed associated with Tolectin 400 mg/Capsules. Evaluation of symptoms and signs revealed no statistical difference of effectiveness between the two dosage groups. The topical preparation can be considered as effective as demonstrated by evolution of the assessed parameters under treatment. This positive result is confirmed by the opinion of the doctors and patients about the clinical evolution. The general assessment of the therapeutical efficacy and of the tolerance was confirmed by both observers. Strikingly these datas refers the osteoarthrosis and spondylarthroses patients as to those suffering from soft tissue rheumatism and posttraumatic pain. A dosis reduction of the oral other parenteral preparations is frequently possible by means of a concomitant topical treatment. In some types of soft tissue and articular rheumatism, chiefly in light cases, the local application alone can be sufficient. Tolectin Gel 5% constitutes a new possibility of therapy with local, efficient antirheumatic preparations.
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PMID:[Clinical experiences with 5% Tolectin (tolmetin) gel in patients with degenerative joint and spine diseases and soft tissue rheumatism]. 660 79