Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030193 (pain)
 261,466 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Of 122 Geomedic arthroplasties performed, 85 were possible to follow up. The mean observation period was 58 months. The original position of the prosthesis was analyzed with respect to its effect on the clinical condition. A score system was used for this purpose. A normal alignment was obtained in 51%. No statistically significant correlation could be shown between a high radiographic score and a high clinical score. A resorption zone of 2mm or more, considered a sign of loosening, arose in 37% and a coexisting change of position in 12%. There is no difference in radiographic score between the prostheses which were judged as loose and the other prostheses. Twelve percent of the patients were reoperated because of loosening. The patients consider their condition to be very good or good in 93% of cases. Pain at rest and pain on weight bearing were totally absent in 87% and 72% of cases respectively.
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PMID:Long-term follow-up of patients with geomedic prostheses. 381 49

The results of excision of the distal ulna in 34 wrists of 25 patients with chronic rheumatoid arthritis of the distal radio-ulnar joint were reviewed. Rest pain had been cured or relieved in 77%, pain on pronation-supination in 86%, and limitation of pronation-supination in 90%, while 88% of the patients graded the result as excellent or fair. Despite this marked relief of symptoms, function of the upper limb was improved in only 25% of patients and remained unchanged in 60%. Ulnar subluxation of the carpus had occurred in 24% but seemed to be related to the destructive disease process rather than to the operation itself. The length of ulna resected was not related to the outcome of the operation.
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PMID:Excision of the distal ulna in patients with rheumatoid arthritis. 381 49

Pedicled omentum, after lengthening, was transferred to the ischemic lower limbs of 12 patients with Buerger's disease to assess its capacity to improve the blood supply to these compromised extremities. The immediate (after one month) and long-term (9-12 months) results were encouraging. After one month, rest pain had diminished in 83% of cases, claudication was relieved in 75% of cases, temperature became normal in all cases (100%) and ischemic ulcers either healed or showed signs of healing in 83% of cases. During long-term follow up (after 9-12 months), the results deteriorated slightly, but they remained promising. Rest pain had disappeared in 80% of cases. Claudication was still relieved in 70% of cases, temperature was still improved in 60% and ulcers had healed completely in 67% of cases.
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PMID:Pedicled omental grafts in the revascularization of ischemic lower limbs in Buerger's disease. 383 69

In the elderly, arterial disease may not necessarily require operative intervention if the patient is not functionally disabled or can adjust to self-imposed limitations. However, with nonhealing skin lesions, gangrene, impending limb loss, or ischemic rest pain, reconstructive arterial surgery must be considered. Pain at rest signals advanced limb-threatening ischemia. The pattern of pain distribution over the foot distinguishes it from common nighttime leg cramps.
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PMID:Peripheral vascular disease: treatment and referral of the elderly. Part I. 388 86

The results of a randomized, controlled, prospective double-blind trial of phenol chemical sympathectomy against placebo bupivacaine injection in 41 limbs (24 treatment and 17 control) have been presented. Ablation of the skin potential response was used as an indication of successful sympathectomy. Rest pain was relieved in 83.5 percent of patients at 1 week with a placebo response of 23.5 percent (chi-square test, p less than 0.002). Sixty-six percent of patients remained free from rest pain at 6 months (chi-square test, p less than 0.02). The ankle-brachial systolic pressure index and resting and peak (reactive hyperemic) blood flows were measured in the foot; there was no demonstrable improvement in these hemodynamic factors. Chemical sympathectomy in these circumstances is probably acting as a pain-relieving injection but nevertheless produces useful remission of rest pain in these inoperable but otherwise relatively stable patients. It can also be employed while relevant investigations are carried out before direct arterial surgery.
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PMID:Chemical lumbar sympathectomy for ischemic rest pain. A randomized, prospective controlled clinical trial. 389 91

Pain at rest with osteoarthritis of the hip may be due to increased intraosseous blood pressure, which falls immediately after an intertrochanteric osteotomy. Eighty-five consecutive hips from patients under 60 years of age at the time of operation were studied in order to evaluate if pain at rest was an indication for intertrochanteric osteotomy. Patients who operatively were predominantly in pain at rest had a significantly better prognosis than patients with a predominantly weight-bearing pain (P less than 0.05). Intertrochanteric osteotomy reduced pain for the group of patients with predominant pain at rest (n = 50) by 81%, 66%, and 56% at 5, 10, and 15 years respectively. In the group where weight-bearing pain was predominant (n = 35), the operation was a success in only 39% at 5 years and after.
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PMID:Osteoarthritis of the hip in patients under 60 years of age. A study of the importance of pain at rest as an indication for intertrochanteric osteotomy. 409 31

Eight patients with ischemic lower extremity ulcers were entered into a randomized, controlled trial of intravenous prostaglandin E1 (PGE1) versus placebo. All ulcers had been stable or increasing in size for at least 3 weeks prior to the study. Each patient had rest pain assessment, Doppler pressure measurements, and ulcer measurements before and after infusion. Four patients received PGE1 and four received placebo. There were no significant preinfusion differences between groups. Rest pain remained stable or improved in all patients. In the placebo group the mean absolute ankle pressure decreased 5 +/- 14 mm Hg, but the mean ankle/arm pressure ratio increased 0.03 +/- 0.06. In the PGE1 group the mean absolute ankle pressure decreased 16 +/- 16 mm Hg and the mean ankle/arm pressure ratio decreased 0.05 +/- 0.06. Neither difference is statistically significant. Patients who received placebo had no change or decrease in ulcer size, but all patients who received PGE1 had an increase in ulcer size (P = 0.05, Wilcoxon rank sum test). One of the four placebo patients required extremity amputation during follow-up of 10.5 +/- 3.5 months. All four patients in the PGE1 group required amputation within 3.3 +/- 2.6 months. Despite theoretic benefits, intravenous PGE1 may be detrimental in the treatment of ischemic ulcers.
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PMID:Detrimental effect of high-dose prostaglandin E1 in the treatment of ischemic ulcers. 634 95

A parallel, double-blind, placebo controlled and randomized study in a single center was done with ketoprofen 2.5% gel to treat acute soft tissue injuries. Patients applied the gel twice a day for seven days, corresponding to 250 mg of ketoprofen per day. Assessments were made on the third and seventh day by VAS, subjective evaluation and pain threshold algometry. The study group consisted of 29 patients and the control group 27 patients. Pain at rest was significantly relieved in the ketoprofen group, whereas in the placebo group the difference was not significant. In terms of side-effects, no difference between the groups was noticed. In both groups, local dermal irritation was found. Our results suggested that ketoprofen 2.5% gel was safe and superior to placebo in the treatment of soft tissue injuries.
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PMID:Ketoprofen 2.5% gel versus placebo gel in the treatment of acute soft tissue injuries. 829 70

100 thumbs with primary osteoarthrosis of the joints of the trapezium were treated by trapeziectomy and a FCR sling arthroplasty to reconstruct a first intermetacarpal ligament by the method described by Burton and Pellegrini (1986). Pain at rest remained in five. Some pain at or after exertion persisted in 46, and 49 became completely pain-free. 88 were satisfied with the procedure and there was a significant increase in pinch strength and in the ability to perform activities of daily life. It has become our preferred procedure for treating osteoarthrosis of the basal joint of the thumb.
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PMID:Trapeziectomy and ligament reconstruction for osteoarthrosis of the base of the thumb. A prospective study of 100 operations. 829 27

The diagnosis of unstable angina encompasses a broad spectrum of patients with myocardial ischemia, varying widely in cause, prognosis and responsiveness to therapy. A new clinical classification of unstable angina is based on the following 2 components: severity, and the clinical setting in which unstable angina develops. The hypothesis that this clinical classification correlates with the underlying coronary artery anatomy was tested. In 238 consecutive patients, an unstable angina score ranging from 2 to 6 was determined by adding the scores for severity (1 = unstable angina without pain at rest; 2 = pain at rest > 48 hours before angiography; and 3 = pain at rest < or = 48 hours before angiographic evaluation) and the clinical setting of unstable angina (1 = unstable angina secondary to a noncardiac condition; 2 = primary unstable angina; and 3 = early postinfarction unstable angina). Fifty concurrently studied consecutive patients with stable angina were assigned a score of 0. Patients with unstable angina averaged 63 +/- 11 years of age, and 165 were men (69%). Pain at rest occurred in 202 of 238 patients (85%), and angiography was performed < or = 48 hours in 139 of these patients (69%). Among patients with unstable angina, 5 (2%) had secondary unstable angina, 143 (60%) had primary unstable angina, and 90 (38%) had postinfarction unstable angina. Multivariable regression analysis identified the unstable angina score as the most important predictor of intracoronary thrombus (p = 0.011) and lesion complexity (p = 0.004) in the ischemia-related artery.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Relation between clinical presentation and angiographic findings in unstable angina pectoris, and comparison with that in stable angina. 836 68


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