Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Radiotherapy may be associated with both permanent and transient neurological adverse effects. We report seven cases of previously undocumented type of transient hyperesthesia and radicular pain occurring after radiotherapy for thoracic malignancies and describe the potential mechanisms. This is different to Lhermitte's sign in its character, location, and duration of symptoms. Knowledge of such adverse effects will prevent inappropriate investigations and anxiety for patients.
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PMID:Transient hyperesthesia and radicular pain: an unrecognised complication of thoracic radiotherapy. 2578 34

A 64-year-old Japanese man with no significant medical history presented with epigastric discomfort of 2-weeks' duration. He was diagnosed with metastatic HER2-positive gastric cancer. Chemotherapy with capecitabine, oxaliplatin, and trastuzumab was initiated. During the eighth cycle, he suddenly complained of electric shock-like pain in both legs upon neck flexion, consistent with Lhermitte's sign. Oxaliplatin was discontinued, and Lhermitte's sign resolved after 3 months. Neurotoxicity is commonly observed in platinum-based chemotherapy, but Lhermitte's sign is rare. This is the first report of oxaliplatin-induced Lhermitte's sign in a gastric cancer patient.
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PMID:Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer. 3267 Jun 52


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