Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was performed on 187 patients with vibration syndrome treated and followed for more than five years in 10 hospitals in Japan. The subjects had disturbances of circulation and sensation in their fingers and of joint movements in their upper extremities. Most of the patients received treatment combining physical and drug therapy. Data were analyzed to determine the effective treatment period for improving the disturbances. The blanching attack Raynaud's phenomenon) and abnormal cold and tingling sensations in the fingers were significantly improved only during the first two years of treatment. A temperature test and plethysmography suggested improvement in finger circulation only during the first three years and one year of treatment, respectively. Spontaneous numbness and pain in the fingers did not improve. The pin-prick and vibratory sensations showed recovery only during the first three and two years of treatment, respectively. Lowered conduction velocities of the ulnar and median nerves improved only during the first year. Limited movements in the wrist and elbow joints did not improve at all despite long-term treatment. Similar results were seen in an overall evaluation of the data. It was concluded that there is a limitation in the treatment of disturbances related to the vibration syndrome.
 ...
PMID:Follow-up study of patients with vibration syndrome in Japan. 377 15

The purpose of this study was to define as a distinct clinical entity the syndrome of neurapraxia of the cervical spinal cord with transient quadriplegia. The sensory changes include burning pain, numbness, tingling, and loss of sensation, while the motor changes range from weakness to complete paralysis. The episodes are transient and complete recovery usually occurs in ten to fifteen minutes, although in some patients gradual resolution occurs over a period of thirty-six to forty-eight hours. Except for burning paresthesia, pain in the neck is not present at the time of injury and there is complete return of motor function and full, pain-free motion of the cervical spine. In our series, routine roentgenograms of the cervical spine were negative for fractures or dislocations in all patients. However, the roentgenographic findings did include developmental spinal stenosis in seventeen patients, congenital fusion in five patients, cervical instability in four patients, and intervertebral disc disease in six patients. Spinal stenosis was determined by two different roentgenographic methods. The first was the standard method, and the second was a ratio method devised by us. Both measurements were made at the level of the third through the sixth vertebral body on a routine lateral roentgenogram of the cervical spine that was available for twenty-four of the thirty-two patients and for a control group of forty-nine male subjects of similar age who did not have any neurological complaints. Using the ratio method, a measurement of less than 0.80 indicated significant spinal stenosis in the group of twenty-four patients for whom roentgenograms were available, as compared with a ratio of approximately 1.00 or more in the control group. There was statistically significant spinal stenosis (p less than 0.0001) in all of the patients as compared with the control subjects by both methods of determining spinal stenosis. A survey of 503 schools participating in National Collegiate Athletic Association (NCAA) football in the 1984 season found that 1.3 per 10,000 athletes had a history that was suggestive of neurapraxia of the cervical spinal cord. The phenomenon of neurapraxia of the cervical spinal cord occurs in individuals with developmental stenosis of the cervical spine, congenital fusion, cervical instability, or protrusion of an intervertebral disc in association with a decrease in the anteroposterior diameter of the spinal canal. We postulate that in athletes with diminution of the anteroposterior diameter of the spinal canal the spinal cord can, on forced hyperextension or hyperflexion, be compressed, causing transitory motor and sensory manifestations.(ABSTRACT TRUNCATED AT 400 WORDS)
 ...
PMID:Neurapraxia of the cervical spinal cord with transient quadriplegia. 378 7

Six cases with secondary syringomyelia were evaluated clinically and the pathogenesis was discussed. Three cases had the tumors; an ependymoma arising from the conus medullaris and the filum terminale, a foramen magnum meningioma extending to C2 and a thoracic astrocytoma. Two cases had past history of spinal cord injury with L1 and L2 fracture-dislocation, respectively. One case showed hydromyelic symptoms associated with isolated fourth ventricle after post-meningitic hydrocephalus. Clinical symptoms and signs were complex and various in each case due to the association of the original disease and the syrinx. Syringomyelic symptoms were dominant in three cases of which the syrinx extended from the conus to the cervical cord. Initial symptoms of two cases with post-traumatic syringomyelia were tingling pains which began near the site of injury and extended rostrally. Metrizamide myelography revealed complete or incomplete block at the location of the tumors or the injuries. Delayed CT demonstrated the syrinx in all cases. The syrinx was always present near the sites of primary lesions. The communication between the syrinx and the fourth ventricle was suspected in three cases, and the communication of the syrinx and the spinal subarachnoid space was suspected in two cases. All cases underwent the surgical treatments. Total removal of the tumors were completed in two cases and relieved the majority of symptoms. On the other hand, a case with a thoracic astrocytoma underwent biopsy of the tumor and irradiation, followed by poor outcome. Syringo-peritoneal shunts were performed in two cases with post-traumatic syringomyelia and relieved pain, but neurological signs were unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Pathogenesis and the treatment of secondary syringomyelia]. 382 49

Motor and sensory responses induced by trial stimulation were examined before stereotaxically implanting a permanent stimulating electrode for pain relief in 11 patients with intractable pain of central origin. The total number of points eliciting a response when stimulated was 70. The points of stimulation were determined as exactly as possible from Schaltenbrand and Bailey's Atlas. Motor responses were detected upon stimulating 21 points, the majority of which were in the posterior third of the posterior limb of the internal capsule (IC). Stimulation of these 21 points was accompanied by pain relief in only two points (10%). Warm (22) or cool sensations (three) were provoked in the most posteromedial portion of the posterior limb of the IC, nucleus reticularis pulvinaris, and area triangularis, and seven (28%) of these 25 sensations were accompanied by pain relief. A burning sensation was found upon stimulation of 12 points, with stimulation in the mesencephalic lateral tegmental field eliciting the most severe burning pain. A tingling sensation was elicited at 12 points, in a distribution similar to that of the warm sensation. Five (42%) of these 12 points provided pain relief. The best stimulating point for pain relief is not in the center of the posterior limb of the IC, directly lateral to the posterior commissure, but rather in its most posteromedial part; that is, at the nucleus reticularis pulvinaris or area triangularis.
 ...
PMID:Sensory and motor responses to deep brain stimulation. Correlation with anatomical structures. 389 95

Meralgia paresthetica is an uncommon entrapment neuropathy involving the lateral femoral cutaneous nerve of the thigh. Symptoms include numbness, tingling and pain in the anterolateral thigh. The condition can be differentiated from other neurologic disorders by the typical exacerbating factors and the characteristic distribution of involvement. The course tends to be one of lifelong flare-ups, but these can usually be successfully managed with a conservative approach.
 ...
PMID:Meralgia paresthetica. 395 39

A case is presented in which a mucous retention cyst that obliterated the right maxillary sinus caused symptoms due to pressure on two separate branches of the second branch of the fifth cranial nerve during a chamber dive to 112 feet. The symptoms of pain and numbness occurred at different times during and after the dive. Referred pain to the maxillary teeth was due to pressure on the posterior superior alveolar branch and paresthesia with numbness and tingling of the lip and cheek was caused from pressure on the infraorbital nerve prior to its emergence through the infraorbital foramen. The symptoms resolved promptly on recompression treatment. The underlying mechanisms for the production of sinus barotrauma and the causes of tooth and sinus pain are differentiated, and a differential diagnosis of maxillary sinus opacities is schematized.
 ...
PMID:Maxillary sinus barotrauma--case report and review. 403 36

The anatomy of the carpal tunnel was studied by postmortem dissection of both wrists in ten adults with normal wrists. Preoperative clinical and EMG examinations were performed on 28 wrists in 23 patients suffering from carpal tunnel syndrome. Anatomical and histological studies were made in connection with operation, and postoperatively the condition was followed clinically and by EMG. Numbness, tingling, and pain of the hands were markedly relieved during 2 months of follow-up, whereas clumsiness and weakness showed no significant change. preoperatively, EMG showed sensory abnormalities in 96% of cases and motoric abnormalities in 82%. The diagnostic accuracy of EMG was good, in particular as regards the sensory aspect. The return to normal of EMg was slow. Pathoanatomical examination showed a normal tendon sheath and transverse carpal ligament in 52%, while rheuma was found in the specimens of 12%, fibrosis of the tendon sheath in 36%, and fibrosis of the transverse carpal ligament in 32%. No correlation was observed between the shape of the osseous carpal tunnel and the degree of clinical symptoms.
 ...
PMID:Carpal tunnel syndrome. Anatomical and clinical investigation. 405 99

This report describes an entrapment syndrome of the superficial peroneal nerve terminal sensory branches. Two patients presented with numbness and tingling of the foot dorsum. These symptoms increased with activity such as walking, running, and squatting. The signs were 1) a decrease in sensation to light touch and pin prick on the foot dorsum over the cutaneous distribution of the nerve with sparing of the first web space; 2) a soft tissue bulge over the anterolateral aspect of the leg approximately 10 cm above the lateral malleolus; 3) a Tinel sign over the bulge; 4) an increase in the size of the bulge either with resisted ankle dorsiflexion or weight bearing; and 5) tenderness over the bulge or distally over the terminal sensory branches of the superficial peroneal nerve. Electrodiagnostic studies revealed an unrecordable evoked response or a prolonged distal latency of the terminal sensory branches of the superficial peroneal nerve. Treatment consisted of surgical decompression of the nerve at the bulge by fasciotomy. Patients responded with complete symptomatic relief. To provide accurate treatment, the diagnosis of entrapment syndrome of the superficial peroneal nerve terminal sensory branches must be differentiated from other causes of pain and numbness in the ankle area.
 ...
PMID:Terminal sensory branches of the superficial peroneal nerve: an entrapment syndrome. 406 33

The carpal tunnel syndrome, or compression neuropathy of the median nerve at the wrist, is a common cause of burning pain, numbness and tingling in the hand. The diagnosis is suggested by nocturnal paresthesias in the thumb, index and long fingers associated with signs of irritability of the median nerve in the carpal tunnel at the wrist. Surgical treatment in the form of incision of the transverse carpal ligament should be performed before irreversible motor and sensory changes occur.
 ...
PMID:The carpal tunnel syndrome. A review of 100 patients treated surgically. 565 44

In eight patients with intense chronic cutaneous pain, sensory nerves or roots. supplying the painful area were stimulated. Square-wave 0.1-millisecond pulses at 100 cycles per second were applied, and the voltage was raised until the patient reported tingling in the area. During this stimulation, pressure on previously sensitive areas failed to evoke pain. Four patients, who had diseases of their peripheral nerves, experienced relief of their pain for more than half an hour after stimulation for 2 minutes.
 ...
PMID:Temporary abolition of pain in man. 601 61


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>